Fully Compatible Integration of High Density Embedded DRAM with 65nm CMOS Technology (CMOS5) (2009)
Y. Matsubara, M. Habu, S. Matsuda, K. Honda, E. Morifuji, T. Yoshida, ...
65nm node SoC technology has been achieved to show good yield of 8M bit DRAM ADM using tapered BF2 implantation without additional mask step, which cell size is 0.11um 2 [1], with 3 layers hybrid...
PERIODONTAL TREATMENT BY LOCAL DRUG DELIVERY USING RESORBABLE BASE MATERIAL (2009)
T. Noguchi, M. Fukuda, I. Ishikawa
The effects of local drug delivery to the subgingival plaque flora using resorbable base material were evaluated by the study of microbial composition in periodontal pockets and clinical...
Takeshima, N., Miyakawa, H., Okuda, K., Hattori, S., Hagiwara, S., Takatani, J., ...
Background No data for patients with failed back surgery syndrome (FBSS) based on the location of adhesions separated by epiduroscopic adhesiolysis have been reported. Methods We performed...
SHPS-1/SIRP1 alpha contributes to interleukin-6 signalling (2008)
Sobota, R. M., Müller, P. J., Khouri, C., Ullrich, A., Poli, V., Noguchi, T., ...
Energy Transfer between Throats from a 10d Perspective (2007)
Harling, B. V., Hebecker, A., Noguchi, T.
Strongly warped regions, also known as throats, are a common feature of the type IIB string theory landscape. If one of the throats is heated during cosmological evolution, the energy is subsequently...
Ultrahigh electron emissive carbon nanotubes with nano-sized RuO2 particles deposition (2007)
Knibbe, R, Nogita, K, Drennan, J, Noguchi, T, Tatenuma, K, Liu, P, ...
Multi-wall carbon nanotubes (MWNTs) have a great commercial potential as electron field emitters, but suffer from fundamental problems such as stability and brightness. By depositing the MWNTs with...
Ultrahigh electron emissive carbon nanotubes with nano-sized RuO2 particles deposition (2007)
Kazuhiro, N., Drennan, J., Knibbe, R., Noguchi, T., Tatenuma, K., Liu, P., ...
Multi-wall carbon nanotubes (MWNTs) have a great commercial potential as electron field emitters, but suffer from fundamental problems such as stability and brightness. By depositing the MWNTs with...
Ultrahigh electron emissive carbon nanotubes with nano-sized RuO2 particles deposition (2007)
Kazuhiro, N., Drennan, J., Knibbe, R., Noguchi, T., Tatenuma, K., Liu, P., ...
Multi-wall carbon nanotubes (MWNTs) have a great commercial potential as electron field emitters, but suffer from fundamental problems such as stability and brightness. By depositing the MWNTs with...
Spatiotemporal Patterns of Movement-Related Fields in Stroke Patients (2006)
K Kotani, Y Kinomoto, M Yamada, J Deguchi, M Tonoike, K Horii, ...
In this study, brain functions in stroke patients and normal subjects were analyzed by observing neuromagnetic fields during button pressing tasks. The measurements included force measurement, visual...
Spatiotemporal Patterns of Movement-Related Fields in Stroke Patients (2006)
K Kotani, Y Kinomoto, M Yamada, J Deguchi, M Tonoike, K Horii, ...
In this study, brain functions in stroke patients and normal subjects were analyzed by observing neuromagnetic fields during button pressing tasks. The measurements included force measurement, visual...
Spatiotemporal Patterns of Movement-Related Fields in Stroke Patients (2006)
K Kotani, Y Kinomoto, M Yamada, J Deguchi, M Tonoike, K Horii, ...
In this study, brain functions in stroke patients and normal subjects were analyzed by observing neuromagnetic fields during button pressing tasks. The measurements included force measurement, visual...
Spatiotemporal Patterns of Movement-Related Fields in Stroke Patients (2006)
K Kotani, Y Kinomoto, M Yamada, J Deguchi, M Tonoike, K Horii, ...
In this study, brain functions in stroke patients and normal subjects were analyzed by observing neuromagnetic fields during button pressing tasks. The measurements included force measurement, visual...
Machida, T., Kamijo, Y., Harada, K., Noguchi, T., Saito, R., Kato, T., ...
The spatial variation of the local density of states in optimally doped Bi$_{2}$Sr$_{1.6}$La$_{0.4}$CuO$_{6+\delta}$ (superconducting transition temperature is 34 K) is studied by scanning tunneling...
Aung, P. P., Oue, N., Mitani, Y., Nakayama, H., Yoshida, K., Noguchi, T., ...
Gastric cancer (GC) is one of the most common malignancies worldwide. Genes expressed only in cancer tissue will be useful molecular markers for diagnosis and may also be good therapeutic targets....
Salam, MA, Noguchi, T, Pothitan, R
The original publication is available at www.springerlink.com
Noble gas study of the Dhofar 018 howardite (2005)
Nakashima, D., Herrmann, S., Ott, U., Nakamura, T., Noguchi, T.
