Armstrong, D.S., Arvieux, J., Asaturyan, R., Averett, T., Bailey, S.L., Batigne, G., ...
We have measured parity-violating asymmetries in elastic electron-proton scattering over the range of momentum transfers 0.12 $\leq$ Q$^2$ \leq$ 1.0 GeV$^2$. These asymmetries, arising from...
Transverse beam spin asymmetries in forward-angle elastic electron-proton scattering (2007)
Armstrong, D.S., Arvieux, J., Asaturyan, R., Averett, T., Bailey, S.L., Batigne, G., ...
We have measured the beam-normal single-spin asymmetry in elastic scattering of transversely-polarized 3 GeV electrons from unpolarized protons at Q^2 values of 0.15 and 0.25 (GeV/c)^2 with results...
Lippert, E., Falk, W., Bataille, F., Kaehne, T., Naumann, M., Goeke, M., ...
BACKGROUND: Colonic lamina propria fibroblasts (CLPFs) play an important role in the pathogenesis of fibrosis and strictures in Crohn's disease. AIM: To identify colonic epithelial cell (CEC)-derived...
Arvieux, J, Asaturyan, R, Averett, T, Bailey, S L, Batigne, G, ...
We have measured parity-violating asymmetries in elastic electron-proton scattering over the range of momentum transfers 0.12 < or =Q2 < or =1.0 GeV2. These asymmetries, arising from interference of...
Armstrong, D.S., Arvieux, J., Asaturyan, R., Averett, T., Bailey, S.L., Batigne, G., ...
We have measured parity-violating asymmetries in elastic electron-proton scattering over the range of momentum transfers 0.12 $\leq$ Q$^2$ \leq$ 1.0 GeV$^2$. These asymmetries, arising from...
Armstrong, D.S., Arvieux, J., Asaturyan, R., Averett, T., Bailey, S.L., Batigne, G., ...
We have measured parity-violating asymmetries in elastic electron-proton scattering over the range of momentum transfers 0.12 $\leq$ Q$^2$ \leq$ 1.0 GeV$^2$. These asymmetries, arising from...
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. (2000)
Steidler, Lothar, Hans, Wolfgang, Schotte, Lieven, Neirynck, Sabine, OBERMEIER, F, FALK, W, ...
Record load, 150 bales, weight 17 tons 12 cwts 1 qr 15 lbs, T. Baywater, Carrier [picture] / (1913)
Title from caption.; Condition: Good.; Part of the collection: Photographs of the Australian bush in the area of the Brotherhood of the Good Shepherd, Dubbo, N.S.W.; Plate NL24267--Information on...
Record load, 150 bales, weight 17 tons 12 cwts 1 qr 15 lbs, T. Baywater, Carrier [picture] / (1913)
Title from caption.; Condition: Good.; Part of the collection: Photographs of the Australian bush in the area of the Brotherhood of the Good Shepherd, Dubbo, N.S.W.; Plate NL24267--Information on...
Zawatzky, R, Wurmbaeck, H, Falk, W, Homfeld, A
In macrophages from inbred mice, the magnitude of the interferon (IFN) response to Newcastle disease virus (NDV) infection is under genetic control of the If-1 locus, which carries the allele for...
Optimal activation of human monocytes in vitro for the biosynthesis of tumor necrosis factor was achieved only with complete S-form lipopolysaccharide. Endotoxin preparations with shorter...
Männel, D N, Falk, W, Meltzer, M S
Mouse peritoneal macrophages activated for tumor cytotoxicity by any of several in vivo or in vitro treatments released a soluble cytotoxin into culture fluids only after exposure to small amounts of...
Falk, W, Harvath, L, Leonard, E J
Human peripheral blood monocytes comprise a subpopulation of 20 to 40% that is capable of responding to chemoattractants and a remaining subpopulation that cannot respond. We were able to obtain...
Chemotaxis of purified human monocytes in vitro: lack of accessory cell requirement.
This study was undertaken to determine whether cell cooperation, either among monocytes or between monocytes and lymphocytes, is a prerequisite for monocyte chemotactic responsiveness. We compared...
Specificity and reversibility of chemotactic deactivation of human monocytes.
The chemotactic deactivation of human monocytes was studied to provide insight into the mechanism of chemotaxis. Deactivation was dependent on the dose of chemoattractant and time of incubation. A...
Only 20 to 40% of human blood monocytes were capable of responding to chemotaxins in vitro. This limit is not due to restrictions of the in vitro system, but is due to the existence of a migrating...
