T. Hoshino

Details der Publikationsliste

Zeitraum

1980 - 2007

Anzahl

148

Co-Autoren

Bibliography (2007)

T. Okamoto, T. Kato, Y. Yokomizu, Y. Suzuoki, T. Tanaka, S. N. Hettiwatte, ...

sson, "Partial discharges studies using acoustic emission," 1994. [24] A. Tungkanawanich, E. Y. Hamid, Z. I. Kawasaki, and K. Matsuura, "Analysis of VHF-wideband electromagnetic noises...

Pressure Field Visualization on the Surface of a Square Cylinder with Pressure Sensitive Paints (2007)

Fukuyama, E., Hoshino, T., Iida, A., Brown, R. J., Jacobs, Peter, McIntyre, Tim, ...

Pressure Sensitive Paints (PSP) are one of the breakthrough technologies for the measurement of aerodynamic sound from automobiles. Potential problems in applying Pressure Sensitive Paints to...

Pressure Field Visualization on the Surface of a Square Cylinder with Pressure Sensitive Paints (2007)

Fukuyama, E., Hoshino, T., Iida, A., Brown, R. J.

Pressure Sensitive Paints (PSP) are one of the breakthrough technologies for the measurement of aerodynamic sound from automobiles. Potential problems in applying Pressure Sensitive Paints to...

Pressure Field Visualization on the Surface of a Square Cylinder with Pressure Sensitive Paints (2007)

Fukuyama, E., Hoshino, T., Iida, A., Brown, R. J.

Pressure Sensitive Paints (PSP) are one of the breakthrough technologies for the measurement of aerodynamic sound from automobiles. Potential problems in applying Pressure Sensitive Paints to...

Cloning of the astaxanthin synthase gene from Xanthophyllomyces dendrorhous (Phaffia rhodozyma) and its assignment as a beta-carotene 3-hydroxylase/4-ketolase (2006)

Ojima, K., Breitenbach, J., Visser, J.H., Setoguchi, Y., Tabata, K., Hoshino, T., ...

A gene has been cloned from Xanthophyllomyces dendrorhous by complementation of astaxanthin formation in a ß-carotene accumulating mutant. It consists of 3,166 bp and contains 17 introns. For the...

Semen quality of 324 fertile Japanese men (2006)

Iwamoto, T., Nozawa, S., Yoshiike, M., Hoshino, T., Baba, K., Matsushita, T., ...

BACKGROUND: A number of studies have indicated regional differences in semen quality. To examine the current status in Japan, we undertook a cross-sectional study on the semen quality of fertile...

Computational analysis of the transient movement of helices in sensory rhodopsin II (2005)

Sato, Y., Hata, M., Neya, S., Hoshino, T.

MD simulation of sensory rhodopsin II was executed for three intermediates (ground-state, K-state, M-state) appearing in its photocycle. We observed a large displacement of the cytoplasmic side of...

Semen quality of 324 fertile Japanese men (2005)

Iwamoto, T., Nozawa, S., Yoshiike, M., Hoshino, T., Baba, K., Matsushita, T., ...

BACKGROUND: A number of studies have indicated regional differences in semen quality. To examine the current status in Japan, we undertook a cross-sectional study on the semen quality of fertile...

Computational analysis of the transient movement of helices in sensory rhodopsin II (2004)

Sato, Y., Hata, M., Neya, S., Hoshino, T.

MD simulation of sensory rhodopsin II was executed for three intermediates (ground-state, K-state, M-state) appearing in its photocycle. We observed a large displacement of the cytoplasmic side of...

Recent technical trends of superconducting magnets in Japan, part I : Magnet data base and recent progress in magnet winding current density (1999)

Tsukamoto, Osami, Torii, S., Takao, T., Amemiya, N., Fukui, S., Hoshino, T., ...

The committee on applied superconducting apparatuses and characteristics of superconductors, the Institute of Electrical Engineers of Japan (IEEJ) has made a data base on low temperature...

Electromagnetic noise spectrum caused by partial discharge in air at high voltage substations (1998)

Hikita, M., Yamashita, H., Hoshino, T., Kato, T., Hayakawa, N., Ueda, T., ...

We investigated characteristics of electromagnetic spectrum caused by partial discharge (PD) in air at three different types of high voltage substations. From the measured results, we characterized...