Tsuji, T, Noguchi, T, Niino, H, Matsuoka, T, Nakamura, Y, Tokuyama, H, ...
Collagenous matrices as release carriers of exogenous growth factors (2004)
Kanematsu, A, Yamamoto, S, Ozeki, M, Noguchi, T, Kanatani, I, Ogawa, O, ...
Highly functional carbon materials impregnated with nano-size RuO2 particle (2003)
Tatenuma, K., Noguchi, T., Amano, M., Taguchi, T., Nogita, K., Drennan, J., ...
Highly functional carbon materials impregnated with nano-size RuO2 particle (2003)
Tatenuma, K., Noguchi, T., Amano, M., Taguchi, T., Nogita, K., Drennan, J., ...
Sfermion Mass Degeneracy, Superconformal Dynamics and Supersymmetric Grand Unified Theories (2002)
Kobayashi, T., Nakano, H., Noguchi, T., Terao, H.
We discuss issues in a scenario where hierarchical Yukawa couplings are generated through the strong dynamics of superconformal field theories ~SCFTs!. Independently of the mediation mechanism of...
Miyasu, T, Noguchi, T, Hamasaki, A, Sasaki, R, Ozawa, Y, ...
Adipose tissue expresses a variety of genes including tumor necrosis factor alpha and type-1 plasminogen activator inhibitor (PAI-1); and these factors, produced by adipocytes, may be associated with...
Atomic Carbon and CO Isotope Emission in the Vicinity of DR15 (2001)
Oka, T., Yamamoto, S., Iwata, M., Maezawa, H., Ikeda, M., Ito, T., ...
We present observations of the 3P1-3P0 fine structure transition of atomic carbon [CI], the J=3-2 transition of CO, as well as of the J=1-0 transitions of 13CO and C18O toward DR15, an HII region...
One-loop analyses of lattice QCD with the overlap Dirac operator (1999)
Ishibashi, M., Kikukawa, Y., Noguchi, T., Yamada, A.
We discuss the weak coupling expansion of lattice QCD with the overlap Dirac operator. The Feynman rules for lattice QCD with the overlap Dirac operator are derived and the quark self-energy and...
Brane fluctuations and suppression of Kaluza-Klein mode couplings (1999)
Bando, M., Kugo, T., Noguchi, T., Yoshioka, K.
In higher dimensional models where the gauge and gravity fields live in the bulk and the matter fields only in a brane, we point out the importance of the brane (transverse) coordinate modes, which...
Low energy effective action of domain-wall fermion and the Ginsparg-Wilson relation (1999)
We derive the effective action of the light fermion field of the domain-wall fermion, which is referred as $q(x)$ by Furman and Shamir. The inverse of the effective Dirac operator turns out to be...
Chin, K, Kita, H, Noguchi, T, Otsuka, N, Tsuboi, T, Nakamura, T, ...
Matsui, M., Matsui, K., Kawasaki, Y., Oda, Y., Noguchi, T., Kitagawa, Y., ...
Stevioside, a constituent of Stevia rebaudiana, is commonly used as a non-caloric sugar substitute in Japan. The genetic toxicities of stevioside and its aglycone, steviol, were examined with seven...
Electron-dense Regions in Dividing Mitochondria of a Green Alga, Scenedesmus acutus (1993)
The dividing and the constricted regions of mitochondria in a green alga, Scenedesmus acutus , were studied by electron microscopy. Electron-dense substances were always visible in these specific...
Obesity and lipid profiles in middle aged men and women in Tanzania (1970)
Njelekela, M. A., Negishi, H., Nara, Y., Sato, T., Tomohiro, M., Kuga, S., ...
Objective: To examine the relationship between obesity and lipid profiles and to compare the effects of total obesity and central adiposity on lipids in three locations in Tanzania. Design:...
The Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis.
Klahre, U, Noguchi, T, Fujioka, S, Takatsuto, S, Yokota, T, Nomura, T, ...
We have identified the function of the Arabidopsis DIMINUTO/DWARF1 (DIM/DWF1) gene by analyzing the dim mutant, a severe dwarf with greatly reduced fertility. Both the mutant phenotype and gene...
Choe, S, Noguchi, T, Fujioka, S, Takatsuto, S, Tissier, C P, Gregory, B D, ...
Lesions in brassinosteroid (BR) biosynthetic genes result in characteristic dwarf phenotypes in plants. Understanding the regulation of BR biosynthesis demands continued isolation and...
The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis.
Fujioka, S, Li, J, Choi, Y H, Seto, H, Takatsuto, S, Noguchi, T, ...
The Arabidopsis DEETIOLATED2 (DET2) gene has been cloned and shown to encode a protein that shares significant sequence identity with mammalian steroid 5 alpha-reductases. Loss of DET2 function...
Nishihara, T, Ueda, N, Amano, K, Ishihara, Y, Hayakawa, H, Kuroyanagi, T, ...
