Fleckenstein, Johannes, Kramer, Sybille, Hoffrogge, Philipp, Thoma, Sarah, Lang, Philip M, Lehmeyer, Lukas, ...
Abstract Background Acute herpes zoster is a prevalent condition. One of its major symptoms is pain, which can highly influence patient's quality of life. Pain therapy is limited. Acupuncture is...
Henschel, Volkmar, Engel, Jutta, Hölzel, Dieter, Mansmann, Ulrich
Abstract Background Multivariate analysis of interval censored event data based on classical likelihood methods is notoriously cumbersome. Likelihood inference for models which additionally include...
State-of-the-Art in Parallel Computing with R (2009)
Schmidberger, Markus, Morgan, Martin, Eddelbuettel, Dirk, Yu, Hao, Tierney, Luke, Mansmann, Ulrich
R is a mature open-source programming language for statistical computing and graphics. Many areas of statistical research are experiencing rapid growth in the size of data sets. Methodological...
Markus Schmidberger, Esmeralda Vicedo, Ulrich Mansmann
Microarray data repositories as well as large clinical applications of gene expression allow to analyse several hundreds of microarrays at one time. The preprocessing of large amounts of microarrays...
State of the Art in Parallel Computing with R (2009)
Markus Schmidberger, Martin Morgan, Dirk Eddelbuettel, Hao Yu, Luke Tierney, Ulrich Mansmann
R is a mature open-source programming language for statistical computing and graphics. Many areas of statistical research are experiencing rapid growth in the size of data sets. Methodological...
Volkmar Henschel, Jutta Engel, Dieter Hoelzel, Ulrich Mansmann, Volkmar Henschel, Jutta Engel, ...
This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. A semiparametric Bayesian proportional...
De Allegri, Manuela, Pokhrel, Subhash, Becher, Heiko, Dong, Hengjin, Mansmann, Ulrich, Kouyaté, Bocar, ...
Abstract Background We describe a step-wedge cluster-randomised community-based trial which has been conducted since 2003 to accompany the implementation of a community health insurance (CHI) scheme...
Alternative regression models to assess increase in childhood BMI (2008)
Beyerlein, Andreas, Fahrmeir, Ludwig, Mansmann, Ulrich, Toschke, André M
Abstract Background Body mass index (BMI) data usually have skewed distributions, for which common statistical modeling approaches such as simple linear or logistic regression have limitations....
Reproducible statistical analysis in microarray profiling studies (2008)
Reproducibility of calculations is a longstanding issue within the statistical community (Leisch and Rossini, 2003). Due to the complexity of the algorithms, the size of the data sets, and the...
Association Between a Prognostic Gene Signature and Functional Gene Sets (2008)
Manuela Hummel, Klaus H. Metzeler, Christian Buske, Stefan K. Bohlander, Ulrich Mansmann
Background: The development of expression-based gene signatures for predicting prognosis or class membership is a popular and challenging task. Besides their stringent validation, signatures need a...
Multiple testing on the directed acyclic graph of gene ontology (2008)
Goeman, Jelle J., Mansmann, Ulrich
Motivation: Current methods for multiplicity adjustment do not make use of the graph structure of Gene Ontology (GO) when testing for association of expression profiles of GO terms with a response...
GlobalANCOVA: exploration and assessment of gene group effects (2008)
Hummel, Manuela, Meister, Reinhard, Mansmann, Ulrich
Motivation: Several authors have studied expression in gene sets with specific goals: overrepresentation of interesting genes in functional groups, predictive power for class membership and searches...
Meissner, Peter E, Mandi, Germain, Coulibaly, Boubacar, Witte, Steffen, Tapsoba, Théophile, Mansmann, Ulrich, ...
Abstract The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine...
Köninger, Jörg, Seiler, Christoph M, Wente, Moritz N, Reidel, Margot A, Gazyakan, Emre, Mansmann, Ulrich, ...
Abstract Background Chronic pancreatitis is an inflammatory disease which is characterized by an irreversible conversion of pancreatic parenchyma to fibrous tissue. Beside obstructive jaundice and...
Groene, Joern, Mansmann, Ulrich, Meister, Reinhard, Staub, Eike, Roepcke, Stefan, Heinze, Maya, ...
UICC stage II and III colorectal cancers (CRC) differ fundamentally in prognosis and therapeutic concepts. To analyze differential gene expression between both stages and to establish a relationship...
