Vaughan, Ashley, Chiu, Sum-Ying, Ramasamy, Gowthaman, Li, Ling, Gardner, Malcolm J., Tarun, Alice S., ...
Motivation: The sequencing of the Plasmodium yoelii genome, a model rodent malaria parasite, has greatly facilitated research for the development of new drug and vaccine candidates against malaria....
A family of chimeric erythrocyte binding proteins of malaria parasites
Kappe, Stefan H. I., Noe, Amy R., Fraser, Tresa S., Blair, Peter L., Adams, John H.
Proteins sequestered within organelles of the apical complex of malaria merozoites are involved in erythrocyte invasion, but few of these proteins and their interaction with the host erythrocyte have...
Exploring the transcriptome of the malaria sporozoite stage
Kappe, Stefan H. I., Gardner, Malcolm J., Brown, Stuart M., Ross, Jessica, Matuschewski, Kai, Ribeiro, Jose M., ...
Most studies of gene expression in Plasmodium have been concerned with asexual and/or sexual erythrocytic stages. Identification and cloning of genes expressed in the preerythrocytic stages lag far...
A family of chimeric erythrocyte binding proteins of malaria parasites
Kappe, Stefan H. I., Noe, Amy R., Fraser, Tresa S., Blair, Peter L., Adams, John H.
Proteins sequestered within organelles of the apical complex of malaria merozoites are involved in erythrocyte invasion, but few of these proteins and their interaction with the host erythrocyte have...
Exploring the transcriptome of the malaria sporozoite stage
Kappe, Stefan H. I., Gardner, Malcolm J., Brown, Stuart M., Ross, Jessica, Matuschewski, Kai, Ribeiro, Jose M., ...
Most studies of gene expression in Plasmodium have been concerned with asexual and/or sexual erythrocytic stages. Identification and cloning of genes expressed in the preerythrocytic stages lag far...
Plasmodium liver stage developmental arrest by depletion of a protein at the parasite–host interface
Mueller, Ann-Kristin, Camargo, Nelly, Kaiser, Karine, Andorfer, Cathy, Frevert, Ute, Matuschewski, Kai, ...
Plasmodium parasites of mammals, including the species that cause malaria in humans, infect the liver first and develop there into clinically silent liver stages. Liver stages grow and ultimately...
Release of Hepatic Plasmodium yoelii Merozoites into the Pulmonary Microvasculature
Baer, Kerstin, Klotz, Christian, Kappe, Stefan H. I, Schnieder, Thomas, Frevert, Ute
Plasmodium undergoes one round of multiplication in the liver prior to invading erythrocytes and initiating the symptomatic blood phase of the malaria infection. Productive hepatocyte infection by...
Labaied, Mehdi, Harupa, Anke, Dumpit, Ronald F., Coppens, Isabelle, Mikolajczak, Sebastian A., Kappe, Stefan H. I.
Malaria infection starts when sporozoites are transmitted to the mammalian host during a mosquito bite. Sporozoites enter the blood circulation, reach the liver, and infect hepatocytes. The formation...
Malaria: progress, perils, and prospects for eradication
Greenwood, Brian M., Fidock, David A., Kyle, Dennis E., Kappe, Stefan H.I., Alonso, Pedro L., Collins, Frank H., ...
There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by...
Kaiser, Karine, Camargo, Nelly, Kappe, Stefan H.I.
Malaria parasite species that infect mammals, including humans, must first take up residence in hepatic host cells as exoerythrocytic forms (EEF) before initiating infection of red blood cells that...
A combined transcriptome and proteome survey of malaria parasite liver stages
Tarun, Alice S., Peng, Xinxia, Dumpit, Ronald F., Ogata, Yuko, Silva-Rivera, Hilda, Camargo, Nelly, ...
For 50 years since their discovery, the malaria parasite liver stages (LS) have been difficult to analyze, impeding their utilization as a critical target for antiinfection vaccines and drugs. We...
Aly, Ahmed S I, Mikolajczak, Sebastian A, Rivera, Hilda Silva, Camargo, Nelly, Jacobs-Lorena, Vanessa, Labaied, Mehdi, ...
Malaria parasite sporozoites prepare for transmission to a mammalian host by upregulation of UIS (Upregulated in Infectious Sporozoites) genes. A number of UIS gene products are essential for the...
Kumar, Kota Arun, Baxter, Peter, Tarun, Alice S., Kappe, Stefan H. I., Nussenzweig, Victor
Immunization with radiation attenuated Plasmodium sporozoites (RAS) elicits sterile protective immunity against sporozoite challenge in murine models and in humans. Similarly to RAS, the genetically...
Mikolajczak, Sebastian A., Silva-Rivera, Hilda, Peng, Xinxia, Tarun, Alice S., Camargo, Nelly, Jacobs-Lorena, Vanessa, ...
The malaria parasite sporozoite transmission stage develops and differentiates within parasite oocysts on the Anopheles mosquito midgut. Successful inoculation of the parasite into a mammalian host...
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development
Vaughan, Ashley M, O'Neill, Matthew T, Tarun, Alice S, Camargo, Nelly, Phuong, Thuan M, Aly, Ahmed S I, ...
Intracellular malaria parasites require lipids for growth and replication. They possess a prokaryotic type II fatty acid synthesis (FAS II) pathway that localizes to the apicoplast plastid organelle...
Vaughan, Ashley, Chiu, Sum-Ying, Ramasamy, Gowthaman, Li, Ling, Gardner, Malcolm J., Tarun, Alice S., ...
Motivation: The sequencing of the Plasmodium yoelii genome, a model rodent malaria parasite, has greatly facilitated research for the development of new drug and vaccine candidates against malaria....
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design
VanBuskirk, Kelley M., O'Neill, Matthew T., De La Vega, Patricia, Maier, Alexander G., Krzych, Urszula, Williams, Jack, ...
Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium sporozoite stage during a blood meal. Irradiated sporozoites confer sterile protection against subsequent malaria...