The mechanism of osteoclast-like cell formation induced by periodontopathic bacterium Actinobacillus actinomycetemcomitans Y4 (serotype b) capsular-polysaccharide-like polysaccharide (capsular-like...
Matsuura, M, Noguchi, T, Yamaguchi, D, Aida, T, Asayama, M, Takahashi, H, ...
The sre gene (ORF469) of the R4 phage encodes a protein similar to the resolvase-DNA invertase family proteins. Insertional gene disruption of sre prevented a lysogen from entering the lytic cycle,...
Presence of Tetrodotoxin and Tetrodotoxin-Producing Bacteria in Freshwater Sediments
Do, H. K., Hamasaki, K., Ohwada, K., Simidu, U., Noguchi, T., Shida, Y., ...
The occurrence of tetrodotoxin (TTX) in sediment from Lake Suwa, Japan, was confirmed by a tissue culture assay, high-performance liquid chromatography, and gas chromatography-mass spectrometry....
Pharmacokinetics of cefpiramide (SM-1652) in humans.
Nakagawa, K, Koyama, M, Matsui, H, Ikeda, C, Yano, K, Nakatsuru, N, ...
The pharmacokinetics of cefpiramide (SM-1652) were studied after the intravenous administration of single or multiple doses to 21 healthy volunteers. The cefpiramide concentration in plasma at time...
Marine bacteria which produce tetrodotoxin.
Simidu, U, Noguchi, T, Hwang, D F, Shida, Y, Hashimoto, K
A number of type strains of marine bacteria, including members of the family Vibrionaceae, were cultured and examined for tetrodotoxin productivity by high-performance liquid chromatography and gas...
Fujioka, Y, Matozaki, T, Noguchi, T, Iwamatsu, A, Yamao, T, Takahashi, N, ...
Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, that contain Src homology 2 (SH2) domains play important roles in growth factor and cytokine signal transduction pathways. A protein...
Amano, K, Nishihara, T, Shibuya, N, Noguchi, T, Koga, T
A serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b) was extracted from whole cells by autoclaving. The extract was purified by chromatography on...
Koga, T, Nishihara, T, Fujiwara, T, Nisizawa, T, Okahashi, N, Noguchi, T, ...
Lipopolysaccharides (LPSs) were isolated from Bacteroides gingivalis and Escherichia coli by the phenol-water and butanol-water procedures. The phenol-water-extracted LPS from B. gingivalis 381 was...
Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter.
Lazo, P S, Dorfman, K, Noguchi, T, Mattéi, M G, Bravo, R
We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene. By deletion analysis we have characterized a...
Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b.
Ishida, N, Inuzuka, C, Tawaragi, Y, Sugita, O, Nakazato, H, Noguchi, T, ...
Tanaka, S, Oshima, T, Ohsue, K, Ono, T, Oikawa, S, Takano, I, ...
Chemically synthesized alpha-neo-endorphin gene was fused to the Escherichia coli beta-galactosidase gene on the plasmid pKO13. The resulting recombinant DNA was used to transform E. coli cells....
Expression of chemically synthesized alpha-neo-endorphin gene fused to E. coli alkaline phosphatase.
Ohsuye, K, Nomura, M, Tanaka, S, Kubota, I, Nakazato, H, Shinagawa, H, ...
An alpha-neo-endorphin (alpha NE) gene, which we previously synthesized chemically and inserted into E. coli beta-galactosidase gene of pK013 plasmid, has been excised and fused to E. coli alkaline...
Expression in Escherichia coli of chemically synthesized gene for the human immune interferon.
Tanaka, S, Oshima, T, Ohsuye, K, Ono, T, Mizono, A, Ueno, A, ...
A 454 base pair fragment of double stranded DNA consisting of a gene for a human immune interferon (hIFN-gamma), initiation and termination signals plus appropriate restriction endonuclease sites,...
Noguchi, T, Metz, R, Chen, L, Mattéi, M G, Carrasco, D, Bravo, R
We have characterized a growth factor-inducible gene, erp, and demonstrated that it encodes a 367-amino-acid nontransmembrane tyrosine phosphatase protein with significant similarity to the vaccinia...
Dobrazanski, P, Noguchi, T, Kovary, K, Rizzo, C A, Lazo, P S, Bravo, R
We demonstrate that a member of the fos family, the fosB gene, gives rise to two transcripts by alternative splicing of exon 4, generating two proteins, FosB of 338 amino acids and a short form,...
Noguchi, T, Fukumoto, H, Mishina, Y, Obinata, M
Erythropoietin (epo) appears to play a significant role in influencing the proliferation and differentiation of erythroid progenitor (CFU-E) cells. To determine the mechanism of action of epo, the...
Shimonaka, H., Noguchi, T., Kawai, K., Hasegawa, I., Nozawa, Y., Ito, Y.
The rhamnose-containing polysaccharide-peptide compound derived from the cells of the pathogenic fungus Sporothrix schenckii has been shown to contain 87.1% carbohydrate and 12.5% peptide and to give...
