T. Akiyama

Details der Publikationsliste

Zeitraum

1984 - 2009

Anzahl

131

Co-Autoren

Self-ignition combustion synthesis of TiFe in hydrogen atmosphere (2009)

Wakabayashi, R., Sasaki, S., Saita, I., Sato, M., Uesugi, H., Akiyama, T.

This paper describes the self-ignition combustion synthesis (SICS) of highly active titanium iron (TiFe) in a high-pressure hydrogen atmosphere without employing an activation process. In the...

Adaptive Importance Sampling with Automatic Model Selection in Value Function Approximation (2008)

Hachiya, H., Akiyama, T., Sugiyama, M., Peters, J., Fox, D., Gomes, C. P.

Off-policy reinforcement learning is aimed at efficiently reusing data samples gathered in the past, which is an essential problem for physically grounded AI as experiments are usually prohibitively...

Concept and demonstration of individual probe actuation in two-dimensional parallel atomic force microscope system (2007)

Akiyama, T., Aeschimann, L., Chantada, L., De Rooij, N. F., Heinzelmann, H., Herzig, H. P., ...

A concept of an array actuator that is used to control the tip-sample separation of cantilevers in a two-dimensional (2D) probe array scanning system is proposed in this article. The feasibility of...

Overview of confinement and MHD stability in the Large Helical Device (2005)

Motojima,O., Ida,K., Watanabe,K. Y., Nagayama,Y., Komori,A., Morisaki,T., ...

This article based on the 2004 Fusion Energy Conference contributions (Vilamoura, Portugal, 1-6 November 2004)

Review on the progress of the LHD experiment (2004)

Motojima, O., Yamada, H., Komori, A., Watanabe, K. Y., Mutoh, T., Takeiri, Y., ...

Recent progress in the Large Helical Device (LHD) experiment during the last 2 yr is reviewed. The LHD has been extending its operational regime toward fusion-relevant conditions while taking...

A demonstration of magnetic field optimization in LHD (2003)

Murakami,S., Yamada,H., Wakasa,A., Sasao,M., Isobe,M., Ozaki,T., ...

The behaviors of trapped particles in helical ripples are complicated and would enhance the radial transport of energetic particles and thermal plasma (neoclassical transport) in heliotrons. Thus the...

MHD instabilities and their effects on plasma confinement in the large helical device plasmas (2003)

Toi,K., Ohdachi,S., Yamamoto,S., Nakajima,N., Sakakibara,S., Watanabe,K. Y., ...

MHD stability of NBI heated plasmas and impacts of MHD modes on plasma confinement are intensively studied in the Large Helical Device (LHD). Three characteristic MHD instabilities were observed,...

A demonstration of magnetic field optimization in LHD (2003)

Murakami, S., Yamada, H., Wakasa, A., Sasao, M., Isobe, M., Ozaki, T., ...

The behaviors of trapped particles in helical ripples are complicated and would enhance the radial transport of energetic particles and thermal plasma (neoclassical transport) in heliotrons. Thus the...

MHD instabilities and their effects on plasma confinement in the large helical device plasmas (2003)

Toi, K., Ohdachi, S., Yamamoto, S., Nakajima, N., Sakakibara, S., Watanabe, K. Y., ...

MHD stability of NBI heated plasmas and impacts of MHD modes on plasma confinement are intensively studied in the Large Helical Device (LHD). Three characteristic MHD instabilities were observed,...

Impact of heat deposition profile on global confinement of NBI heated plasmas in the LHD (2003)

Yamada, H., Murakami, S., Yamazaki, K., Kaneko, O., Miyazawa, J., Sakamoto, R., ...

Energy confinement and heat transport of net-current-free NBI heated plasmas in the large helical device (LHD) are discussed with emphasis on density and power deposition profile dependences....

Recent advances in the LHD experiment (2003)

Motojima, O., Ohyabu, N., Komori, A., Kaneko, O., Yamada, H., Kawahata, K., ...

In the first four years of the LHD experiment, several encouraging results have emerged, the most significant of which is that MHD stability and good transport are compatible in the inward shifted...

Characterization of an integrated force sensor based on a MOS transistor for applications in scanning force microscopy (1998)

Akiyama, T, Tonin, A, Hidber, H R, Brugger, J, Vettiger, P, Staufer, U, ...

In this article an integrated force sensor based on a stress-sensing MOS transistor is introduced for applications in scanning force microscopy (SFM) . The sensor configuration will be described, and...

COSTA: A Computerised Support System for Emergency Technical Advice (1997)

Kobayashi, K., Ishigami, T., Akiyama, T.

