Toxicology of Nanomaterials: Permanent interactive learning (2009)
Abstract Particle and Fibre Toxicology wants to play a decisive role in a time where particle research is challenged and driven by the developments and applications of nanomaterials. This aim is not...
JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma (2009)
Chang, Qingshan, Chen, Jianguo, Beezhold, Kevin J, Castranova, Vince, Shi, Xianglin, Chen, Fei
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with an extremely poor prognosis. The classification of HCC based on the molecular signature is not...
Imaging, Diagnosis, Prognosis Predicting Cancer Drug Response by Proteomic Profiling (2008)
Yan Ma, Zhenyu Ding, Yong Qian, Xianglin Shi, Vince Castranova, E. James Harner, ...
Abstract Purpose: Accurate prediction of an individual patient’s drug response is an important prerequisite of personalized medicine. Recent pharmacogenomics research in chemosensitivity prediction...
5. Differential Expression of the Identified Marker Genes between Cancer and (2008)
Lan Guo, Yan Ma, Rebecca Ward, Vince Castranova, Xianglin Shi, Yong Qian
Nucleolin links to arsenic-induced stabilization of GADD45{alpha} mRNA (2006)
Zhang, Yadong, Bhatia, Deepak, Xia, Hongfeng, Castranova, Vince, Shi, Xianglin, Chen, Fei
The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial...
Nucleolin links to arsenic-induced stabilization of GADD45a mRNA (2005)
Yadong Zhang, Deepak Bhatia, Hongfeng Xia, Vince Castranova, Xianglin Shi, Fei Chen
The present study shows that arsenic induces GADD45a (growth arrest and DNA damage inducible gene 45a) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial cell...
Effect of Cr(VI) Exposure on Sperm Quality: Human and Animal Studies (2001)
Li, Hong, Chen, Qiongyu, Li, Shien, Yao, Wu, Li, Linghong, Shi, Xianglin, ...
The semen status of male workers occupationally exposed to hexavalent chromium(VI) was investigated. Sperm counts from exposed workers were 47.05±2.13×106/ml and those from control group...
Vanadate-induced activation of activator protein-1: role of reactive oxygen species (1999)
Ding, Min, Li, Jian-Jian, Leonard, Stephen S., Ye, Jian-Ping, Shi, Xianglin, Colburn, Nancy H., ...
The present study was undertaken to test the hypothesis that the toxicity and carcinogenicity of vanadium might arise from elevation of reactive oxygen species leading to activation of the...
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway
Chen, Fei, Zhang, Zhuo, Bower, Jacquelyn, Lu, Yongju, Leonard, Stephen S., Ding, Min, ...
Arsenite is a known human carcinogen that induces tumorigenesis through either a genotoxic or an epigenetic mechanism. In this study, the effect of arsenite on cell cycle regulation and the...
Ma, Jane Y C, Rengasamy, Apavoo, Frazer, Dave, Barger, Mark W, Hubbs, Ann F, Battelli, Lori, ...
Asphalt fumes are complex mixtures of various organic compounds, including polycyclic aromatic hydrocarbons (PAHs). PAHs require bioactivation by the cytochrome P-450 monooxygenase system to exert...
The Sources of Inflammatory Mediators in the Lung after Silica Exposure
Rao, K. Murali Krishna, Porter, Dale W., Meighan, Terence, Castranova, Vince
The expression of 10 genes implicated in regulation of the inflammatory processes in the lung was studied after exposure of alveolar macrophages (AMs) to silica in vitro or in vivo. Exposure of AMs...
Nucleolin links to arsenic-induced stabilization of GADD45α mRNA
Zhang, Yadong, Bhatia, Deepak, Xia, Hongfeng, Castranova, Vince, Shi, Xianglin, Chen, Fei
The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial...
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway
Chen, Fei, Zhang, Zhuo, Bower, Jacquelyn, Lu, Yongju, Leonard, Stephen S., Ding, Min, ...
Arsenite is a known human carcinogen that induces tumorigenesis through either a genotoxic or an epigenetic mechanism. In this study, the effect of arsenite on cell cycle regulation and the...
Ma, Jane Y C, Rengasamy, Apavoo, Frazer, Dave, Barger, Mark W, Hubbs, Ann F, Battelli, Lori, ...
Asphalt fumes are complex mixtures of various organic compounds, including polycyclic aromatic hydrocarbons (PAHs). PAHs require bioactivation by the cytochrome P-450 monooxygenase system to exert...
The Sources of Inflammatory Mediators in the Lung after Silica Exposure
Rao, K. Murali Krishna, Porter, Dale W., Meighan, Terence, Castranova, Vince
The expression of 10 genes implicated in regulation of the inflammatory processes in the lung was studied after exposure of alveolar macrophages (AMs) to silica in vitro or in vivo. Exposure of AMs...
Nucleolin links to arsenic-induced stabilization of GADD45α mRNA
Zhang, Yadong, Bhatia, Deepak, Xia, Hongfeng, Castranova, Vince, Shi, Xianglin, Chen, Fei
The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial...
Lewis, John A., Rao, K. Murali Krishna, Castranova, Vince, Vallyathan, Val, Dennis, William E., Knechtges, Paul L.
Nitric Oxide Inhibits HIV Tat-Induced NF-κB Activation
Chen, Fei, Lu, Yongju, Castranova, Vince, Rojanasakul, Yon, Miyahara, Kaoru, Shizuta, Yutaka, ...
To evaluate the roles of nitric oxide (NO) on human immunodeficiency virus (HIV) Tat-induced transactivation of HIV long terminal repeat (HIV-LTR), we examined the effect of NO in the regulation of...
New Insights into the Role of Nuclear Factor-κB in Cell Growth Regulation
Chen, Fei, Castranova, Vince, Shi, Xianglin
The nuclear factor (NF)-κB family of eukaryotic transcription factors plays an important role in the regulation of immune response, embryo and cell lineage development, cell apoptosis, cell-cycle...
Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity
Shvedova, Anna A., Fabisiak, James P., Kisin, Elena R., Murray, Ashley R., Roberts, Jenny R., Tyurina, Yulia Y., ...
Carbon nanotubes (CNT), with their applications in industry and medicine, may lead to new risks to human health. CNT induce a robust pulmonary inflammation and oxidative stress in rodents. Realistic...
Jiang, Yanyan, Wen, Ke, Zhou, Xueping, Schwegler-Berry, Diane, Castranova, Vince, He, Pingnian
Combining single-vessel perfusion technique with confocal microscopy, this study presents a new approach that allows three-dimensional visualization and quantification of endothelial gaps under...
JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma
Chang, Qingshan, Chen, Jianguo, Beezhold, Kevin J, Castranova, Vince, Shi, Xianglin, Chen, Fei
Toxicology of Nanomaterials: Permanent interactive learning
Particle and Fibre Toxicology wants to play a decisive role in a time where particle research is challenged and driven by the developments and applications of nanomaterials. This aim is not merely...