Ishida, N, Fujita, H, Fukuda, Y, Noguchi, T, Doss, M, Kappas, A, ...
Cloning and expression of the defective genes for delta-aminolevulinate dehydratase (ALAD) from a patient with inherited ALAD deficiency porphyria (ADP) were carried out. Cloning of cDNAs for the...
Localization of the mcf.2 transforming sequence to the X chromosome.
Noguchi, T, Mattei, M G, Oberlè, I, Planche, J, Imbert, J, Pelassy, C, ...
A transforming sequence was identified using co-transfection of DNA from the human mammary carcinoma cell line MCF-7 and of a G418 resistance gene into NIH 3T3 cells, followed by tumor formation in...
Ohashi-Takeuchi, H, Yamada, N, Hosokawa, R, Noguchi, T
Matrix vesicles are membrane-invested vesicles that initiate mineralization in the extracellular matrix of calcifying tissues. The epiphyseal cartilages of young-rat rib bones were divided into the...
It is generally accepted that all of the allantoin-degrading enzymes (allantoinase, allantoicase, ureidoglycollate lyase and urease), used in purine degradation, were lost during mammalian evolution....
Nakajima, H, Noguchi, T, Hamaguchi, T, Tomita, K, Hanafusa, T, Kono, N, ...
Molecular cloning of the 5' part of mouse phosphofructokinase-M cDNA was performed. In the 46 cDNA clones isolated, there were two classes of 5' untranslated sequences. One had an EcoRI site within...
Sassa, S, Sugita, O, Ohnuma, N, Imajo, S, Okumura, T, Noguchi, T, ...
Treatment of cultured chick-embryo liver cells with polychlorinated biphenyls (PCB) results in decreased uroporphyrinogen decarboxylase activity and increased uroporphyrin accumulation. In the...
Ureidoglycollate lyase, a new metalloenzyme of peroxisomal urate degradation in marine fish liver.
Ureidoglycollate lyase (UGL, EC 4.3.2.3), which catalyses the degradation of S(-)-ureidoglycollate to urea and glyoxylate, was found in the peroxisomes of marine fish (sardine and mackerel) liver....
Alanine: glyoxylate aminotransferase (EC 2.6.1.44), which is involved in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates in Saccharomyces...
The distribution of alanine:2-oxoglutarate aminotransferase (EC 2.6.1.2) in spinach (Spinacia oleracea) leaf homogenates was examined by centrifugation in a sucrose density gradient. About 55% of the...
Glutamate:glyoxylate aminotransferase had been reported to be present exclusively in the peroxisomes of plant leaves and to participate in the glycollate pathway in leaf photorespiration (Tolbert...
Organ distribution of rat histidine-pyruvate aminotransferase isoenzymes.
Noguchi, T, Minatogawa, Y, Okuno, E, Kido, R
The organ distribution of rat histidine-pyruvate aminotransferase isoenzymes 1 and 2 was examined by using an isoelectric-focusing technique. Isoenzyme 1 (pI8.0) is present only in the liver and its...
After glucagon injection, rats showed virtually identical percentage increases in hepatic histidine-pyruvate aminotransferase and serine-pyruvate aminotransferase activities, both in the mitochondria...
Identity of rat kidney histidine-pyruvate aminotransferase with glutamine-oxo acid aminotransferase.
Histidine-pyruvate aminotransferase and glutamine-phenylpyruvate aminotransferase were purified from rat kidney by the same procedure. The ratio of the two activities remained constant during...
Characteristics of hepatic serine-pyruvate aminotransferase in different mammalian species.
Noguchi, T, Takada, Y, Kido, R
1. Serine-pyruvate aminotransferase was purified from mouse, rat, dog and cat liver. Each enzyme preparation was homogeneous as judged by polyacrylamide-disc-gel electrophoresis in the presence of...
Takeda, H, Matozaki, T, Takada, T, Noguchi, T, Yamao, T, Tsuda, M, ...
Receptors coupled to the inhibitory G protein Gi, such as that for lysophosphatidic acid (LPA), have been shown to activate MAP kinase through a RAS-dependent pathway. However, LPA (but not insulin)...
Noguchi, T, Matozaki, T, Inagaki, K, Tsuda, M, Fukunaga, K, Kitamura, Y, ...
Dok, a 62-kDa Ras GTPase-activating protein (rasGAP)-associated phosphotyrosyl protein, is thought to act as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. Cell...
Noguchi, T, Minatogawa, Y, Okuno, E, Nakatani, M, Morimoto, M
1. Kynurenine-2-oxoglutarate aminotransferase (isoenzyme 1) was purified to homogeneity from the liver, brain and small intestine of rats by the same procedure. The three enzyme preparations had...
Noguchi, T, Okuno, E, Minatogawa, Y, Kido, R
1. Histidine-pyruvate aminotransferase (isoenzyme 1) was purified to homogeneity from the mitochondrial and supernatant fractions of rat liver, as judged by polyacrylamide-gel electrophoresis and...
