Scientific Commons: W. J. A. Boersma

The Effect of Low-Density Broiler Breeder Diets on Performance and Immune Status of their Offspring (2007)

Enting, H., Boersma, W.J.A., Cornelissen, J.B.W.J., Winden, S.C.L., Van, Verstegen, M.W.A., Aar, P.J., Van De

Effects of low-density broiler breeder diets on offspring performance and mortality were studied using 2,100 female and 210 male Cobb 500 breeders. Breeder treatments involved 4 experimental groups...

Immune reactions to an Eimeria acervulina infection in different broilers lines (2007)

Swinkels, W., Post, J., Cornelissen, J.B.W.J., Engel, B., Boersma, W.J.A., Rebel, A.M.J.

The (T-cell) immune responses of two different broiler lines to a primary Eimeria acervulina infection were investigated. The lines used were a commercial fast-growing broiler line and a slow-growing...

Immune responses to an Eimeria acervulina infection in different broilers lines (2007)

Swinkels, W.J.C., Post, J., Cornelissen, J.B.W.J., Engel, B., Boersma, W.J.A., Rebel, J.M.J.

The (T-cell) immune responses of two different broiler lines to a primary Eimeria acervulina infection were investigated. The lines used were a commercial fast-growing broiler line and a slow-growing...

Reactions of fast-growing and slow-growing broiler lines against E. Acervulina (2007)

Swinkels, W.J.C., Post, J., Cornelissen, J.B.W.J., Engel, B., Boersma, W.J.A., Rebel, J.M.J.

A DNA vaccine coding for gB and gD of pseudorabies virus (suid herpes type 1) primes the immune system in the presence of maternal immunity more efficiently than conventional vaccines (2006)

Rooij, E.M.A., Van, Moonen-Leusen, H.W.M., Visser-Hendriksen, Y.E., De, Middel, W.G., Boersma, W.J.A., Bianchi, A.T.J.

DNA vaccines are capable of priming the immune system of neonates in the presence of maternal antibodies. However, it is still not clear whether the extent of priming and protection against challenge...

Immune responses to an Eimeria acervulina infection in different broilers lines (in press) (2006)

Swinkels, W.J.C., Post, J., Cornelissen, J.B.W.J., Engel, B., Boersma, W.J.A., Rebel, J.M.J.

Elimeria Acervulina infected one day old broilers compared to amount of Eimeria in duodenum measured by real time PCR. (2006)

Swinkels, W.J.C., Post, J., Cornelissen, J.B.W.J., Engel, B., Boersma, W.J.A., Rebel, J.M.J.

T-cell responses are supposed to be the major immune reactions in broilers infected with Eimeria. The nature of such T-cell responses is influenced by the species of Eimeria involved, age of the...

Age, gender and litter-related variation in T-lymphocyte cytokine production in young pigs (2005)

Groot, J., De, Kruijt, L., Scholten, J.W., Boersma, W.J.A., Buist, W.G., Engel, B., ...

The capacity of farm animals to produce cytokines could be an important determinant of robustness and health. From research in rodents and humans it appears that the production and the balance of T...

Development of domestic animal models for the study of the ontogeny of human disease (2005)

Groot, J., De, Boersma, W.J.A., Staay, F.J., Van Der, Niewold, T., Stockhofe, N., Koopmans, S.J., ...

Fasciola hepatica procathepsin L3 protein expressed by a baculovirus recombinant can partly protect rats against faciolosis (2005)

Reszka, N., Cornelissen, J.B.W.J., Harmsen, M.M., Bienkowska-Szewczyk, K., Bree, J., De, Boersma, W.J.A., ...

Fasciola hepatica juveniles express immunodominant cathepsin L proteins, which are mainly found in their immature, procathepsin form. A gene encoding such a procathepsin L (FheCL3) was expressed by a...

Cytokine responses in broiler lines that differ in susceptibility to malabsorption syndrome (2005)

Rebel, J.M.J., Balk, F.R.M., Boersma, W.J.A.

1. Based on earlier studies it was hypothesised that there is an immunological basis for the differences in susceptibility to malabsorption syndrome (MAS). A study was conducted to investigate...

Management en de weerstand van varkens = Management and the robusness of pigs (2005)

Mul, M.F., Niewold, T.A., Boersma, W.J.A., Rooij, A.M.A., Van

Dit rapport geeft een indruk van de werking van de weerstand van het varken, de factoren die daarop mogelijk van invloed zijn en de methoden om weerstand te meten.

Development of domestic animal models for the study of the ontogeny of human disease (2005)

Groot, J., De, Boersma, W.J.A., Staay, F.J., Van Der, Niewold, T.A., Stockhofe, N., Koopmans, S.J., ...

The development of biologically relevant animal models fot the study of the ontogeny of human disease (2005)

Groot, J, De, Boersma, W.J.A., Staay, F.J., Van Der, Niewold, Th., Stockhofe, N., Koopmans, S.J., ...