Hadron Masses and Decay Constants with Wilson Quarks at $\beta=5.85$ and 6.0 (1995)

Iwasaki, Y., Kanaya, K., Yoshi{é}, T., Hoshino, T., Shirakawa, T., Oyanagi, Y., ...

We present results of a high statistics calculation of hadron masses and meson decay constants in the quenched approximation to lattice QCD with Wilson quarks at $\beta=$ 5.85 and 6.0 on $24^3 \times...

High statistics calculations of quenched QCD spectrum using various quark sources (1993)

Iwasaki, QCDPAX Collaboration: Y., Kanaya, K., Sakai, S., Yoshie, T., Hoshino, T., Shirakawa, T.

We present the results for the hadron spectrum calculated on 400 configurations using point source, wall source and 8-cubic sources, in quenched QCD with Wilson fermions at $\beta=6.0$ and $K=0.155$...

Contamination of Excited States in Quenched QCD Hadron Propagators (1992)

Iwasaki, QCDPAX Collaboration: Y., Kanaya, K., Sakai, S., Yoshie, T., Hoshino, T., Shirakawa, T., ...

Quenched QCD hadron spectrum is calculated with Wilson's quark action at $\beta=5.85$ and 6.0 on a $24^3 \times 54$ lattice. We discuss the problem of whether we have extracted the mass of the ground...

ELLIPSOMETRIC STUDY OF NUCLEATION AND GROWTH IN THE ANODIC FILM FORMATION ON Bi2 Te3 (1983)

Hoshino, T., Moritani, A., Nakai, J.

The present paper shows from the ellipsometric investigation that the anodic film formation on layered semiconductor Bi2Te3 proceeds through the two-dimensional nucleation and growth. The present...

ELLIPSOMETRIC STUDY OF NUCLEATION AND GROWTH IN THE ANODIC FILM FORMATION ON Bi2 Te3 (1983)

Hoshino, T., Moritani, A., Nakai, J.

The present paper shows from the ellipsometric investigation that the anodic film formation on layered semiconductor Bi2Te3 proceeds through the two-dimensional nucleation and growth. The present...

ELLIPSOMETRIC STUDY OF NUCLEATION AND GROWTH IN THE ANODIC FILM FORMATION ON Bi2 Te3 (1983)

Hoshino, T., Moritani, A., Nakai, J.

The present paper shows from the ellipsometric investigation that the anodic film formation on layered semiconductor Bi2Te3 proceeds through the two-dimensional nucleation and growth. The present...

Inward Diffusion of Oxygen on a Silicon Surface

星野, 忠次, Hoshino, Tyuji, Nishioka, Y.

Cluster computations with the density functional theory were performed to clarify the diffusion mechanism of an O atom adsorbed on a Si surface. The activation energy required for the oxygen...

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

Hoshi, M, Takashima, A, Noguchi, K, Murayama, M, Sato, M, Kondo, S, ...

According to the amyloid hypothesis for the pathogenesis of Alzheimer disease, beta-amyloid peptide (betaA) directly affects neurons, leading to neurodegeneration and tau phosphorylation. In rat...

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Takashima, A, Noguchi, K, Sato, K, Hoshino, T, Imahori, K

Pathological changes of Alzheimer disease are characterized by cerebral cortical atrophy as a result of degeneration and loss of neurons. Typical histological lesions include numerous senile plaques...

The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen.

Leveque, C, Hoshino, T, David, P, Shoji-Kasai, Y, Leys, K, Omori, A, ...

Immunoglobulin G fractions from patients with Lambert-Eaton myasthenic syndrome (LEMS), an autoimmune disease of neuromuscular transmission, immunoprecipitate 125I-labeled omega-conotoxin...

Cloning and nucleotide sequencing of the membrane-bound L-sorbosone dehydrogenase gene of Acetobacter liquefaciens IFO 12258 and its expression in Gluconobacter oxydans.

Shinjoh, M, Tomiyama, N, Asakura, A, Hoshino, T

Cloning and expression of the gene encoding Acetobacter liquefaciens IFO 12258 membrane-bound L-sorbosone dehydrogenase (SNDH) were studied. A genomic library of A. liquefaciens IFO 12258 was...

Characterization of a thermostable DNA photolyase from an extremely thermophilic bacterium, Thermus thermophilus HB27.

