Stefan Wagenpfeil

Multiple Testing for SNP-SNP Interactions (2007)

Boulesteix, Anne-Laure, Strobl, Carolin, Weidinger, Stefan, Wichmann, H.-Erich, Wagenpfeil, Stefan

Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...

Multiple Testing for SNP-SNP Interactions (2007)

Boulesteix, Anne-Laure, Strobl, Carolin, Weidinger, Stefan, Wichmann, H.-Erich, Wagenpfeil, Stefan

Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...

Multiple Testing for SNP-SNP Interactions (2007)

Boulesteix, Anne-Laure, Strobl, Carolin, Weidinger, Stefan, Wichmann, H.-Erich, Wagenpfeil, Stefan

Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...

Multiple Testing for SNP-SNP Interactions (2007)

Boulesteix, Anne-Laure, Strobl, Carolin, Weidinger, Stefan, Wichmann, H.-Erich, Wagenpfeil, Stefan

Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...

Summary (2007)

Stefan Wagenpfeil

Data-driven hyperparameter estimation or automatic choice of the smoothing parameter is of great importance, especially in the applications. This article presents and compares three methods for...

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease (2006)

Riemenschneider, Matthias, Konta, Lidija, Friedrich, Patricia, Schwarz, Sandra, Taddei, Kevin, Neff, Frauke, ...

A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21–q22. Within this region the plasminogen activator urokinase gene (PLAU) was...

Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues (2006)

Perneczky, Robert, Pohl, Corina, Sorg, Christian, Hartmann, Julia, Komossa, Katja, Alexopoulos, Panagiotis, ...

Background: the impact of cognitive impairment on activities of daily living (ADL) is being used as a major criterion for differentiating between mild cognitive impairment (MCI) and dementia. The...

Complex activities of daily living in mild cognitive impairment: conceptual and diagnostic issues (2006)

Perneczky, Robert, Pohl, Corina, Sorg, Christian, Hartmann, Julia, Komossa, Katja, Alexopoulos, Panagiotis, ...

Background: The impact of cognitive impairment on activities of daily living (ADL) is being used as a major criterion for differentiating between mild cognitive impairment (MCI) and dementia. The...

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease (2006)

Riemenschneider, Matthias, Konta, Lidija, Friedrich, Patricia, Schwarz, Sandra, Taddei, Kevin, Neff, Frauke, ...

A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21-q22. Within this region the plasminogen activator urokinase gene (PLAU) was...

Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo (2004)

Weber, Martin S., Starck, Michaela, Wagenpfeil, Stefan, Meinl, Edgar, Hohlfeld, Reinhard, Farina, Cinthia

It is widely assumed that glatiramer acetate (GA), an approved agent for the immunomodulatory treatment of multiple sclerosis, acts primarily as an antigen for T lymphocytes. Recent studies, however,...

Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo (2004)

Weber, Martin S., Starck, Michaela, Wagenpfeil, Stefan, Meinl, Edgar, Hohlfeld, Reinhard, Farina, Cinthia

It is widely assumed that glatiramer acetate (GA), an approved agent for the immunomodulatory treatment of multiple sclerosis, acts primarily as an antigen for T lymphocytes. Recent studies, however,...

Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo (2004)

Weber, Martin S., Starck, Michaela, Wagenpfeil, Stefan, Meinl, Edgar, Hohlfeld, Reinhard, Farina, Cinthia

It is widely assumed that glatiramer acetate (GA), an approved agent for the immunomodulatory treatment of multiple sclerosis, acts primarily as an antigen for T lymphocytes. Recent studies, however,...

Penalized Likelihood Estimation And Iterative Kalman Smoothing For Non-Gaussian Dynamic Regression Models (1997)

Ludwig Fahrmeir, Stefan Wagenpfeil

. Dynamic regression or state space models provide a flexible framework for analyzing non-Gaussian time series and longitudinal data, covering for example models for discrete longitudinal...

Estimating Time-Varying Effects of Prognostic Factors for Stomach Cancer Patients within a Dynamic Grouped Cox Model (1996)

Stark, M., Wagenpfeil, Stefan, Nekarda, H.

We describe the identification of prognostic factors in the framework of a completely resected stomach cancer survival-study. For the analysis the dynamic grouped Cox-Model was used allowing for...

Dynamische Modelle zur Ereignisanalyse (1996)

Wagenpfeil, Stefan

Im Rahmen dieser Dissertation werden zeitdiskrete Modelle zur Ereignisanalyse mit dynamischen Effekten vorgestellt, unterteilt nach Ein-Episoden-Ein- Zustands-, Ein-Episoden-Mehr-Zustands- und...

Smoothing Hazard Functions and Time-Varying Effects in Discrete Duration and Competing Risks Models (1996)

Ludwig Fahrmeir, Stefan Wagenpfeil

this paper we propose state space or dynamic models as a flexible technique, which makes simultaneous modelling and smooth estimation of hazard functions and covariate effects possible. The...

Penalized likelihood estimation and iterative kalman smoothing for non-gaussian dynamic regression models (1995)

Fahrmeir, Ludwig, Wagenpfeil, Stefan

Dynamic regression or state space models provide a flexible framework for analyzing non-Gaussian time series and longitudinal data, covering for example models for discrete longitudinal observations....

Hyperparameter Estimation in Exponential Family State Space Models (1995)

Wagenpfeil, Stefan

Data-driven hyperparameter estimation or automatic choice of the smoothing parameter is of great importance, especially in the applications. This article presents and compares three methods for...

Smoothing Hazard Functions and Time-Varying Effects in Discrete Duration and Competing Risks Models (1995)

Fahrmeir, Ludwig, Wagenpfeil, Stefan

State space or dynamic approaches to discrete or grouped duration data with competing risks or multiple terminating events allow simultaneous modelling and smooth estimation of hazard functions and...

Acupuncture in patients with tension-type headache: randomised controlled trial

Melchart, Dieter, Streng, Andrea, Hoppe, Andrea, Brinkhaus, Benno, Witt, Claudia, Wagenpfeil, Stefan, ...

Objective To investigate the effectiveness of acupuncture compared with minimal acupuncture and with no acupuncture in patients with tension-type headache.

Acupuncture in patients with tension-type headache: randomised controlled trial

Melchart, Dieter, Streng, Andrea, Hoppe, Andrea, Brinkhaus, Benno, Witt, Claudia, Wagenpfeil, Stefan, ...

Objective To investigate the effectiveness of acupuncture compared with minimal acupuncture and with no acupuncture in patients with tension-type headache.

Multiple Testing for SNP-SNP Interactions

Anne-Laure Boulesteix, Carolin Strobl, Stefan Weidinger, Stefan Wagenpfeil

Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction...

Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus

Weidinger, Stephan, Gieger, Christian, Rodriguez, Elke, Baurecht, Hansjörg, Mempel, Martin, Klopp, Norman, ...

High levels of serum IgE are considered markers of parasite and helminth exposure. In addition, they are associated with allergic disorders, play a key role in anti-tumoral defence, and are crucial...