If an accident at a nuclear facility escalates to an emergency, the emergency technical advisory body (ETAB) is required to provide technical advice to the national and local governments for...

FIBROUS PARTICLES GENERATOR FOR INHALATION TOXICITY STUDIES (1987)

TANAKA, I., AKIYAMA, T.

This short communication describes the generation of fibrous dust clouds by means of a fluidized bed dust generator with continuous screw feeder and overflow pipe previously developed by us (TANAKA...

A NEW DUST GENERATOR FOR INHALATION TOXICITY STUDIES (1984)

TANAKA, I., AKIYAMA, T.

A dust generator has been developed for use in animal exposure experiments, which is able to produce constant dust concentrations over long periods. The generator consists of a fluidized bed which is...

The design of an agent to bend DNA.

Akiyama, T, Hogan, M E

An artificial DNA bending agent has been designed to assess helix flexibility over regions as small as a protein binding site. Bending was obtained by linking a pair of 15-base-long triple helix...

G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes.

Kudoh, T, Ishidate, T, Moriyama, M, Toyoshima, K, Akiyama, T

WT1, the Wilms tumor-suppressor gene, maps to the human chromosomal region 11p13 and encodes a transcriptional repressor, WT1, implicated in controlling normal urogenital development. Microinjection...

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

Hamada, F, Aoki, M, Akiyama, T, Toyoshima, K

The interaction of Fc receptors with antibody-antigen complexes activates multiple biological functions in hematopoietic cells. Recently, protein-tyrosine phosphorylation has been suggested to be...

17 beta-estradiol mimics ligand activity of the c-erbB2 protooncogene product.

Matsuda, S, Kadowaki, Y, Ichino, M, Akiyama, T, Toyoshima, K, Yamamoto, T

We report here the physical and functional interaction of estrogen with the ErbB2 protein p185c-erbB2. The ErbB2 protein immunoprecipitated from estrogen-treated [10(-8) to 10(-6) M 17 beta-estradiol...

Phosphorylation of the retinoblastoma protein by cdk2.

Akiyama, T, Ohuchi, T, Sumida, S, Matsumoto, K, Toyoshima, K

The retinoblastoma gene product (the RB protein) is phosphorylated in a cell cycle-dependent manner and this modification is believed to be important for cells to progress through the cell cycle. We...

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

Satoh, T, Endo, M, Nakafuku, M, Akiyama, T, Yamamoto, T, Kaziro, Y

The ras gene product (p21) is a GTP-binding protein and has been thought to transduce signals regulating proliferation or differentiation of cells. Like other GTP-binding proteins, p21.GTP is an...

Identification of endo-beta-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase as cluster-dispersing enzymes in Staphylococcus aureus.

Sugai, M, Komatsuzawa, H, Akiyama, T, Hong, Y M, Oshida, T, Miyake, Y, ...

Two proteins which are capable of dispersing cell clusters of Staphylococcus aureus have been purified from a S. aureus FDA209P culture supernatant. Both of them were found to have bacteriolytic...

Purification and molecular characterization of glycylglycine endopeptidase produced by Staphylococcus capitis EPK1.

Sugai, M, Fujiwara, T, Akiyama, T, Ohara, M, Komatsuzawa, H, Inoue, S, ...

A novel staphylolytic enzyme, ALE-1, acting on Staphylococcus aureus, was purified from a Staphylococcus capitis EPK1 culture supernatant. The optimal pH range for staphylolytic activity was 7 to 9....

The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain.

Akiyama, T, Matsuda, S, Namba, Y, Saito, T, Toyoshima, K, Yamamoto, T

The mutant c-erbB-2 protein with Glu instead of Val-659 exhibited transforming activity in NIH 3T3 cells. This protein showed enhanced tyrosine kinase activity in vitro and enhanced...

Human c-fgr induces a monocyte-specific enzyme in NIH 3T3 cells.

Inoue, K, Wongsasant, B, Akiyama, T, Toyoshima, K

The mutant c-fgr protein (p58c-fgr/F523) containing Phe-523 instead of Tyr-523 exhibited transforming activity in NIH 3T3 cells like other protein-tyrosine kinases of the src family, but normal...

Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells.

Akiyama, T, Saito, T, Ogawara, H, Toyoshima, K, Yamamoto, T

Treatment of human adenocarcinoma MKN-7 cells with epidermal growth factor (EGF) or phorbol tetradecanoate acetate (TPA) stimulated phosphorylation of the c-erbB-2 gene product. EGF induced a rapid...

The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase.

Baeg, G H, Matsumine, A, Kuroda, T, Bhattacharjee, R N, Miyashiro, I, Toyoshima, K, ...