Kato, R, Hasegawa, K, Hidaka, Y, Kuramitsu, S, Hoshino, T

The photolyase gene from Thermus thermophilus was cloned and sequenced. The characteristic absorption and fluorescence spectra of the purified T. thermophilus photolyase suggested that the protein...

Molecular cloning and sequence analysis of the crtB gene of Thermus thermophilus HB27, an extreme thermophile producing carotenoid pigments.

Hoshino, T, Fujii, R, Nakahara, T

We have cloned and sequenced a 1.5-kb chromosomal fragment of Thermus thermophilus which promoted the overproduction of carotenoids in T. thermophilus. An open reading frame (ORF-A) coding for a...

Isolation of the braZ gene encoding the carrier for a novel branched-chain amino acid transport system in Pseudomonas aeruginosa PAO.

Hoshino, T, Kose-Terai, K, Uratani, Y

The braZ gene for a novel branched-chain amino acid transport system in Pseudomonas aeruginosa PAO was isolated and characterized. Determination of the nucleotide sequence showed that the braZ gene...

Cloning and nucleotide sequence of braC, the structural gene for the leucine-, isoleucine-, and valine-binding protein of Pseudomonas aeruginosa PAO.

Hoshino, T, Kose, K

The gene for the leucine-, isoleucine-, and valine-binding protein (LIVAT-BP) in Pseudomonas aeruginosa PAO was isolated, and its nucleotide sequence was determined. The gene consisted of 1,119...

Genetic transformation of the extreme thermophile Thermus thermophilus and of other Thermus spp.

Koyama, Y, Hoshino, T, Tomizuka, N, Furukawa, K

Genetic transformation of auxotrophs of the extreme thermophile Thermus thermophilus HB27 to prototrophy was obtained at high frequencies of 10(-2) to 10(-1) when proliferating cell populations were...

Pyocin R1 inhibits active transport in Pseudomonas aeruginosa and depolarizes membrane potential.

Uratani, Y, Hoshino, T

Pyocin R1, a bacteriocin of Pseudomonas aeruginosa, inhibited active transport of proline in the presence of high concentrations of malate and magnesium salt. Pyocin R1 did not affect the respiration...

Sodium-dependent transport of L-leucine in membrane vesicles prepared from Pseudomonas aeruginosa.

Hoshino, T, Kageyama, M

Membrane vesicles were prepared by osmotic lysis of spheroplasts of Pseudomonas aeruginosa strain P14, and the active transport of amino acids was studied. D-Glucose, gluconate, and L-malate...

Mutational separation of transport systems for branched-chain amino acids in Pseudomonas aeruginosa.

Hoshino, T, Kageyama, M

Several types of Pseudomonas aeruginosa mutants defective in the transport systems for branched-chain amino acids were isolated by selection for resistance to 5',5',5'-DL-trifluoroleucine, a leucine...

Isolation and characterization of a Pseudomonas aeruginosa PAO mutant defective in the structural gene for the LIVAT-binding protein.

Hoshino, T, Nishio, K

A mutant of Pseudomonas aeruginosa PAO which has a defect in the structural gene for a binding protein for leucine, isoleucine, valine, alanine, and threonine (LIVAT-binding protein) was isolated and...

Genetic mapping of bra genes affecting branched-chain amino acid transport in Pseudomonas aeruginosa.

Hoshino, T, Tsuda, M, Iino, T, Nishio, K, Kageyama, M

Pseudomonas aeruginosa PAO mutants defective in the transport systems for branched-chain amino acids were isolated and characterized. Two mutations in strains selected for trifluoroleucine...

Purification and properties of a binding protein for branched-chain amino acids in Pseudomonas aeruginosa.

Hoshino, T, Kageyama, M

A binding protein for branched-chain amino acids was purified to a homogeneous state from shock fluid of Pseudomonas aeruginosa PML14. It was a monomeric protein with an apparent molecular weight of...

Nucleotide sequence of Bacillus subtilis dnaB: a gene essential for DNA replication initiation and membrane attachment.

Hoshino, T, McKenzie, T, Schmidt, S, Tanaka, T, Sueoka, N

The complete nucleotide sequence of the Bacillus subtilis dnaB gene and its flanking regions was determined. The dnaB gene is essential for both replication initiation and membrane attachment of the...

