Valle, J.W., Wasan, H., Johnson, P., Jones, E., Dixon, L., Swindell, R., ...
Background: we assessed the activity of gemcitabine (G) and cisplatin/gemcitabine (C/G) in patients with locally advanced (LA) or metastatic (M) (advanced) biliary cancers (ABC) for whom there is no...
Chau, I., Norman, A.R., Cunningham, D., Oates, J., Hawkins, R., Iveson, T., ...
Background: it is unclear if differential chemotherapy effects exist on overall survival (OS), response rate (RR) and toxicity depending on primary tumour origin [oesophageal versus...
Chau, I., Norman, A. R., Cunningham, D., Oates, J., Hawkins, R., Iveson, T., ...
Background: It is unclear if differential chemotherapy effects exist on overall survival (OS), response rate (RR) and toxicity depending on primary tumour origin [oesophageal versus...
Capecitabine and oxaliplatin for advanced esophagogastric cancer (2008)
Cunningham, D., Starling, N., Rao, S., Iveson, T., Nicolson, M., Coxon, F., ...
Background: We evaluated capecitabine (an oral fluoropyrimidine) and oxaliplatin (a platinum compound) as alternatives to infused fluorouracil and cisplatin, respectively, for untreated advanced...
Michels, J., Geldart, T., Darby, A., Craddock, L., Iveson, A., Richardson, L., ...
Aims To investigate the combination of raltitrexed and mitomycin-C as first-line chemotherapy treatment in patients with advanced colorectal cancer. Materials and methods A phase II study. Results In...
An unusual differential diagnosis of penile warts: metastases from rectal carcinoma (2006)
Cathomas, R., Geldart, T.R., Iveson, T., Singh, N., Rowen, D.
Patients with penile lesions, such as virally induced papillomata, frequently present to genitourinary medicine clinics and general practitioners. Their diagnosis is usually based on clinical...
Trumper, M., Ross, P.J., Cunningham, D., Norman, A.R., Hawkins, R., Seymour, M., ...
The aim of this study was to determine the benefits of chemotherapy for oesophago-gastric cancer (OGC) in patients 70 years and above ( >= 70) in comparison to younger patients. 1080 patients were...
Trumper, M., Ross, P.J., Cunningham, D., Norman, A.R., Hawkins, R., Seymour, M., ...
The aim of this study was to determine the benefits of chemotherapy for oesophago-gastric cancer (OGC) in patients 70 years and above (70) in comparison to younger patients. 1080 patients were...
Management of advanced colorectal cancer: state of the art (2006)
Colorectal cancer ( CRC) caused over 500 000 deaths worldwide in 2002. Recent advances in the treatment of advanced disease include the incorporation of two new cytotoxic agents, irinotecan and...
K Sumpter, C Harper-Wynne, D Cunningham, S Rao, N Tebbutt, A R Norman, ...
Chau, I., Norman, A.R., Cunningham, D., Tait, D., Ross, P.J., Iveson, T., ...
Background: We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of protracted venous infusion (PVI) 5-fluorouracil (5-FU) against the standard bolus monthly...
Sumpter, K., Harper-Wynne, C., Cunningham, D., Rao, S., Tebbutt, N., Norman, A.R., ...
The purpose of the study was to establish the optimal dose of capecitabine (X) to be used within a multicentre, randomised study evaluating the potential roles of oxaliplatin (O) and X in chemonaive...
Chau, I., Norman, A. R., Cunningham, D., Tait, D., Ross, P. J., Iveson, T., ...
Background: We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of protracted venous infusion (PVI) 5-fluorouracil (5-FU) against the standard bolus monthly...
Chau, I., Norman, A. R., Cunningham, D., Tait, D., Ross, P. J., Iveson, T., ...
Background: We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of protracted venous infusion (PVI) 5-fluorouracil (5-FU) against the standard bolus monthly...
Rao, S., Cunningham, D., De Gramont, A., Scheithauer, W., Smakal, M., Humblet, Y., ...
Purpose: To determine whether R115777 improves survival in patients with refractory advanced colorectal cancer (CRC) in a multicenter, double-blind, prospective randomized study. Patients and...
Saini, A., Norman, A.R., Cunningham, D., Chau, I., Hill, M., Tait, D., ...
We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of 5-fluorouracil (5-FU) delivered by protracted intravenous infusion (PVI 5-FU) against the standard...
Assersohn, L., Norman, A.R., Cunningham, D., Iveson, T., Seymour, M., Hickish, T., ...
No standard regimen has been identified for patients with a carcinoma of unknown primary (CUP). This study compared protracted venous infusion 5-fluorouracil (PVI 5-FU) with or without mitomycin C...
Ross, P., Nicolson, M., Cunningham, D., Valle, J., Seymour, M., Harper, P., ...
Purpose: We report the results of a prospectively randomized study that compared the combination of epirubicin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) (ECF) with the...
Tebbutt, N.C., Norman, A., Cunningham, D., Iveson, T., Seymour, M., Hickish, T., ...
Background: this randomised study compared protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin C (MMC) in patients with advanced oesophago-gastric cancer. Patients and...
Tebbutt, N. C., Norman, A., Cunningham, D., Iveson, T., Seymour, M., Hickish, T., ...
Background: This randomised study compared protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin C (MMC) in patients with advanced oesophago-gastric cancer. Patients and...
Clarke-Pearson, D.L., Van Le, L., Iveson, T., Whitney, C.W., Hanjani, P., Kristensen, G., ...
Purpose: To evaluate oral topotecan as single-agent, second-line therapy in patients with ovarian cancer previously treated with a platinum-based regimen. Patients and Methods: Patients (N = 116)...
Ross, P., Norman, A., Cunningham, D., Webb, A., Iveson, T., Padhani, A., ...
Background To compare protracted venous infusion (PVI) 5-fluorouracil (5-FU) with and without mitomycin C (MMC) in a prospectively randomised study and analyse for tumour response, survival, toxicity...
Bell, J. B., Barfoot, R., Iveson, T., Powles, R. L., Millar, B. C.
In a study of 29 patients who were receiving or had received interferon alpha 2b (IFN-alpha 2b) as maintenance therapy for multiple myeloma, antibodies were detected in 58% (17/29) of patients...
Management of advanced colorectal cancer: state of the art
Colorectal cancer (CRC) caused over 500 000 deaths worldwide in 2002. Recent advances in the treatment of advanced disease include the incorporation of two new cytotoxic agents, irinotecan and...
Sumpter, K, Harper-Wynne, C, Cunningham, D, Rao, S, Tebbutt, N, Norman, A R, ...
The purpose of the study was to establish the optimal dose of capecitabine (X) to be used within a multicentre, randomised study evaluating the potential roles of oxaliplatin (O) and X in chemonaive...