Subcellular distribution of pyruvate (glyoxylate) aminotransferases in rat liver.
Noguchi, T, Minatogawa, Y, Takada, Y, Okuno, E, Kido, R
The distribution of pyruvate (glyoxylate) aminotransferases in the particulate fraction of rat liver homogenates was examined by centrifugation in a sucrose density graident. Aminotransferase...
Characteristics of hepatic alanine-glyoxylate aminotransferase in different mammalian species.
Noguchi, T, Okuno, E, Takada, Y, Minatogawa, Y, Okai, K, Kido, R
Mitochondrial extracts of dog, cat, rat and mouse liver contain two forms of alanine-glyoxylate aminotransferase (EC 2.6.1.44): one, designated isoenzyme 1, has mol.wt. approx. 80 000 and...
Purification and properties of peroxisomal pyruvate (glyoxylate) aminotransferase from rat liver.
Pyruvate (glyoxylate) aminotransferase from rat liver peroxisomes was highly purified and characterized. The enzyme preparation has a mol.wt. of approx. 80,000 with two identical subunits, and...
Ito, Y, Uchijima, Y, Ariga, M, Seki, T, Takenaka, A, Hakuno, F, ...
The present studies were undertaken to determine whether the interaction between cAMP-dependent and insulin-dependent pathways in primary cultures of rat hepatocytes affects biological functions and...
Yamada, K, Tanaka, T, Noguchi, T
The L-II element (-149 to -126 bp) in the enhancer unit of the rat pyruvate kinase L (PKL) gene is required for cell-type-specific transcription and induction by carbohydrates. This element was found...
Tomita, T, Ishikawa, D, Noguchi, T, Katayama, E, Hashimoto, Y
Flammutoxin has been previously isolated as a cardiotoxic and cytolytic polypeptide of 22 or 32 kDa from the fruiting bodies of the edible mushroom Flammulina velutipes. In the present study, we...
Nutrient and hormonal regulation of pyruvate kinase gene expression.
Mammalian pyruvate kinase (PK), a key glycolytic enzyme, has two genes named PKL and PKM, which produce the L- and R-type isoenzymes by means of alternative promoters, and the M1-and M2-types by...
Tanaka, T, Inazu, T, Yamada, K, Myint, Z, Keng, V W, Inoue, Y, ...
We isolated two cDNA clones of rat Hex, a homeobox protein, studied its expression in rat liver and various cells, and characterized the protein. The levels of Hex mRNA were only slightly increased...
Hayashi, H, Noguchi, T, Tasumi, M, Atkinson, G H
The vibrational spectroscopy and population dynamics of excited singlet (2(1)Ag), excited triplet (3B u), and the ground (1Ag) electronic states of carotenoids in chromatophores of Chromatium vinosum...
Noguchi, T, Matozaki, T, Horita, K, Fujioka, Y, Kasuga, M
SH-PTP2 is a nontransmembrane human protein-tyrosine phosphatase that contains two Src homology 2 (SH2) domains and binds to insulin receptor substrate 1 (IRS-1) via these domains in response to...
The Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis.
Klahre, U, Noguchi, T, Fujioka, S, Takatsuto, S, Yokota, T, Nomura, T, ...
We have identified the function of the Arabidopsis DIMINUTO/DWARF1 (DIM/DWF1) gene by analyzing the dim mutant, a severe dwarf with greatly reduced fertility. Both the mutant phenotype and gene...
Choe, S, Noguchi, T, Fujioka, S, Takatsuto, S, Tissier, C P, Gregory, B D, ...
Lesions in brassinosteroid (BR) biosynthetic genes result in characteristic dwarf phenotypes in plants. Understanding the regulation of BR biosynthesis demands continued isolation and...
The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis.
Fujioka, S, Li, J, Choi, Y H, Seto, H, Takatsuto, S, Noguchi, T, ...
The Arabidopsis DEETIOLATED2 (DET2) gene has been cloned and shown to encode a protein that shares significant sequence identity with mammalian steroid 5 alpha-reductases. Loss of DET2 function...
Nishihara, T, Ueda, N, Amano, K, Ishihara, Y, Hayakawa, H, Kuroyanagi, T, ...
The mechanism of osteoclast-like cell formation induced by periodontopathic bacterium Actinobacillus actinomycetemcomitans Y4 (serotype b) capsular-polysaccharide-like polysaccharide (capsular-like...
Matsuura, M, Noguchi, T, Yamaguchi, D, Aida, T, Asayama, M, Takahashi, H, ...
The sre gene (ORF469) of the R4 phage encodes a protein similar to the resolvase-DNA invertase family proteins. Insertional gene disruption of sre prevented a lysogen from entering the lytic cycle,...
Presence of Tetrodotoxin and Tetrodotoxin-Producing Bacteria in Freshwater Sediments
Do, H. K., Hamasaki, K., Ohwada, K., Simidu, U., Noguchi, T., Shida, Y., ...
