Netting neutrophils in autoimmune small-vessel vasculitis (2009)
Kessenbrock, K., Krumbholz, M., Schönermarck, U., Back, W., Gross, W. L., Werb, Z., ...
Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular...
Hunzelmann, N., Genth, E., Krieg, T., Lehmacher, W., Melchers, I., Meurer, M., ...
Objective. Systemic sclerosis (SSc) is a rare, heterogeneous disease, which affects different organs and therefore requires interdisciplinary diagnostic and therapeutic management. To improve the...
Metzler, C., Miehle, N., Manger, K., Iking-Konert, C., De Groot, K., Hellmich, B., ...
Objectives. Results from open-label trials suggest that methotrexate (MTX) and leflunomide (LEF) are effective for maintenance of remission in Wegener's granulomatosis (WG), but data from randomized...
Acute coronary syndrome in Takayasu arteritis without elevation of acute phase parameters (2007)
Ahmadi-Simab, K., Hellmich, B., Holl-Ulrich, K., Fleischmann, C., Dourvos, O., Gross, W. L.
Acute coronary syndrome in Takayasu arteritis without elevation of acute phase parameters (2007)
Ahmadi-Simab, K., Hellmich, B., Holl-Ulrich, K., Fleischmann, C., Dourvos, O., Gross, W. L.
Acute coronary syndrome in Takayasu arteritis without elevation of acute phase parameters (2007)
Ahmadi-Simab, K., Hellmich, B., Holl-Ulrich, K., Fleischmann, C., Dourvos, O., Gross, W. L.
Maintenance of remission with leflunomide in Wegener's granulomatosis (2004)
Metzler, C., Fink, C., Lamprecht, P., Gross, W. L., Reinhold-Keller, E.
Objective. To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG). Methods. This was a Phase II,...
Maintenance of remission with leflunomide in Wegener's granulomatosis (2004)
Metzler, C., Fink, C., Lamprecht, P., Gross, W. L., Reinhold-Keller, E.
Objective. To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG). Methods. This was a Phase II,...
High-dose intravenous azathioprine pulse treatment in refractory Wegener's granulomatosis (2004)
Aries, P. M., Hellmich, B., Reinhold-Keller, E., Gross, W. L.
Maintenance of remission with leflunomide in Wegener's granulomatosis (2004)
Metzler, C., Fink, C., Lamprecht, P., Gross, W. L., Reinhold-Keller, E.
Objective. To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG). Methods. This was a Phase II,...
Hellmich, B., Csernok, E., Haas, M. De, Borne, A.E.G.Kr. Von Dem, Schatz, H., Gross, W.L., ...
Effectiveness of TNF-{alpha} blockade with infliximab in refractory Wegener's granulomatosis (2002)
Lamprecht, P., Voswinkel, J., Lilienthal, T., Nolle, B., Heller, M., Gross, W. L., ...
Objective. To study the effect of the chimeric monoclonal anti‐tumour necrosis factor α (TNF‐α) antibody infliximab in the induction of remission in six patients refractory...
Csernok, E., Ahlquist, D., Ullrich, S., Gross, W. L.
Objective. To evaluate the performance of 11 commercial enzyme‐linked immunosorbent assay (ELISA) kits for the detection of antineutrophil cytoplasmic antibodies (ANCA)...
Reinhold-Keller, E., Herlyn, K., Wagner-Bastmeyer, R., Gutfleisch, J., Peter, H. H., Raspe, H. H., ...
Objective. To register all newly diagnosed patients with primary systemic vasculitis (PSV) in two large regions in north and south Germany. Methods. Between 1 January 1998 and 31...
Schönermarck, U., Lamprecht, P., Csernok, E., Gross, W. L.
Objectives. To evaluate the prevalence and association of antineutrophil cytoplasmic antibodies (ANCA) and their subtypes [proteinase 3 (PR3)‐ANCA, myeloperoxidase...
Retinal artery occlusion in Wegener's granulomatosis (2000)
Lamprecht, P., Lerin-Lozano, C., Reinhold-Keller, E., Nölle, B., Gross, W. L.
Reinhold-Keller, E., Zeidler, A., Gutfleisch, J., Peter, H. H., Raspe, H. H., Gross, W. L.