Abnormal alkaline phosphatase of hepatic type in cerebrospinal fluid of a patient with intracranial metastasis from lung cancer.

Hoshino, T, Kumasaka, K, Kawano, K, Koyama, I, Arai-Fujimori, Y, Yamagishi, F, ...

High alkaline phosphatase (ALP) activity was found in the cerebrospinal fluid of a patient with intracranial metastases from adenocarcinoma of the lung. On agarose gel electrophoresis of the major...

Cloning, nucleotide sequences, and identification of products of the Pseudomonas aeruginosa PAO bra genes, which encode the high-affinity branched-chain amino acid transport system.

Hoshino, T, Kose, K

A DNA fragment of Pseudomonas aeruginosa PAO containing genes specifying the high-affinity branched-chain amino acid transport system (LIV-I) was isolated. The fragment contained the braC gene,...

Genetic analysis of the Pseudomonas aeruginosa PAO high-affinity branched-chain amino acid transport system by use of plasmids carrying the bra genes.

Hoshino, T, Kose, K

About 30 mutants of Pseudomonas aeruginosa PAO defective in the high-affinity branched-chain amino acid transport system (LIV-I) were isolated by the selection for resistance to 4-aza-DL-leucine, a...

Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP.

Duan, D S, Nagashima, T, Hoshino, T, Waldman, F, Pawlak, K, Sadee, W

Purine nucleoside phosphorylase (PNP; EC 2.4.2.1) deficiency is thought to cause T-lymphocyte depletion by accumulation of dG and dGTP, resulting in feedback inhibition of ribonucleotide reductase...

Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos.

Nagamatsu, S, Sawa, H, Inoue, N, Nakamichi, Y, Takeshima, H, Hoshino, T

This study was designed to determine whether glucose regulates the gene expression of glucose transporter GLUT3 in neurons. We examined the regulation of GLUT3 mRNA by glucose in vivo in mouse brain...

Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21.

Futatsugi, N, Hata, M, Hoshino, T, Tsuda, M

Quantum chemical computations using the ab initio molecular orbital (MO) method have been performed to investigate the molecular switching mechanism of Ras protein p21, which has an important role in...

A study on the mechanism of the proton transport in bacteriorhodopsin: the importance of the water molecule.

Murata, K, Fujii, Y, Enomoto, N, Hata, M, Hoshino, T, Tsuda, M

The mechanism of proton transport around the Schiff base in bacteriorhodopsin was investigated by ab initio molecular orbital (MO) calculations. Computations were performed for the case where there...

Theoretical studies of the ATP hydrolysis mechanism of myosin.

Okimoto, N, Yamanaka, K, Ueno, J, Hata, M, Hoshino, T, Tsuda, M

The ATP hydrolysis mechanism of myosin was studied using quantum chemical (QM) and molecular dynamics calculations. The initial model compound for QM calculations was constructed on the basis of the...

Cloning and Nucleotide Sequencing of the Membrane-Bound l-Sorbosone Dehydrogenase Gene of Acetobacter liquefaciens IFO 12258 and Its Expression in Gluconobacter oxydans

Shinjoh, M., Tomiyama, N., Asakura, A., Hoshino, T.

Volume 61, no. 2, p. 419, column 1, lines 15-19: this sentence should read as follows. "The alcohol dehydrogenase and glucose dehydrogenase have a common region reported to be related to...

Transport systems for branched-chain amino acids in Pseudomonas aeruginosa.

Hoshino, T

The cells of Pseudomonas aeruginosa showed high activity for leucine transport in the absence of Na+, giving a Km value of 0.34 microM. In the presence of Na+, however, two Km values, 0.37 microM...

Ca(2+)-induced Ca2+ release and its activation in response to a single action potential in rabbit otic ganglion cells.

Yoshizaki, K, Hoshino, T, Sato, M, Koyano, H, Nohmi, M, Hua, S Y, ...

1. Ryanodine-sensitive intracellular Ca2+ release activated by Ca2+ entry was studied with fura-2 fluorescence and intracellular voltage recording techniques in rabbit otic ganglion cells. 2. The...

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

Hoshi, M, Takashima, A, Noguchi, K, Murayama, M, Sato, M, Kondo, S, ...