The occurrence of tetrodotoxin (TTX) in sediment from Lake Suwa, Japan, was confirmed by a tissue culture assay, high-performance liquid chromatography, and gas chromatography-mass spectrometry....
Pharmacokinetics of cefpiramide (SM-1652) in humans.
Nakagawa, K, Koyama, M, Matsui, H, Ikeda, C, Yano, K, Nakatsuru, N, ...
The pharmacokinetics of cefpiramide (SM-1652) were studied after the intravenous administration of single or multiple doses to 21 healthy volunteers. The cefpiramide concentration in plasma at time...
Marine bacteria which produce tetrodotoxin.
Simidu, U, Noguchi, T, Hwang, D F, Shida, Y, Hashimoto, K
A number of type strains of marine bacteria, including members of the family Vibrionaceae, were cultured and examined for tetrodotoxin productivity by high-performance liquid chromatography and gas...
Fujioka, Y, Matozaki, T, Noguchi, T, Iwamatsu, A, Yamao, T, Takahashi, N, ...
Protein tyrosine phosphatases (PTPases), such as SHP-1 and SHP-2, that contain Src homology 2 (SH2) domains play important roles in growth factor and cytokine signal transduction pathways. A protein...
Amano, K, Nishihara, T, Shibuya, N, Noguchi, T, Koga, T
A serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b) was extracted from whole cells by autoclaving. The extract was purified by chromatography on...
Koga, T, Nishihara, T, Fujiwara, T, Nisizawa, T, Okahashi, N, Noguchi, T, ...
Lipopolysaccharides (LPSs) were isolated from Bacteroides gingivalis and Escherichia coli by the phenol-water and butanol-water procedures. The phenol-water-extracted LPS from B. gingivalis 381 was...
Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter.
Lazo, P S, Dorfman, K, Noguchi, T, Mattéi, M G, Bravo, R
We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene. By deletion analysis we have characterized a...
Cytochrome P450CMF cDNA: nucleotide sequence of P450CMF1b.
Ishida, N, Inuzuka, C, Tawaragi, Y, Sugita, O, Nakazato, H, Noguchi, T, ...
Tanaka, S, Oshima, T, Ohsue, K, Ono, T, Oikawa, S, Takano, I, ...
Chemically synthesized alpha-neo-endorphin gene was fused to the Escherichia coli beta-galactosidase gene on the plasmid pKO13. The resulting recombinant DNA was used to transform E. coli cells....
Expression of chemically synthesized alpha-neo-endorphin gene fused to E. coli alkaline phosphatase.
Ohsuye, K, Nomura, M, Tanaka, S, Kubota, I, Nakazato, H, Shinagawa, H, ...
An alpha-neo-endorphin (alpha NE) gene, which we previously synthesized chemically and inserted into E. coli beta-galactosidase gene of pK013 plasmid, has been excised and fused to E. coli alkaline...
Expression in Escherichia coli of chemically synthesized gene for the human immune interferon.
Tanaka, S, Oshima, T, Ohsuye, K, Ono, T, Mizono, A, Ueno, A, ...
A 454 base pair fragment of double stranded DNA consisting of a gene for a human immune interferon (hIFN-gamma), initiation and termination signals plus appropriate restriction endonuclease sites,...
Noguchi, T, Matozaki, T, Horita, K, Fujioka, Y, Kasuga, M
SH-PTP2 is a nontransmembrane human protein-tyrosine phosphatase that contains two Src homology 2 (SH2) domains and binds to insulin receptor substrate 1 (IRS-1) via these domains in response to...
Noguchi, T, Metz, R, Chen, L, Mattéi, M G, Carrasco, D, Bravo, R
We have characterized a growth factor-inducible gene, erp, and demonstrated that it encodes a 367-amino-acid nontransmembrane tyrosine phosphatase protein with significant similarity to the vaccinia...
Dobrazanski, P, Noguchi, T, Kovary, K, Rizzo, C A, Lazo, P S, Bravo, R
We demonstrate that a member of the fos family, the fosB gene, gives rise to two transcripts by alternative splicing of exon 4, generating two proteins, FosB of 338 amino acids and a short form,...
Noguchi, T, Fukumoto, H, Mishina, Y, Obinata, M
Erythropoietin (epo) appears to play a significant role in influencing the proliferation and differentiation of erythroid progenitor (CFU-E) cells. To determine the mechanism of action of epo, the...
Shimonaka, H., Noguchi, T., Kawai, K., Hasegawa, I., Nozawa, Y., Ito, Y.
The rhamnose-containing polysaccharide-peptide compound derived from the cells of the pathogenic fungus Sporothrix schenckii has been shown to contain 87.1% carbohydrate and 12.5% peptide and to give...
Ishida, N, Fujita, H, Fukuda, Y, Noguchi, T, Doss, M, Kappas, A, ...