Meissner, Peter E, Mandi, Germain, Witte, Steffen, Coulibaly, Boubacar, Mansmann, Ulrich, Rengelshausen, Jens, ...
Abstract Background Safe, effective and affordable drug combinations against falciparum malaria are urgently needed for the poor populations in malaria endemic countries. Methylene blue (MB) combined...
A Compendium to Ensure Computational Reproducibility in High-Dimensional Classification Tasks (2004)
Ruschhaupt, Markus, Huber, Wolfgang, Poustka, Annemarie, Mansmann, Ulrich
We demonstrate a concept and implementation of a compendium for the classification of high-dimensional data from microarray gene expression profiles. A compendium is an interactive document that...
A Compendium to Ensure Computational Reproducibility in High-Dimensional Classification Tasks (2004)
Ruschhaupt, Markus, Huber, Wolfgang, Poustka, Annemarie, Mansmann, Ulrich
We demonstrate a concept and implementation of a compendium for the classification of high-dimensional data from microarray gene expression profiles. A compendium is an interactive document that...
A Compendium to Ensure Computational Reproducibility in High-Dimensional Classification Tasks (2004)
Ruschhaupt, Markus, Huber, Wolfgang, Poustka, Annemarie, Mansmann, Ulrich
We demonstrate a concept and implementation of a compendium for the classification of high-dimensional data from microarray gene expression profiles. A compendium is an interactive document that...
A Compendium to Ensure Computational Reproducibility in High-Dimensional Classification Tasks (2004)
Ruschhaupt, Markus, Huber, Wolfgang, Poustka, Annemarie, Mansmann, Ulrich
We demonstrate a concept and implementation of a compendium for the classification of high-dimensional data from microarray gene expression profiles. A compendium is an interactive document that...
Streitberger, Konrad, Witte, Steffen, Mansmann, Ulrich, Knauer, Christine, Krämer, Jürgen, Scharf, Hanns-Peter, ...
Abstract Background Controlled clinical trials produced contradictory results with respect to a specific analgesic effect of acupuncture. There is a lack of large multi-centre acupuncture trials. The...
Ammenwerth, Elske, Eichstädter, Ronald, Hoppe, Bettina, Mahler, Cornelia, Mansmann, Ulrich, Tautz Angelika, ...
Die Umstellung der konventionellen Pflegeprozessdokumentation auf ein rechnerbasiertes Pflegedokumentationssystem ist ein wichtiges Thema am Universitätsklinikum Heidelberg. Daher werden seit 1998...
Wilhelm, Daniel, Mansmann, Ulrich, Neudeck, Hermann, Matejevic, Dragan, Vetter, Klaus, Graf, Renate
In a recent study we described an increase of elastic tissue fibres in blood vessel walls of placental stem villi during pre-eclampsia when compared to uncomplicated pregnancies. Furthermore, the...
Practical microarray analysis – resampling and the bootstrap (2002)
Ulrich Mansmann, Gg Σk, Vgkg Σg Vgkg
Practical microarray analysis – resampling and the bootstrap
Mahler, Cornelia, Ammenwerth, Elske, Eichstädter, Ronald, Hoppe, Bettina, Mansmann, Ulrich, Tautz Angelika, ...
Die Umstellung der konventionellen Pflegeprozessdokumentation auf ein rechnerbasiertes Pflegedokumentationssystem ist ein wichtiges Thema am Universitätsklinikum Heidelberg. Daher werden seit 1998...
Ammenwerth, Elske, Eichstädter, Ronald, Happek, Torsten, Haux, Reinhold, Hoppe, Bettina, Kandert, Marianne, ...
Seit Jahren besteht der Wunsch, die Pflegedokumentation durch EDV-Einsatz zu unterstützen, um die Qualität der Dokumentation zu erhöhen, Aufwände für die Pflegekräfte zu reduzieren,...
Ammenwerth, Elske, Eichstädter, Ronald, Happek, Torsten, Haux, Reinhold, Hoppe, Bettina, Kandert, Marianne, ...
Seit Jahren besteht der Wunsch, die Pflegedokumentation durch EDV-Einsatz zu unterstützen, um die Qualität der Dokumentation zu erhöhen, Aufwände für die Pflegekräfte zu reduzieren,...