According to the amyloid hypothesis for the pathogenesis of Alzheimer disease, beta-amyloid peptide (betaA) directly affects neurons, leading to neurodegeneration and tau phosphorylation. In rat...

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Takashima, A, Noguchi, K, Sato, K, Hoshino, T, Imahori, K

Pathological changes of Alzheimer disease are characterized by cerebral cortical atrophy as a result of degeneration and loss of neurons. Typical histological lesions include numerous senile plaques...

The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen.

Leveque, C, Hoshino, T, David, P, Shoji-Kasai, Y, Leys, K, Omori, A, ...

Immunoglobulin G fractions from patients with Lambert-Eaton myasthenic syndrome (LEMS), an autoimmune disease of neuromuscular transmission, immunoprecipitate 125I-labeled omega-conotoxin...

Cloning and nucleotide sequencing of the membrane-bound L-sorbosone dehydrogenase gene of Acetobacter liquefaciens IFO 12258 and its expression in Gluconobacter oxydans.

Shinjoh, M, Tomiyama, N, Asakura, A, Hoshino, T

Cloning and expression of the gene encoding Acetobacter liquefaciens IFO 12258 membrane-bound L-sorbosone dehydrogenase (SNDH) were studied. A genomic library of A. liquefaciens IFO 12258 was...

Characterization of a thermostable DNA photolyase from an extremely thermophilic bacterium, Thermus thermophilus HB27.

Kato, R, Hasegawa, K, Hidaka, Y, Kuramitsu, S, Hoshino, T

The photolyase gene from Thermus thermophilus was cloned and sequenced. The characteristic absorption and fluorescence spectra of the purified T. thermophilus photolyase suggested that the protein...

Molecular cloning and sequence analysis of the crtB gene of Thermus thermophilus HB27, an extreme thermophile producing carotenoid pigments.

Hoshino, T, Fujii, R, Nakahara, T

We have cloned and sequenced a 1.5-kb chromosomal fragment of Thermus thermophilus which promoted the overproduction of carotenoids in T. thermophilus. An open reading frame (ORF-A) coding for a...

Isolation of the braZ gene encoding the carrier for a novel branched-chain amino acid transport system in Pseudomonas aeruginosa PAO.

Hoshino, T, Kose-Terai, K, Uratani, Y

The braZ gene for a novel branched-chain amino acid transport system in Pseudomonas aeruginosa PAO was isolated and characterized. Determination of the nucleotide sequence showed that the braZ gene...

Cloning and nucleotide sequence of braC, the structural gene for the leucine-, isoleucine-, and valine-binding protein of Pseudomonas aeruginosa PAO.

Hoshino, T, Kose, K

The gene for the leucine-, isoleucine-, and valine-binding protein (LIVAT-BP) in Pseudomonas aeruginosa PAO was isolated, and its nucleotide sequence was determined. The gene consisted of 1,119...

Genetic transformation of the extreme thermophile Thermus thermophilus and of other Thermus spp.

Koyama, Y, Hoshino, T, Tomizuka, N, Furukawa, K

Genetic transformation of auxotrophs of the extreme thermophile Thermus thermophilus HB27 to prototrophy was obtained at high frequencies of 10(-2) to 10(-1) when proliferating cell populations were...

Pyocin R1 inhibits active transport in Pseudomonas aeruginosa and depolarizes membrane potential.

Uratani, Y, Hoshino, T

Pyocin R1, a bacteriocin of Pseudomonas aeruginosa, inhibited active transport of proline in the presence of high concentrations of malate and magnesium salt. Pyocin R1 did not affect the respiration...

Transport systems for branched-chain amino acids in Pseudomonas aeruginosa.

Hoshino, T

The cells of Pseudomonas aeruginosa showed high activity for leucine transport in the absence of Na+, giving a Km value of 0.34 microM. In the presence of Na+, however, two Km values, 0.37 microM...

Sodium-dependent transport of L-leucine in membrane vesicles prepared from Pseudomonas aeruginosa.

Hoshino, T, Kageyama, M

Membrane vesicles were prepared by osmotic lysis of spheroplasts of Pseudomonas aeruginosa strain P14, and the active transport of amino acids was studied. D-Glucose, gluconate, and L-malate...

Mutational separation of transport systems for branched-chain amino acids in Pseudomonas aeruginosa.

