Therapeutic use of surfactant components in allergic asthma (2009)
Erpenbeck, V.J., Krug, N., Hohlfeld, J.M.
Pulmonary surfactant is a complex mixture of lipids and proteins that reduces the surface tension at the air-liquid interface. In addition to its biophysical function, some surfactant components play...
Erpenbeck, V.J., Fischer, I., Wiese, K., Schaumann, F., Schmiedl, A., Nassenstein, C., ...
Background: There is increasing interest in testing surfactant preparations for asthma therapy. Previously, Curosurf was demonstrated to increase inflammation in allergic asthmatics. So far, little...
Schleh, C., Muhlfeld, C., Pulskamp, K., Schmiedl, S., Nassimi, M., Lauenstein, H.D., ...
Background Pulmonary surfactant reduces surface tension and is present at the air-liquid interface in the alveoli where inhaled nanoparticles preferentially deposit. We investigated the effect of...
Schleh, C., Muhlfeld, C., Pulskamp, K., Schmiedl, S., Nassimi, M., Lauenstein, H.D., ...
Background Pulmonary surfactant reduces surface tension and is present at the air-liquid interface in the alveoli where inhaled nanoparticles preferentially deposit. We investigated the effect of...
Die Interaktion zwischen pulmonalem Surfactant und inhalierbaren Partikeln (2009)
Pulmonary surfactant covers the alveoli and reduces surface tension at the air liquid interface, thus maintaining lung function and preventing alveolar collapse. Furthermore, specific surfactant...
Effect of nanosized particles on pulmonary surfactant function (2007)
Schleh, C., Krug, N., Erpenbeck, V.J., Hohlfeld, J.M.
After inhalation, nanoparticles reach the deeper airways and get into contact with the pulmonary surfactant layer, whose main function is to lower surface tension in the alveoli. The aim of our study...
Erpenbeck, V.J., Schmidt, R., Gunther, A., Krug, N., Hohlfeld, J.M.
Background: Allergic asthma is associated with airway inflammation and dysfunction of pulmonary surfactant. Because surfactant proteins (SP) account for immunomodulatory functions as well as...
Lung fibroblasts from patients with emphysema show markers of senescence in vitro (2006)
Müller, K.C., Welker, L., Paasch, K., Feindt, B., Erpenbeck, V.J., Hohlfeld, J.M., ...
Background: The loss of alveolar walls is a hallmark of emphysema. As fibroblasts play an important role in the maintenance of alveolar structure, a change in fibroblast phenotype could be involved...
Surfactant protein D inhibits early airway response in Aspergillus fumigatus-sensitized mice (2006)
Erpenbeck, V.J., Ziegert, M., Cavalet-Blanco, D., Martin, C., Bälder, R., Glaab, T., ...
BACKGROUND: The surfactant protein SP-D has been reported to reduce bronchial hyper-responsiveness, blood eosinophilia, and T-helper type 2 cytokines in models of allergic asthma. However, little is...
Thum, T., Erpenbeck, V.J., Moeller, J., Hohlfeld, J.M., Krug, N., Borlak, J.
Background. Cytochrome P450 monooxygenases (CYP) play an important role in the defense against inhaled toxicants and expression of CYP enzymes may differ amongst various lung cells and tissue...
Nassenstein, C., Dawbarn, D., Pollock, K., Allen, S.J., Erpenbeck, V.J., Spies, E., ...
Background Neurotrophins have been implicated in the pathogenesis of asthma because of their ability to promote hyperreactivity of sensory neurons and to induce airway inflammation. Hyperreactivity...
Erpenbeck, V.J., Hagenberg, A., Krentel, H., Discher, M., Braun, A., Hohlfeld, J.M., ...
BACKGROUND: GATA-3 (GATA binding protein 3) and the proto-oncogene c-maf are Th2-regulating transcription factors that control the expression of interleukin (IL)-4 and IL-5, while T-bet (T-box...
Erpenbeck, V.J., Malherbe, D.C., Sommer, S., Schmiedl, A., Steinhilber, W., Ghio, A.J., ...
Recent studies have shown that surfactant components, in particular the collectins surfactant protein (SP)-A and -D, modulate the phagocytosis of various pathogens by alveolar macrophages. This...
Erpenbeck, V.J., Jörres, R.A., Discher, M., Luettig, B., Krug, N., Hohlfeld, J.M.
Nitric oxide (NO) levels are increased in the exhaled air of asthmatics. As NO levels correlate with allergic airway inflammation, NO measurement has been suggested for disease monitoring. In...
