Ngoyi, D. M., Lejon, V., N'Siesi, F. X., Boelaert, M., Büscher, P.
OBJECTIVE: To develop a simple and standard operational decision tool for the diagnosis of relapse after treatment for human African trypanosomiasis (HAT), by evaluating the performance of several...
Hainard, A., Tiberti, N., Robin, X., Lejon, V., Ngoyi, D. M., Matovu, E., ...
BACKGROUND: Human African trypanosomiasis (HAT), also known as sleeping sickness, is a parasitic tropical disease. It progresses from the first, haemolymphatic stage to a neurological second stage...
Lejon, V., Roger, I., Ngoyi, D. M., Robays, J., N'Siesi, X., Bisser, S., ...
BACKGROUND: To date, no biological marker for treatment outcome in human African trypanosomiasis (HAT) has been described. The accuracy of biological markers for prediction of treatment outcome of...
Bisser, S., N'Siesi, F. X., Lejon, V., Preux, P. M., Van Nieuwenhove, S., ...
BACKGROUND: Treatment of second-stage sleeping sickness relies mainly on melarsoprol. Nifurtimox has been successfully used to cure melarsoprol-refractory sleeping sickness caused by Trypanosoma...
Lejon, V., Robays, J., N'Siesi, F. X., Mumba, D., Hoogstoel, A., Bisser, S., ...
Human African trypanosomiasis treatment is stage dependent, but the tests used for staging are controversial. Central nervous system involvement and its relationship with suramin treatment failure...
Koffi, M., Solano, P., Denizot, M., Courtin, D., Garcia, A., Lejon, V., ...
The serological and parasitological tests used for Trypanosoma brucei gambiense human African trypanosomiasis (HAT) diagnosis have low specificity and sensitivity, respectively, and in the field,...
Lejon, V., Jamonneau, V., Solano, P., Atchade, P., Mumba, D., Nkoy, N., ...
The definitive version is available at www3.interscience.wiley.com
Options for field diagnosis of human African trypanosomiasis (2005)
Chappuis, F., Loutan, L., Simarro, P., Lejon, V., Büscher, P.
Human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense or T. b. rhodesiense remains highly prevalent in several rural areas of sub-Saharan Africa and is lethal if left untreated....
The definitive version is available at www3.interscience.wiley.com
Lejon, V., Claes, F., Verloo, D., Maina, M., Urakawa, T., Majiwa, P. A. O., ...
The transcript encoding a predominant Trypanosoma evansi variable surface glycoprotein RoTat 1.2 was cloned and expressed as a recombinant protein in Spodoptera frugiperda and Trichoplusia ni...
Jamonneau, V., Solano, P., Garcia, A., Lejon, V., Djé, N., Miezan, T. W., ...
The definitive version is available at www3.interscience.wiley.com
The challenge of Trypanosoma brucei gambiense sleeping sickness diagnosis outside Africa (2003)
Lejon, V., Boelaert, M., Jannin, J., Moore, A., Büscher, P.
Sleeping sickness is a lethal African disease caused by parasites of the Trypanosoma brucei subspecies, which is transmitted by tsetse flies. Occasionally, patients are reported outside Africa....
Towards saliva-based screening for sleeping sickness? (2003)
Lejon, V., Kwete, J., Büscher, P.
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Lejon, V., Legros, D., Savignoni, A., Gastellu Etchegorry, M., Mbulamberi, D., Büscher, P.
In a clinical trial on efficacy of Pentamidine in second stage Trypanosoma brucei gambiense patients with /=4 and LATEX/T.b. gambiense positive CSF, were associated with treatment failure.Detection...
Lejon, V., Rebeski, D. E., Ndao, M., Baelmans, R., Winger, E. M., Faye, D., ...
Indirect ELISAs using denatured antigen preparations of Trypanosoma (T.) congolense (TcAGd) and T. vivax (TvAGd) for detection of anti-trypanosome antibodies in bovine serum (I-TAB ELISAs), were...
Lejon, V., Reiber, H., Legros, D., Djé, N., Magnus, E., Wouters, I., ...
Diagnosis of central nervous system (CNS) involvement in human African trypanosomiasis is crucial in determination of therapy. Cerebrospinal fluid (CSF) and serum immunoglobulin concentrations,...