Hoshino, T, Kageyama, M

Several types of Pseudomonas aeruginosa mutants defective in the transport systems for branched-chain amino acids were isolated by selection for resistance to 5',5',5'-DL-trifluoroleucine, a leucine...

Isolation and characterization of a Pseudomonas aeruginosa PAO mutant defective in the structural gene for the LIVAT-binding protein.

Hoshino, T, Nishio, K

A mutant of Pseudomonas aeruginosa PAO which has a defect in the structural gene for a binding protein for leucine, isoleucine, valine, alanine, and threonine (LIVAT-binding protein) was isolated and...

Genetic mapping of bra genes affecting branched-chain amino acid transport in Pseudomonas aeruginosa.

Hoshino, T, Tsuda, M, Iino, T, Nishio, K, Kageyama, M

Pseudomonas aeruginosa PAO mutants defective in the transport systems for branched-chain amino acids were isolated and characterized. Two mutations in strains selected for trifluoroleucine...

Purification and properties of a binding protein for branched-chain amino acids in Pseudomonas aeruginosa.

Hoshino, T, Kageyama, M

A binding protein for branched-chain amino acids was purified to a homogeneous state from shock fluid of Pseudomonas aeruginosa PML14. It was a monomeric protein with an apparent molecular weight of...

Nucleotide sequence of Bacillus subtilis dnaB: a gene essential for DNA replication initiation and membrane attachment.

Hoshino, T, McKenzie, T, Schmidt, S, Tanaka, T, Sueoka, N

The complete nucleotide sequence of the Bacillus subtilis dnaB gene and its flanking regions was determined. The dnaB gene is essential for both replication initiation and membrane attachment of the...

Abnormal alkaline phosphatase of hepatic type in cerebrospinal fluid of a patient with intracranial metastasis from lung cancer.

Hoshino, T, Kumasaka, K, Kawano, K, Koyama, I, Arai-Fujimori, Y, Yamagishi, F, ...

High alkaline phosphatase (ALP) activity was found in the cerebrospinal fluid of a patient with intracranial metastases from adenocarcinoma of the lung. On agarose gel electrophoresis of the major...

Cloning, nucleotide sequences, and identification of products of the Pseudomonas aeruginosa PAO bra genes, which encode the high-affinity branched-chain amino acid transport system.

Hoshino, T, Kose, K

A DNA fragment of Pseudomonas aeruginosa PAO containing genes specifying the high-affinity branched-chain amino acid transport system (LIV-I) was isolated. The fragment contained the braC gene,...

Genetic analysis of the Pseudomonas aeruginosa PAO high-affinity branched-chain amino acid transport system by use of plasmids carrying the bra genes.

Hoshino, T, Kose, K

About 30 mutants of Pseudomonas aeruginosa PAO defective in the high-affinity branched-chain amino acid transport system (LIV-I) were isolated by the selection for resistance to 4-aza-DL-leucine, a...

Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP.

Duan, D S, Nagashima, T, Hoshino, T, Waldman, F, Pawlak, K, Sadee, W

Purine nucleoside phosphorylase (PNP; EC 2.4.2.1) deficiency is thought to cause T-lymphocyte depletion by accumulation of dG and dGTP, resulting in feedback inhibition of ribonucleotide reductase...

Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos.

Nagamatsu, S, Sawa, H, Inoue, N, Nakamichi, Y, Takeshima, H, Hoshino, T

This study was designed to determine whether glucose regulates the gene expression of glucose transporter GLUT3 in neurons. We examined the regulation of GLUT3 mRNA by glucose in vivo in mouse brain...

Ca(2+)-induced Ca2+ release and its activation in response to a single action potential in rabbit otic ganglion cells.

Yoshizaki, K, Hoshino, T, Sato, M, Koyano, H, Nohmi, M, Hua, S Y, ...

1. Ryanodine-sensitive intracellular Ca2+ release activated by Ca2+ entry was studied with fura-2 fluorescence and intracellular voltage recording techniques in rabbit otic ganglion cells. 2. The...

Ab initio study of the role of lysine 16 for the molecular switching mechanism of Ras protein p21.

Futatsugi, N, Hata, M, Hoshino, T, Tsuda, M

Quantum chemical computations using the ab initio molecular orbital (MO) method have been performed to investigate the molecular switching mechanism of Ras protein p21, which has an important role in...