Age gender and litter-related variation in T-lymphocyte cytokine production in young pigs (2005)

Groot, J., De, Kruijt, L., Scholten, J.W., Boersma, W.J.A., Buist, W.G., Engel, B., ...

The capacity of farm animals to produce cytokines could be an important determinant of robustness and health. From research in rodents and humans it appears that the production and the balance of T...

Fasciola hepatica procathepsin L3 protein expressed by a baculovirus recombinant can partly protect rats against fasciolosis (2005)

Reszka, N., Cornelissen, J.B.W.J., Harmsen, M.M., Bree, J., De, Boersma, W.J.A., Rijsewijk, F.A.M.

Fasciola hepatica juveniles express immunodominant cathepsin L proteins, which are mainly found in their immature, procathepsin form. A gene encoding such a procathepsin L (FheCL3) was expressed by a...

Cytokine responses in broilers that differ in susceptibility to malabsorption syndrome. (2005)

Rebel, J.M.J., Balk, F.R.M., Boersma, W.J.A.

1. Based on earlier studies it was hypothesised that there is an immunological basis for the differences in susceptibility to malabsorption syndrome (MAS). A study was conducted to investigate...

Vaccine-induced T cellsmediated immunity plays a critical role in early protection against pseudorabies virus infection in pigs (2004)

Rooij, E.M.A., Van, Bruin, M.G.M., De, Visser, Y.E., De, Middel, W.G., Boersma, W.J.A., Bianchi, A.T.J.

The aim of our study was to evaluate the relative importance of antibody and T cell-mediated immunity in protection against pseudorabies virus (suid herpes virus type 1) infection in pigs. We induced...

Immunomodulation by probiotic lactobacilli in layer and meat-type chickens (2004)

Koenen, M.E., Kramer, J., Hulst-van Arkel, M.C., Van Der, Heres, L., Jeurissen, S.H.M., Boersma, W.J.A.

1. The aim of the experiments was to evaluate whether selected probiotic lactobacillus strains have different immunomodulating effects in layer- and meat-type strain chickens. 2. Humoral and cellular...

Development and validation of a new in vitro assay for selection of probiotic bacteria that express immunestimulating properties in chickens in vivo (2004)

Koenen, M.E., Hulst, R.G.M., Van Der, Leering, M., Jeurissen, S.H.M., Boersma, W.J.A.

Oral administration of immunoprobiotic bacteria may support animal health. Species specificity of such microorganisms requires appropriate selection. An in vitro assay for the selection of...

Vaccinations in pig health care in the Netherlands - analysis of a questionnaire among veterinarians (2004)

Groot, J., De, Eijck, I.A.J.M., Boersma, W.J.A.

Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide (2004)

Harmsen, M.M., Cornelissen, J.B.W.J., Buys-Bergen, W.E.C.M., Boersma, W.J.A., Jeurissen, S.H.M., Milligen, F.J.

Cathepsin L (CL)-like proteases are important candidate vaccine antigens for protection against helminth infections. We previously identified an immunogenic 32 kDa protein specifically present in...

Prenatal cortisol exposure affects sensitivity to LPS in young pigs (2004)

Groot, J., De, Kranendonk, G., Hopster, H., Wolthuis-Fillerup, M., Reenen, C.G., Van, Hodgson, D., ...

Determinants of Th1/Th2-cytokine production in young domestic pigs (2004)

Groot, J., De, Kruijt, L., Scholten, W., Boersma, W.J.A., Buist, W.G., Engel, B., ...

The presence of co-infections in pigs with clinical signs of PMWS in the Nethrlands: a case-control study (2004)

Wellenberg, G.J., Stockhofe, N., Boersma, W.J.A., Jong, M.F., Elbers, A.R.W.

In this study, 60 pigs with clinical signs of post-weaning multisystemic wasting syndrome (PMWS) from 20 different pig herds and 180 control pigs (without clinical signs of PMWS) were examined to get...

Vaccinaties in de Nederlandse varkensgezondheidszorganalyse van een enquete onder dierenartsen (2004)

Groot, J., De, Eijck, I.A.J.M., Boersma, W.J.A.

Excessive porcine circovirus type 2 antibody titres may trigger the development of porcine dermatitis and nephropathy syndrome: a case-control study (2004)

Wellenberg, G.J., Stockhofe, N., Jong, M.F., Boersma, W.J.A., Elbers, A.R.W.

In a case-control study, the role of porcine circovirus 2 (PCV2) and putative co-factors in the development of porcine dermatitis and nephropathy syndrome (PDNS) were investigated. Pigs with and...

Identification of a novel and inefficiently processed cathepsin L. protease in Fasciola hepatica and involvement of the propeptide in inducing protection in rats (2004)

Harmsen, M.M., Cornelissen, J.B.W.J., Buys-Bergen, W.E.C.M., Boersma, W.J.A., Jeurissen, S.H.M., Milligen, F.J.

Cathepsin L (CL)-like proteases are important candidate vaccine antigens for protection against helminth infections. We previously identified an immunogenic 32 kDa protein specifically present in...