Lejon, V., Sindic, C. J. M., Van Antwerpen, M. P., Doua, F., Solano, P., Jamonneau, V., ...
Quantitative and qualitative techniques for assessment of the intrathecal humoral immune response in human African trypanosomiasis were compared, and their diagnostic potential for detection of the...
Bisser, S., Lejon, V., Preux, P. M., Bouteille, B., Stanghellini, A., Jauberteau, M. O., ...
Diagnosis of central nervous system (CNS) involvement in sleeping sickness is crucial in order to give an appropriate treatment regimen. Neurological symptoms occur late, therefore field diagnosis is...
Le diagnostic du stade dans la maladie du sommeil: vers une nouvelle approche (2002)
Diagnosis of the neurological disease stage in Trypanosoma brucei (T.b.) gambiense infection is essential to select an optimal chemotherapy. The actual parameters for stage determination, the...
Lejon, V., Lardon, J., Kenis, G., Pinoges, L., Legros, D., Bisser, S., ...
Serum and cerebrospinal fluid (CSF) concentrations of interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-alpha and interferon-gamma were determined in 46 Trypanosoma brucei gambiense sleeping...
Lejon, V., Legros, D., Richer, M., Ruiz, J. A., Jamonneau, V., Truc, P., ...
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Magnus, E., Lejon, V., Bayon, D., Buyse, D., Simarro, P., Verloo, D., ...
CATT/Trypanosoma brucei gambiense, a direct card agglutination test designed for field surveys on human African trypanosomosis, is currently used with freshly collected heparinized blood samples....
Solano, P., Jamonneau, V., N'Guessan, P., N'Dri, L., Dje, N. N., Miezan, T. W., ...
During a medical survey the sleeping sickness focus in Bonon, Ivory Coast, PCR with Trypanosoma brucei specific primers (TBR 1-2 from Parasitology 99 (1989) 57) was tested on DNA derived from blood...
Truc, P., Lejon, V., Magnus, E., Jamonneau, V., Nangouma, A., Verloo, D., ...
OBJECTIVE: To evaluate the performance of serological tests using dried blood on filter-papers (micro-card agglutination test for trypanosomiasis (micro-CATT)) performed under field and laboratory...
Faye, D., Osaer, S., Goossens, B., Van Winghem, J., Dorny, P., Lejon, V., ...
Forty pure West African Dwarf (WAD) goats and 35 of its F1 crosses with the Sahelian breed were used in a multifactorial experimental design to evaluate the effects of an experimental Trypanosoma...
Stage determination and follow-up in sleeping sickness (2001)
In order to select a correct treatment after primary diagnosis of trypanosomiasis infection, accurate assessment of the disease stage, haemo-lymphatic or meningo-encephalitic, is essential. This is...
Lejon, V., Legros, D., Rosengren, L., Gastellu Etchegorry, M., Büscher, P.
Concentrations of glial fibrillary acidic protein (GFAp) and light subunit neurofilament protein (NFL) in cerebrospinal fluid (CSF) were measured in patients with second-stage Trypanosoma brucei...
Le diagnostic de la trypanosomiase humaine africaine en 2001 (2001)
Louis, F. J., Büscher, P., Lejon, V.
Human African trypanosomiasis is characterized by a non-specific clinical presentation with no consistent, pathognomonic manifestations. However definite diagnosis is necessary to avoid unnecessary...
Lejon, V., Büscher, P., Bisser, S., Legros, D., Richer, M., Truc, P., ...
Cytokine concentrations in serum and cerebrospinal fluid of sleeping sickness patients (2001)
Lejon, V., Lardon, J., Kenis, G., Bisser, S., Büscher, P., Bosmans, E., ...
Garcia, A., Jamonneau, V., Magnus, E., Laveissière, C., Lejon, V., N'Guessan, P., ...
The definitive version is available at www3.interscience.wiley.com
Lejon, V., Büscher, P., Sema, N. H., Magnus, E., Van Meirvenne, N.
LATEX/IgM, a rapid agglutination test for the semi-quantitative detection of IgM in cerebrospinal fluid of patients with African trypanosomiasis, is described in this article. The lyophilized reagent...