A study on the mechanism of the proton transport in bacteriorhodopsin: the importance of the water molecule.

Murata, K, Fujii, Y, Enomoto, N, Hata, M, Hoshino, T, Tsuda, M

The mechanism of proton transport around the Schiff base in bacteriorhodopsin was investigated by ab initio molecular orbital (MO) calculations. Computations were performed for the case where there...

Theoretical studies of the ATP hydrolysis mechanism of myosin.

Okimoto, N, Yamanaka, K, Ueno, J, Hata, M, Hoshino, T, Tsuda, M

The ATP hydrolysis mechanism of myosin was studied using quantum chemical (QM) and molecular dynamics calculations. The initial model compound for QM calculations was constructed on the basis of the...

Cloning and Nucleotide Sequencing of the Membrane-Bound l-Sorbosone Dehydrogenase Gene of Acetobacter liquefaciens IFO 12258 and Its Expression in Gluconobacter oxydans

Shinjoh, M., Tomiyama, N., Asakura, A., Hoshino, T.

Volume 61, no. 2, p. 419, column 1, lines 15-19: this sentence should read as follows. "The alcohol dehydrogenase and glucose dehydrogenase have a common region reported to be related to...

Spontaneous resolution of a dissection of the descending aorta after medical treatment with a beta blocker and a calcium antagonist.

Hoshino, T, Ohmae, M, Sakai, A

A 58 year old man experienced an attack of squeezing chest pain. A contrast enhanced computed tomographic scan showed acute dissection of the descending aorta. Treatment with metoprolol and...

Spontaneous production of various cytokines except IL-4 from CD4+ T cells in the affected organs of sarcoidosis patients.

Hoshino, T, Itoh, K, Gouhara, R, Yamada, A, Tanaka, Y, Ichikawa, Y, ...

We investigated surface antigens and spontaneous cytokine production of T cells from bronchoalveolar lavage fluid (BALF) and aqueous humor (AH) from pulmonary sarcoidosis patients for a better...

OKT4+ and OKT8+ T lymphocytes produce soluble factors that can modulate growth and differentiation of human B cells.

Sakane, T, Ueda, Y, Suzuki, N, Niwa, Y, Hoshino, T, Tsunematsu, T

The human T cell subset(s) responsible for the production of soluble factors that can modulate B cell growth and B cell differentiation was investigated in the present study. For this purpose, highly...

Non-restricted T cell receptor (TCR)-Vα and -Vβ gene usage in patients with pulmonary sarcoidosis

HOSHINO, T, SUZUKI, R, TSURUTA, Y, MATSUTANI, T, KIKUCHI, M, KAWAMOTO, M, ...

Sarcoidosis is a systemic granulomatous disease of unknown etiology characterized by the pronounced accumulation of CD4+ T cells and macrophages in the affected organs. TCR variable (V)α and Vβ...

Computational analysis of the transient movement of helices in sensory rhodopsin II

Sato, Y., Hata, M., Neya, S., Hoshino, T.

MD simulation of sensory rhodopsin II was executed for three intermediates (ground-state, K-state, M-state) appearing in its photocycle. We observed a large displacement of the cytoplasmic side of...

Prevalence of mitochondrial gene mutations among hearing impaired patients

Usami, S., Abe, S., Akita, J., Namba, A., Shinkawa, H., Ishii, M., ...

The frequency of three mitochondrial point mutations, 1555A→G, 3243A→G, and 7445A→G, known to be associated with hearing impairment, was examined using restriction fragment length polymorphism...

Expression of angiogenic factors predicts response to chemoradiotherapy and prognosis of oesophageal squamous cell carcinoma

Shimada, H, Hoshino, T, Okazumi, S, Matsubara, H, Funami, Y, Nabeya, Y, ...

The ability to predict patients' responses to chemoradiotherapy by analyzing pre-treatment biopsy specimens would be valuable for managing oesophageal squamous-cell cancer. To this end, the...

Analysis of clonogenic human brain tumour cells: preliminary results of tumour sensitivity testing with BCNU.

Rosenblum, M. L., Dougherty, D. A., Deen, D. F., Hoshino, T., Wilson, C. B.

Biopsies from 6 patients with glioblastoma multiforme were disaggregated and single cells were treated in vitro with various concentrations of BCNU and plated for cell survival. One patient's cells...