Elektromagnetische straling als immunstimulator na vaccinatie bij biggen (2004)

Eijck, I.A.J.M., Boersma, W.J.A., Cornelissen, J.B.W.J.

Vaccine-induced T cell-mediated immunity plays a critical role in early protection against pseudorabies virus (suid herpes virus type 1) infection in pigs (2004)

Rooij, E.M.A., Van, Bruin, M.G.M., De, Visser-Hendriksen, Y.E., De, Middel, W.G., Boersma, W.J.A., Bianchi, A.T.J.

Growth phase of orally administered Lactobacillus strains differentially affects T helper-cell pathways (2003)

Maassen, C.B.M., Boersma, W.J.A., Holten-Neelen, J.C.P.A., Van, Claassen, E.A.W., Laman, J.D.

Lactobacillus strains with probiotic activity are major constituents of numerous common food products. Due to their `generally regarded as safe¿-status (GRAS-status), Lactobacillus strains can also...

Growth phase of orally administrated Lactobacillus strains differentially affects IgG1/IgG2 ratio for soluble antigens: implications for vaccine development (2003)

Maassen, C.B.M., Boersma, W.J.A., Holten-Neelen, J.C.P.A., Van, Claassen, E.A.W., Laman, J.D.

Lactobacillus strains with probiotic activity are major constituents of numerous common food products. Due to their `generally regarded as safe¿-status (GRAS-status), Lactobacillus strains can also...

PDNS affected pigs have extremely high levels of PCV2 antibodies: case-control study (2003)

Wellenberg, G.J., Stockhofe-Zurwieden, N., Boersma, W.J.A., Elbers, A., Jong, M., De

What are probiotics? Attempts to functional definition of probiotics to improve credibility of probiotics in support of animal health (2003)

Boersma, W.J.A.

Infections of european and american type PRRSV in PMWS affected pits: a case-control study (2003)

Wellenberg, G.J., Stockhofe-Zurwieden, N., Boersma, W.J.A., Elbers, A., Jong, M., De

Reduced experimental autoimmune encephalomyelitis after intranasal and oral administration of recombinant lactobacilli expressing meyelin antigens (2003)

Maassen, C.B.M., Holten-Neelen, J.C.P.A., Van, Groenewegen, L., Hoogteijling, L, Visser, L., Boersma, W.J.A.

Oral administration of autoantigens is a safe and convenient way to induce peripheral T-cell tolerance in autoimmune diseases like multiple sclerosis (MS). To increase the efficacy of oral tolerance...

Social stress in male mice impairs long-term antiviral immunity selectively in wounded subjects (2002)

Groot, J., De, Boersma, W.J.A., Scholten, J.W., Koolhaas, J.M.

An important property of the antiviral immune response is its time-dependent character. Beginning with a few antigen-specific cells upon infection, it evolves to a stage where there is an abundance...

Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvant (2002)

Rooij, E.M.A., Van, Glansbeek, H.L., Hilgers, L.A.T., Lintelo, E.G., Te, Visser, Y.E., De, Boersma, W.J.A., ...

To enhance the efficacy of a DNA vaccine against pseudorabies virus (PRV), we evaluated the adjuvant properties of plasmids coding for gamma interferon or interleukin-12, of CpG immunostimulatory...

Oral immunisation of naive and primed animals with transgenic potato tubers expressing LT-B (2001)

Lauterslager, T.G.M., Florack, D.E.A., Wal, T.J., Van Der, Molthoff, J.W., Langeveld, J.P.M., Bosch, D., ...

The efficacy of edible vaccines produced in potato tubers was examined in mice. Transgenic plants were developed by Agrobacterium tumefaciens-mediated transformation. The antigen selected was the...

Summary of workshop findings for porcine B-cell markers (2001)

Boersma, W.J.A., Zwart, R.J., Sinkora, J., Rehakova, Z., Haverson, K., Bianchi, A.T.J.

Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease (2001)

Cornelissen, J.B.W.J., Gaasenbeek, C.P.H., Borgsteede, F.H.M., Holland, W.G., Harmsen, M.M., Boersma, W.J.A.

Long-term effects of social stress on antiviral immunity in pigs (2001)

Groot, J., De, Ruis Marko, A.W., Scholten, J.W., Koolhaas, J.M., Boersma, W.J.A.

Summary of the first round analyses of the Third International Workshop on Swine Leukocyte Differentiation Antigens (2001)

Haverson, K., Saalmuller, A., Chen, Z., Huang, C.A., Simon, A., Seebach, J., ...

Oral immunisation of naive and primed animals with transgenic potato tubers expressing LT-B (2001)

Lauterslager, T.G.M., Florack, D.E.A., Wal, T.J., Van Der, Molthoff, J.W., Langeveld, J.P.M., Bosch, D., ...

Characterization of monoclonal antibodies recognizing immunoglobulin k and l chains in pigs by flowcytometry (2001)

Sinkora, J., Rehakova, Z., Samankova, L., Haverson, K., Butler, J.E., Zwart, R., ...