Cloning and expression of the defective genes for delta-aminolevulinate dehydratase (ALAD) from a patient with inherited ALAD deficiency porphyria (ADP) were carried out. Cloning of cDNAs for the...
Localization of the mcf.2 transforming sequence to the X chromosome.
Noguchi, T, Mattei, M G, Oberlè, I, Planche, J, Imbert, J, Pelassy, C, ...
A transforming sequence was identified using co-transfection of DNA from the human mammary carcinoma cell line MCF-7 and of a G418 resistance gene into NIH 3T3 cells, followed by tumor formation in...
Ohashi-Takeuchi, H, Yamada, N, Hosokawa, R, Noguchi, T
Matrix vesicles are membrane-invested vesicles that initiate mineralization in the extracellular matrix of calcifying tissues. The epiphyseal cartilages of young-rat rib bones were divided into the...
It is generally accepted that all of the allantoin-degrading enzymes (allantoinase, allantoicase, ureidoglycollate lyase and urease), used in purine degradation, were lost during mammalian evolution....
Nakajima, H, Noguchi, T, Hamaguchi, T, Tomita, K, Hanafusa, T, Kono, N, ...
Molecular cloning of the 5' part of mouse phosphofructokinase-M cDNA was performed. In the 46 cDNA clones isolated, there were two classes of 5' untranslated sequences. One had an EcoRI site within...
Sassa, S, Sugita, O, Ohnuma, N, Imajo, S, Okumura, T, Noguchi, T, ...
Treatment of cultured chick-embryo liver cells with polychlorinated biphenyls (PCB) results in decreased uroporphyrinogen decarboxylase activity and increased uroporphyrin accumulation. In the...
Ureidoglycollate lyase, a new metalloenzyme of peroxisomal urate degradation in marine fish liver.
Ureidoglycollate lyase (UGL, EC 4.3.2.3), which catalyses the degradation of S(-)-ureidoglycollate to urea and glyoxylate, was found in the peroxisomes of marine fish (sardine and mackerel) liver....
Alanine: glyoxylate aminotransferase (EC 2.6.1.44), which is involved in the glyoxylate pathway of glycine and serine biosynthesis from tricarboxylic acid-cycle intermediates in Saccharomyces...
The distribution of alanine:2-oxoglutarate aminotransferase (EC 2.6.1.2) in spinach (Spinacia oleracea) leaf homogenates was examined by centrifugation in a sucrose density gradient. About 55% of the...
Glutamate:glyoxylate aminotransferase had been reported to be present exclusively in the peroxisomes of plant leaves and to participate in the glycollate pathway in leaf photorespiration (Tolbert...
Organ distribution of rat histidine-pyruvate aminotransferase isoenzymes.
Noguchi, T, Minatogawa, Y, Okuno, E, Kido, R
The organ distribution of rat histidine-pyruvate aminotransferase isoenzymes 1 and 2 was examined by using an isoelectric-focusing technique. Isoenzyme 1 (pI8.0) is present only in the liver and its...
After glucagon injection, rats showed virtually identical percentage increases in hepatic histidine-pyruvate aminotransferase and serine-pyruvate aminotransferase activities, both in the mitochondria...
Identity of rat kidney histidine-pyruvate aminotransferase with glutamine-oxo acid aminotransferase.
Histidine-pyruvate aminotransferase and glutamine-phenylpyruvate aminotransferase were purified from rat kidney by the same procedure. The ratio of the two activities remained constant during...
Characteristics of hepatic serine-pyruvate aminotransferase in different mammalian species.
Noguchi, T, Takada, Y, Kido, R
1. Serine-pyruvate aminotransferase was purified from mouse, rat, dog and cat liver. Each enzyme preparation was homogeneous as judged by polyacrylamide-disc-gel electrophoresis in the presence of...
Takeda, H, Matozaki, T, Takada, T, Noguchi, T, Yamao, T, Tsuda, M, ...
Receptors coupled to the inhibitory G protein Gi, such as that for lysophosphatidic acid (LPA), have been shown to activate MAP kinase through a RAS-dependent pathway. However, LPA (but not insulin)...
Noguchi, T, Matozaki, T, Inagaki, K, Tsuda, M, Fukunaga, K, Kitamura, Y, ...
Dok, a 62-kDa Ras GTPase-activating protein (rasGAP)-associated phosphotyrosyl protein, is thought to act as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. Cell...
Noguchi, T, Minatogawa, Y, Okuno, E, Nakatani, M, Morimoto, M
1. Kynurenine-2-oxoglutarate aminotransferase (isoenzyme 1) was purified to homogeneity from the liver, brain and small intestine of rats by the same procedure. The three enzyme preparations had...
Noguchi, T, Okuno, E, Minatogawa, Y, Kido, R
1. Histidine-pyruvate aminotransferase (isoenzyme 1) was purified to homogeneity from the mitochondrial and supernatant fractions of rat liver, as judged by polyacrylamide-gel electrophoresis and...