Zawatzky, R, Wurmbaeck, H, Falk, W, Homfeld, A
In macrophages from inbred mice, the magnitude of the interferon (IFN) response to Newcastle disease virus (NDV) infection is under genetic control of the If-1 locus, which carries the allele for...
Optimal activation of human monocytes in vitro for the biosynthesis of tumor necrosis factor was achieved only with complete S-form lipopolysaccharide. Endotoxin preparations with shorter...
Männel, D N, Falk, W, Meltzer, M S
Mouse peritoneal macrophages activated for tumor cytotoxicity by any of several in vivo or in vitro treatments released a soluble cytotoxin into culture fluids only after exposure to small amounts of...
Falk, W, Harvath, L, Leonard, E J
Human peripheral blood monocytes comprise a subpopulation of 20 to 40% that is capable of responding to chemoattractants and a remaining subpopulation that cannot respond. We were able to obtain...
Chemotaxis of purified human monocytes in vitro: lack of accessory cell requirement.
This study was undertaken to determine whether cell cooperation, either among monocytes or between monocytes and lymphocytes, is a prerequisite for monocyte chemotactic responsiveness. We compared...
Specificity and reversibility of chemotactic deactivation of human monocytes.
The chemotactic deactivation of human monocytes was studied to provide insight into the mechanism of chemotaxis. Deactivation was dependent on the dose of chemoattractant and time of incubation. A...
Only 20 to 40% of human blood monocytes were capable of responding to chemotaxins in vitro. This limit is not due to restrictions of the in vitro system, but is due to the existence of a migrating...
Schadlich, H., Ermann, J., Biskop, M., Falk, W., Sperling, F., Jungel, A., ...
OBJECTIVES—To evaluate in vivo the contribution of tumour necrosis factor α (TNFα) to the chimeric transfer model of human rheumatoid arthritis synovial membrane into SCID mice (hu/mu SCID...
Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease.
Daig, R, Andus, T, Aschenbrenner, E, Falk, W, Schölmerich, J, Gross, V
To test whether there is a difference in the expression of interleukin 8 (IL8) between Crohn's disease and ulcerative colitis and to determine the main site of its synthesis this study analysed IL8...
Gelbmann, C, Mestermann, S, Gross, V, Kollinger, M, Scholmerich, J, Falk, W
BACKGROUND/AIMS—Intestinal fibrosis and stricture formation is an unresolved problem in Crohn's disease. The aim of this study was to investigate whether mast cells accumulate in these tissues and...
Daig, R, Rogler, G, Aschenbrenner, E, Vogl, D, Falk, W, Gross, V, ...
BACKGROUND—There is growing evidence that intestinal epithelial cells (IECs) are involved in the mucosal immune system. AIM—To assess the pattern of cytokines secreted by IECs and lamina...
Gelbmann, C M, Leeb, S N, Vogl, D, Maendel, M, Herfarth, H, Schölmerich, J, ...
Background: CD40 has been shown to be a functional activation antigen on a variety of cell types involved in immune responses. As intestinal fibroblasts and myofibroblasts may play a role during...
OBERMEIER, F, DUNGER, N, STRAUCH, U G, GRUNWALD, N, HERFARTH, H, SCHÖLMERICH, J, ...
Intestinal inflammation in inflammatory bowel disease (IBD) and experimental models of colitis is characterized by a dysregulated intestinal immune response with elevated levels of Th1 cytokines. The...
Cathepsin D is up-regulated in inflammatory bowel disease macrophages
HAUSMANN, M, OBERMEIER, F, SCHREITER, K, SPOTTL, T, FALK, W, SCHÖLMERICH, J, ...
Down-regulation of receptors involved in the recognition or transmission of inflammatory signals and a reduced responsiveness support the concept that macrophages are ‘desensitized’ during their...
STOPFER, P, OBERMEIER, F, DUNGER, N, FALK, W, FARKAS, S, JANOTTA, M, ...
The lymphotoxin-β receptor (LTβR) pathway is critical for maintenance of organized lymphoid structures and is involved in the development of colitis. To investigate the mechanisms by which LTβR...
KOJOUHAROFF, G, HANS, W, OBERMEIER, F, MÄNNEL, D N, ANDUS, T, SCHÖLMERICH, J, ...
The cytokines TNF and IL-1 have been implicated as mediators of the inflammatory processes in patients with inflammatory bowel disease (IBD). To investigate the role of these cytokines in mucosal...