Doganci, A., Eigenbrod, T., Krug, N., Sanctis, G.T. De, Hausding, M., Erpenbeck, V.J., ...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound IL-6 receptor (mIL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). In this study, we...
Gebhardt, T., Gerhard, R., Bedoui, S., Erpenbeck, V.J., Hoffmann, M.W., Manns, M.P., ...
Previous studies indicated potent inhibitory effects of 2-adrenoceptor (2AR) activation on the immunological mediator release of mast cells (MC). Here, we studied effects of 2AR agonists on human MC...
Erpenbeck, V.J., Hagenberg, A., Dulkys, Y., Elsner, J., Balder, R., Krentel, H., ...
There is increasing evidence for a role of pulmonary surfactant in asthma and allergic inflammation. In murine asthma models, recent studies have demonstrated that surfactant components downregulate...
Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma (2004)
Hohlfeld, J.M., Schmiedl, A., Erpenbeck, V.J., Venge, P., Krug, N.
BACKGROUND: Impaired surfactant function has been demonstrated in patients with asthma. Inhibitory proteins originating from plasma or inflammatory mediators are good candidates to contribute to this...
Local release of eosinophil peroxidase following segmental allergen provocation in asthma (2003)
Erpenbeck, V.J., Hohlfeld, J.M., Petschallies, J., Eklund, E., Peterson, C.G.B., Fabel, H., ...
Background Eosinophil peroxidase (EPO) is an eosinophilic basic protein, which leads to increased permeability and damage of bronchial epithelial cells in asthma. Objective As little is known about...
Tsikas, D., Schwedhelm, E., Niemann, J., Erpenbeck, V.J., ...
Free radical-catalysed oxidation of arachidonic acid esterified to lipids leads to the formation of the F2-isoprostane family which may theoretically comprise up to 64 isomers. We have previously...
Nassenstein, C., Braun, A., Erpenbeck, V.J., Lommatzsch, M., Schmidt, S., Krug, N., ...
Neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin [NT]-3, and NT-4) have been observed in elevated concentrations in allergic diseases. Neurotrophin...
Erpenbeck, V.J., Hohlfeld, J.M., Volkmann, B., Hagenberg, A., Geldmacher, H., Braun, A., ...
BACKGROUND: IL-9 is a T(H)2 cell-derived cytokine that might be involved in the pathophysiology of allergic diseases. Little is known about its expression and release during the allergic response in...
Surfactant proteins SP-A and SP-D as modulators of the allergic inflammation in asthma (2003)
Hohlfeld, J.M., Erpenbeck, V.J., Krug, N.
Surfactant proteins A and D (SP-A and SP-D) are members of the collectin family and bind to various motifs of microorganisms, particles and allergens. They play an important role in the first-line...
Krug, N., Erpenbeck, V.J., Balke, K., Petschallies, J., Tschernig, T., Hohlfeld, J.M., ...
T cell-derived cytokines play an important role in the pathogenesis of allergic asthma, but little is known about the cytokine profile of their different subsets. The aim of the present study was to...
Krug, N., Tschernig, T., Erpenbeck, V.J., Hohlfeld, J.M., Köhl, J.
Allergic asthma Is thought to be the result of an inappropriate specific immune response against common environmental antigens. However, studies of animal asthma models have also linked the innate...
Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge (1999)
Hohlfeld, J.M., Ahlf, K., Enhorning, G., Balke, K., Erpenbeck, V.J., Petschallies, J., ...
Increased airway resistance in asthma may be partly due to poor function of pulmonary surfactant. This study investigated the inflammatory changes of bronchoalveolar lavage fluid (BALF) and the...
Hohlfeld, J.M., Ahlf, K., Balke, K., Erpenbeck, V.J., Petschallies, J., Hoymann, H.G., ...
Surfactant ist nicht nur für die Stabilisierung der Alviolen wichtig, sondern scheint auch eine Bedeutung in den Atemwegen zu haben. Die Atemwegsobstruktion beim Asthma könnte daher teilweise auf...
Pulmonary surfactant function is impaired in asthmatics after segmental allergen challenge (1998)
Hohlfeld, J.M., Ahlf, K., Erpenbeck, V.J., Petschallies, J., Hoymann, H.G., Krug, N., ...
Airway obstruction in asthma may in part be due to surfactant dysfunction. The purpose of this study was to investigate surfactant function and composition in brochoalveolar lavage (BAL) fluids of...