Subcellular distribution of pyruvate (glyoxylate) aminotransferases in rat liver.
Noguchi, T, Minatogawa, Y, Takada, Y, Okuno, E, Kido, R
The distribution of pyruvate (glyoxylate) aminotransferases in the particulate fraction of rat liver homogenates was examined by centrifugation in a sucrose density graident. Aminotransferase...
Characteristics of hepatic alanine-glyoxylate aminotransferase in different mammalian species.
Noguchi, T, Okuno, E, Takada, Y, Minatogawa, Y, Okai, K, Kido, R
Mitochondrial extracts of dog, cat, rat and mouse liver contain two forms of alanine-glyoxylate aminotransferase (EC 2.6.1.44): one, designated isoenzyme 1, has mol.wt. approx. 80 000 and...
Purification and properties of peroxisomal pyruvate (glyoxylate) aminotransferase from rat liver.
Pyruvate (glyoxylate) aminotransferase from rat liver peroxisomes was highly purified and characterized. The enzyme preparation has a mol.wt. of approx. 80,000 with two identical subunits, and...
Ito, Y, Uchijima, Y, Ariga, M, Seki, T, Takenaka, A, Hakuno, F, ...
The present studies were undertaken to determine whether the interaction between cAMP-dependent and insulin-dependent pathways in primary cultures of rat hepatocytes affects biological functions and...
Yamada, K, Tanaka, T, Noguchi, T
The L-II element (-149 to -126 bp) in the enhancer unit of the rat pyruvate kinase L (PKL) gene is required for cell-type-specific transcription and induction by carbohydrates. This element was found...
Tomita, T, Ishikawa, D, Noguchi, T, Katayama, E, Hashimoto, Y
Flammutoxin has been previously isolated as a cardiotoxic and cytolytic polypeptide of 22 or 32 kDa from the fruiting bodies of the edible mushroom Flammulina velutipes. In the present study, we...
Nutrient and hormonal regulation of pyruvate kinase gene expression.
Mammalian pyruvate kinase (PK), a key glycolytic enzyme, has two genes named PKL and PKM, which produce the L- and R-type isoenzymes by means of alternative promoters, and the M1-and M2-types by...
Tanaka, T, Inazu, T, Yamada, K, Myint, Z, Keng, V W, Inoue, Y, ...
We isolated two cDNA clones of rat Hex, a homeobox protein, studied its expression in rat liver and various cells, and characterized the protein. The levels of Hex mRNA were only slightly increased...
Hayashi, H, Noguchi, T, Tasumi, M, Atkinson, G H
The vibrational spectroscopy and population dynamics of excited singlet (2(1)Ag), excited triplet (3B u), and the ground (1Ag) electronic states of carotenoids in chromatophores of Chromatium vinosum...
Yanai, H, Noguchi, T, Mizumachi, S, Tokiyama, H, Nakamura, H, Tada, M, ...
a First Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan, b Department of Gastroenterology, Kokura Memorial Hospital, Kitakyusyu, Japan, c Department of...
Iwata, T, Mitani, A, Ishihara, Y, Tanaka, S, Yamamoto, G, Kikuchi, T, ...
Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) induces bone resorption in a mouse organ culture system and osteoclast formation in mouse bone marrow cultures, as...
Into, T, Inomata, M, Kanno, Y, Matsuyama, T, Machigashira, M, Izumi, Y, ...
Chronic periodontitis is correlated with Porphyromonas gingivalis infection. In this study, we found that the expression of secretory leucocyte protease inhibitor (SLPI), an endogenous inhibitor for...
Noguchi, T, Homma, S, Nakajima, Y
The patellar tendon was tapped by random impulses of triangular waveform and motor unit spikes were recorded from the quadriceps femoris muscle. The cross-correlogram of the taps and the motor unit...
MITANI, A, NISHIMURA, H, HIROSE, K, WASHIZU, J, KIMURA, Y, TANAKA, S, ...
We previously reported that exogenous interleukin-15 (IL-15) induces proliferation and activation of intestinal intraepithelial lymphocytes (i-IEL) in naive mice. To investigate the ability of...
Imamura, S., Kobayashi, J., Nakajima, K., Sakasegawa, S., Nohara, A., Noguchi, T., ...
The objective of this study was to establish a new lipoprotein lipase (LPL) and hepatic lipase (HL) activity assay method. Seventy normal volunteers were recruited. Lipase activities were assayed by...
Ryu, H, Walker, J K L, Kim, S, Koo, N, Barak, L S, Noguchi, T, ...
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma
Kikuchi, R, Noguchi, T, Takeno, S, Kubo, N, Uchida, Y
We investigated whether the expression of membrane-type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) was consistent...
Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas
Kikuchi, R, Noguchi, T, Takeno, S, Funada, Y, Moriyama, H, Uchida, Y
BAG-1 is a recently identified Bcl-2-interacting anti-apoptotic protein. The aim of our study was to investigate the immunohistochemical staining pattern of BAG-1 protein in patients with colorectal...