Isolation and phenotypic characterization of colonic macrophages
Rogler, G, Hausmann, M, Vogl, D, Aschenbrenner, E, Andus, T, Falk, W, ...
Macrophages play an important role in the intestinal mucosal immune system. However, they are a poorly defined cell population. We therefore determined their phenotype in normal colonic mucosa....
Obermeier, F, Kojouharoff, G, Hans, W, Schölmerich, J, Gross, V, Falk, W
Excess nitric oxide formation caused by the activity of the inducible nitric oxide synthase has been implicated as a toxic effector molecule in the pathogenesis of experimental colitis and...
Herfarth, H, Brand, K, Rath, H C, Rogler, G, Schölmerich, J, Falk, W
In acute DSS-induced colitis nuclear factor (NF)-κ B-dependent inflammatory cytokines including IL-1 and tumour necrosis factor-alpha (TNF-α) are up-regulated. Here we examined the effects of...
Hausmann, M, Spöttl, T, Andus, T, Rothe, G, Falk, W, Schölmerich, J, ...
Macrophages play a central role during the pathogenesis of inflammation. In normal intestinal mucosa surface expression of typical macrophage markers such as CD14, CD16, CD11b or T-cell...
A study of waiting time in an emergency department
Allen, A. B., Barnard, B. G., Falk, W., Higgs, E. R., McCracken, J. G.
A study was undertaken to determine the time spent by 3459 patients in the Emergency Department of the hospital and also to assess whether full-time physician supervision of interns appreciably...
Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes
Spoettl, T, Hausmann, M, Herlyn, M, Gunckel, M, Dirmeier, A, Falk, W, ...
Monocytes (MO) migrating into normal, non-inflamed intestinal mucosa undergo a specific differentiation resulting in a non-reactive, tolerogenic intestinal macrophage (IMAC). Recently we demonstrated...
Menzel, K, Hausmann, M, Obermeier, F, Schreiter, K, Dunger, N, Bataille, F, ...
The cathepsins D (CTSD), B (CTSB) and L (CTSL) are important for the intracellular degradation of proteins. Increased cathepsin expression is associated with inflammatory diseases. We have shown...
Esparza, I, Mannel, D, Ruppel, A, Falk, W, Krammer, PH
Macrophages play a crucial role in the defense against tumors and parasites. Activation of tumoricidal and microbicidal effector mechanisms requires stimulation of macrophages with...
Hausmann, M, Obermeier, F, Paper, D H, Balan, K, Dunger, N, Menzel, K, ...
Recently we demonstrated that in inflammatory bowel disease (IBD) macrophage-oxidative burst activity is increased and NADPH oxidase mRNA is induced. The herbal phenylethanoid acteoside isolated from...
Schreiter, K, Hausmann, M, Spoettl, T, Strauch, U G, Bataille, F, Schoelmerich, J, ...
Background: The glycoprotein (gp) 96 links the adaptive with the innate immune system. It is a chaperone with a binding domain for peptides generated by proteasomal degradation. During cellular...
Straub, R H, Stebner, K, Härle, P, Kees, F, Falk, W, Schölmerich, J
Background: In the intestinal tract, the role of sympathetic neurotransmitters has been largely ignored in mucosal neuroimmunology.
Obermeier, F, Strauch, U G, Dunger, N, Grunwald, N, Rath, H C, Herfarth, H, ...
Background and methods: Cytosin-guanosin dinucleotide (CpG) motifs of bacterial DNA are known to be potent activators of innate immunity. We have shown previously that administration of CpG...
Regulation of galectin-3 function in mucosal fibroblasts: potential role in mucosal inflammation
Lippert, E, Gunckel, M, Brenmoehl, J, Bataille, F, Falk, W, Scholmerich, J, ...
Recently we identified galectin-3 (gal-3), which is secreted by colonic epithelial cells (CEC), to be a strong activator of colonic lamina propria fibroblasts (CLPF). Modulation of CLPF function may...
A ticket to the gut for thymic T cells
The intestinal epithelium is colonised by, among other cells, normal T helper and cytotoxic T cells which obtain their antigen experience in the gut associated lymphatics after migration from the...
Hausmann, M, Paul, G, Kellermeier, S, Frey, I, Schölmerich, J, Falk, W, ...
Haem oxygenase-1 (HO-1) up-regulation was suggested to reduce mucosal tissue damage in inflammatory bowel disease (IBD) and an up-regulation of HO-1 expression in patients with Crohn's disease (CD)...