Ammenwerth, Elske, Mansmann, Ulrich, Iller, Carola, Eichstädter, Ronald
Objectives: The documentation of the nursing process is an important but often neglected part of clinical documentation. Paper-based systems have been introduced to support nursing process...
Streitberger, Konrad, Witte, Steffen, Mansmann, Ulrich, Knauer, Christine, Krämer, Jürgen, Scharf, Hanns-Peter, ...
Meissner, Peter E, Mandi, Germain, Witte, Steffen, Coulibaly, Boubacar, Mansmann, Ulrich, Rengelshausen, Jens, ...
Köninger, Jörg, Seiler, Christoph M, Wente, Moritz N, Reidel, Margot A, Gazayakan, Emre, Mansmann, Ulrich, ...
Meissner, Peter E, Mandi, Germain, Coulibaly, Boubacar, Witte, Steffen, Tapsoba, Théophile, Mansmann, Ulrich, ...
The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has...
Ammenwerth, Elske, Mansmann, Ulrich, Iller, Carola, Eichstädter, Ronald
Objectives: The documentation of the nursing process is an important but often neglected part of clinical documentation. Paper-based systems have been introduced to support nursing process...
Streitberger, Konrad, Witte, Steffen, Mansmann, Ulrich, Knauer, Christine, Krämer, Jürgen, Scharf, Hanns-Peter, ...
Meissner, Peter E, Mandi, Germain, Witte, Steffen, Coulibaly, Boubacar, Mansmann, Ulrich, Rengelshausen, Jens, ...
Köninger, Jörg, Seiler, Christoph M, Wente, Moritz N, Reidel, Margot A, Gazayakan, Emre, Mansmann, Ulrich, ...
Meissner, Peter E, Mandi, Germain, Coulibaly, Boubacar, Witte, Steffen, Tapsoba, Théophile, Mansmann, Ulrich, ...
The development of safe, effective and affordable drug combinations against malaria in Africa is a public health priority. Methylene blue (MB) has a similar mode of action as chloroquine (CQ) and has...
Fricker, Ruth, Hesse, Christiane, Weiss, Johanna, Tayrouz, Yorki, Hoffmann, Michael M, Unnebrink, Kristina, ...
Zoungrana, Augustin, Coulibaly, Boubacar, Sié, Ali, Walter-Sack, Ingeborg, Mockenhaupt, Frank P., Kouyaté, Bocar, ...
A Compendium to Ensure Computational Reproducibility in High-Dimensional Classification Tasks
Markus Ruschhaupt, Wolfgang Huber, Annemarie Poustka, Ulrich Mansmann
We demonstrate a concept and implementation of a compendium for the classification of high-dimensional data from microarray gene expression profiles. A compendium is an interactive document that...
Alternative regression models to assess increase in childhood BMI
Beyerlein, Andreas, Fahrmeir, Ludwig, Mansmann, Ulrich, Toschke, André M
De Allegri, Manuela, Pokhrel, Subhash, Becher, Heiko, Dong, Hengjin, Mansmann, Ulrich, Kouyaté, Bocar, ...
Coulibaly, Boubacar, Zoungrana, Augustin, Mockenhaupt, Frank P., Schirmer, R. Heiner, Klose, Christina, Mansmann, Ulrich, ...
A semiparametric Bayesian proportional hazards model for interval censored data with frailty effects
Henschel, Volkmar, Engel, Jutta, Hölzel, Dieter, Mansmann, Ulrich
Epidemiology and Quality Control of 245 000 Outpatient Colonoscopies
Mansmann, Ulrich, Crispin, Alexander, Henschel, Volkmar, Adrion, Christine, Augustin, Volker, Birkner, Berndt, ...
Fleckenstein, Johannes, Kramer, Sybille, Hoffrogge, Philipp, Thoma, Sarah, Lang, Philip M, Lehmeyer, Lukas, ...
Association Between a Prognostic Gene Signature and Functional Gene Sets
Hummel, Manuela, Metzeler, Klaus H., Buske, Christian, Bohlander, Stefan K., Mansmann, Ulrich
Scholl, Hendrik P. N., Fleckenstein, Monika, Fritsche, Lars G., Schmitz-Valckenberg, Steffen, Göbel, Arno, Adrion, Christine, ...
State of the Art in Parallel Computing with R
R is a mature open-source programming language for statistical computing and graphics. Many areas of statistical research are experiencing rapid growth in the size of data sets. Methodological...