The APC gene is mutated in familial adenomatous polyposis (FAP) as well as in sporadic colorectal tumours. The product of the APC gene is a 300 kDa cytoplasmic protein associated with the adherence...

Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients.

Ikehata, F, Satoh, J, Nata, K, Tohgo, A, Nakazawa, T, Kato, I, ...

Cyclic ADP-ribose (cADPR) has been shown to be a mediator for intracellular Ca2+ mobilization for insulin secretion by glucose in pancreatic beta cells, and CD38 shows both ADP-ribosyl cyclase to...

Characterization of sodium dodecyl sulfate-stable Staphylococcus aureus bacteriolytic enzymes by polyacrylamide gel electrophoresis.

Sugai, M, Akiyama, T, Komatsuzawa, H, Miyake, Y, Suginaka, H

Profiles of the bacteriolytic activities of Staphylococcus aureus culture supernatants, sodium dodecyl sulfate cell extracts, LiCl cell extracts, cell wall extracts, and cell membranes were analyzed...

Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi-factor-dependent myeloid cell lines.

Koyasu, S, Tojo, A, Miyajima, A, Akiyama, T, Kasuga, M, Urabe, A, ...

Tyrosine phosphorylation of cellular proteins induced by various hematopoietic growth factors such as interleukin 3 (IL3), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4...

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

Matsuda, S, Kosako, H, Takenaka, K, Moriyama, K, Sakai, H, Akiyama, T, ...

MAP kinase is thought to play a pivotal role not only in the growth factor-stimulated signalling pathway but also in the M phase phosphorylation cascade downstream of MPF. MAP kinase is fully active...

The hyperpolarization of frog skeletal muscle fibres induced by removing potassium from the bathing medium

Akiyama, T., Grundfest, H.

1. The time course of changes in resting potential after removing K0 was studied in twenty-four single fibres and in 136 fibres from small bundle (two to four fibres) preparations of frog...

The design of an agent to bend DNA.

Akiyama, T, Hogan, M E

An artificial DNA bending agent has been designed to assess helix flexibility over regions as small as a protein binding site. Bending was obtained by linking a pair of 15-base-long triple helix...

G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes.

Kudoh, T, Ishidate, T, Moriyama, M, Toyoshima, K, Akiyama, T

WT1, the Wilms tumor-suppressor gene, maps to the human chromosomal region 11p13 and encodes a transcriptional repressor, WT1, implicated in controlling normal urogenital development. Microinjection...

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

Hamada, F, Aoki, M, Akiyama, T, Toyoshima, K

The interaction of Fc receptors with antibody-antigen complexes activates multiple biological functions in hematopoietic cells. Recently, protein-tyrosine phosphorylation has been suggested to be...

17 beta-estradiol mimics ligand activity of the c-erbB2 protooncogene product.

Matsuda, S, Kadowaki, Y, Ichino, M, Akiyama, T, Toyoshima, K, Yamamoto, T

We report here the physical and functional interaction of estrogen with the ErbB2 protein p185c-erbB2. The ErbB2 protein immunoprecipitated from estrogen-treated [10(-8) to 10(-6) M 17 beta-estradiol...

Phosphorylation of the retinoblastoma protein by cdk2.

Akiyama, T, Ohuchi, T, Sumida, S, Matsumoto, K, Toyoshima, K

The retinoblastoma gene product (the RB protein) is phosphorylated in a cell cycle-dependent manner and this modification is believed to be important for cells to progress through the cell cycle. We...

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

Satoh, T, Endo, M, Nakafuku, M, Akiyama, T, Yamamoto, T, Kaziro, Y

The ras gene product (p21) is a GTP-binding protein and has been thought to transduce signals regulating proliferation or differentiation of cells. Like other GTP-binding proteins, p21.GTP is an...

Identification of endo-beta-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase as cluster-dispersing enzymes in Staphylococcus aureus.

Sugai, M, Komatsuzawa, H, Akiyama, T, Hong, Y M, Oshida, T, Miyake, Y, ...

Two proteins which are capable of dispersing cell clusters of Staphylococcus aureus have been purified from a S. aureus FDA209P culture supernatant. Both of them were found to have bacteriolytic...

Purification and molecular characterization of glycylglycine endopeptidase produced by Staphylococcus capitis EPK1.

Sugai, M, Fujiwara, T, Akiyama, T, Ohara, M, Komatsuzawa, H, Inoue, S, ...

A novel staphylolytic enzyme, ALE-1, acting on Staphylococcus aureus, was purified from a Staphylococcus capitis EPK1 culture supernatant. The optimal pH range for staphylolytic activity was 7 to 9....

The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain.

Akiyama, T, Matsuda, S, Namba, Y, Saito, T, Toyoshima, K, Yamamoto, T

The mutant c-erbB-2 protein with Glu instead of Val-659 exhibited transforming activity in NIH 3T3 cells. This protein showed enhanced tyrosine kinase activity in vitro and enhanced...

Human c-fgr induces a monocyte-specific enzyme in NIH 3T3 cells.

Inoue, K, Wongsasant, B, Akiyama, T, Toyoshima, K

The mutant c-fgr protein (p58c-fgr/F523) containing Phe-523 instead of Tyr-523 exhibited transforming activity in NIH 3T3 cells like other protein-tyrosine kinases of the src family, but normal...

Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells.

Akiyama, T, Saito, T, Ogawara, H, Toyoshima, K, Yamamoto, T

Treatment of human adenocarcinoma MKN-7 cells with epidermal growth factor (EGF) or phorbol tetradecanoate acetate (TPA) stimulated phosphorylation of the c-erbB-2 gene product. EGF induced a rapid...

The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase.

Baeg, G H, Matsumine, A, Kuroda, T, Bhattacharjee, R N, Miyashiro, I, Toyoshima, K, ...

The APC gene is mutated in familial adenomatous polyposis (FAP) as well as in sporadic colorectal tumours. The product of the APC gene is a 300 kDa cytoplasmic protein associated with the adherence...

Autoantibodies against CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin- dependent diabetes patients.

Ikehata, F, Satoh, J, Nata, K, Tohgo, A, Nakazawa, T, Kato, I, ...

Cyclic ADP-ribose (cADPR) has been shown to be a mediator for intracellular Ca2+ mobilization for insulin secretion by glucose in pancreatic beta cells, and CD38 shows both ADP-ribosyl cyclase to...

Characterization of sodium dodecyl sulfate-stable Staphylococcus aureus bacteriolytic enzymes by polyacrylamide gel electrophoresis.

Sugai, M, Akiyama, T, Komatsuzawa, H, Miyake, Y, Suginaka, H

Profiles of the bacteriolytic activities of Staphylococcus aureus culture supernatants, sodium dodecyl sulfate cell extracts, LiCl cell extracts, cell wall extracts, and cell membranes were analyzed...

Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi-factor-dependent myeloid cell lines.

Koyasu, S, Tojo, A, Miyajima, A, Akiyama, T, Kasuga, M, Urabe, A, ...

Tyrosine phosphorylation of cellular proteins induced by various hematopoietic growth factors such as interleukin 3 (IL3), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 4...

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

Matsuda, S, Kosako, H, Takenaka, K, Moriyama, K, Sakai, H, Akiyama, T, ...

MAP kinase is thought to play a pivotal role not only in the growth factor-stimulated signalling pathway but also in the M phase phosphorylation cascade downstream of MPF. MAP kinase is fully active...

The hyperpolarization of frog skeletal muscle fibres induced by removing potassium from the bathing medium

Akiyama, T., Grundfest, H.

1. The time course of changes in resting potential after removing K0 was studied in twenty-four single fibres and in 136 fibres from small bundle (two to four fibres) preparations of frog...

Pharmacological profile of TP-680, a new cholecystokininA receptor antagonist.

Akiyama, T., Tachibana, I., Hirohata, Y., Shirohara, H., Yamamoto, M., Otsuki, M.

1. The pharmacological characteristics of a newly developed serine derivative (R)-1-[3-(3-carboxypyridine-2-yl) thio-2-(indol-2-yl)carbonylamino]propionyl-4-diphenylmethyl- piperazine (TP-680), a...

Ethylene oxide induces central-peripheral distal axonal degeneration of the lumbar primary neurones in rats.

Ohnishi, A, Inoue, N, Yamamoto, T, Murai, Y, Hori, H, Koga, M, ...

Wistar rats subjected to a single exposure lasting six hours to ethylene oxide (EO) at a concentration of 500 parts per million three times a week for 13 weeks developed ataxia in the hindlegs....

Randomised controlled trial of swaddling versus massage in the management of excessive crying in infants with cerebral injuries

Ohgi, S, Akiyama, T, Arisawa, K, Shigemori, K

Background: Infants with neonatal cerebral insults are susceptible to excessive crying as a result of difficulties with self-regulation.

Combined effect of navelbine with medroxyprogesterone acetate against human breast carcinoma MCF-7 cells in vitro.

Sugiyama, K., Shimizu, M., Akiyama, T., Ishida, H., Okabe, M., Tamaoki, T., ...

Navelbine (NVB, vinorelbine ditartrate, KW-2307), a new vinca alkaloid analogue, has been shown to be clinically effective against advanced breast cancer. In this report, the combined effect of NVB...