Objective. To investigate the period prevalences of primary systemic vasculitides (PSV) in urban and rural populations in northern and southern Germany in 1994. Methods. Questionnaires...
Mononeuritis secondary to rheumatoid arthritis responds to etanercept (2000)
Richter, C., Wanke, L., Steinmetz, J., Reinhold-Keller, E., Gross, W. L.
Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve.
Gross, W L, Bak, M I, Ingwall, J S, Arstall, M A, Smith, T W, Balligand, J L, ...
Cardiac myocytes express both constitutive and cytokine-inducible nitric oxide syntheses (NOS). NO and its congeners have been implicated in the regulation of cardiac contractile function. To...
Sahly, H, Kekow, J, Podschun, R, Schaff, M, Gross, W L, Ullmann, U
The production of antibodies to Klebsiella capsular polysaccharides was measured in sera from either HLA-B27-positive (HLA-B27+) or HLA-B27-negative (HLA-B27-) patients with classical ankylosing...
Transforming growth factor-beta and suppression of humoral immune responses in HIV infection.
Kekow, J, Wachsman, W, McCutchan, J A, Gross, W L, Zachariah, M, Carson, D A, ...
We reported previously that PBMC from HIV+ patients spontaneously release increased levels of TGF beta 1, contributing to defects in cellular immune responses. This study defines the implications of...
Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve.
Gross, W L, Bak, M I, Ingwall, J S, Arstall, M A, Smith, T W, Balligand, J L, ...
Cardiac myocytes express both constitutive and cytokine-inducible nitric oxide syntheses (NOS). NO and its congeners have been implicated in the regulation of cardiac contractile function. To...
Sahly, H, Kekow, J, Podschun, R, Schaff, M, Gross, W L, Ullmann, U
The production of antibodies to Klebsiella capsular polysaccharides was measured in sera from either HLA-B27-positive (HLA-B27+) or HLA-B27-negative (HLA-B27-) patients with classical ankylosing...
Transforming growth factor-beta and suppression of humoral immune responses in HIV infection.
Kekow, J, Wachsman, W, McCutchan, J A, Gross, W L, Zachariah, M, Carson, D A, ...
We reported previously that PBMC from HIV+ patients spontaneously release increased levels of TGF beta 1, contributing to defects in cellular immune responses. This study defines the implications of...
Csernok, E., Lüdemann, J., Gross, W. L., Bainton, D. F.
To investigate the distribution of proteinase 3, the target antigen of anti-cytoplasmic antibodies (ACPA or C-ANCA), within the organelles of resting normal human polymorphonuclear leukocytes and...
Braun, M. G., Csernok, E., Gross, W. L., Müller-Hermelink, H. K.
Proteinase 3 was identified as the target antigen of anticytoplasmic antibodies (ACPA/c-ANCA) in Wegener's granulomatosis (WG). Using the murine monoclonal antibody (MAb) WGM2, the authors localized...
Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo.
Csernok, E, Ernst, M, Schmitt, W, Bainton, D F, Gross, W L
Apart from the diagnostic value of anti-neutrophil cytoplasmic antibodies (ANCA), their detailed characterization and that of their corresponding antigens have opened new ways for the exploration of...
The plaque forming cell (PFC) and proliferative responses of human peripheral blood lymphocytes and highly purified blood B cells induced by pokeweed mitogen (PWM) and group A streptoccocal cell...
Gross, W L, Krüger, J, Gröschel-Stewart, U, Friedrich, H, Kunze, K
The HLA phenotype of fifty-four patients with myasthenia gravis (MG) was compared to that of 600 controls. When male and female patients were compared separately with the control group, HLA-B12 was...
Abnormal B cell response to T cell-independent polyclonal B cell activators in haemophilia A.
Kekow, J, Plendl, H, Gross, W L
In addition to T cell abnormalities, patients with haemophilia A show a separate B cell dysfunction. Characteristic are elevated spontaneous IgG (not IgM) levels in the patient's sera and in the...
Autoantibodies against cytoplasmic components of neutrophil granulocytes (ACPA) were detected in 18 of 32 patients with Wegener's granulomatosis (WG), but in none of the controls (n = 900), including...
Richter, C, Schnabel, A, Csernok, E, De Groot, K, Reinhold-Keller, E, Gross, W L
In this uncontrolled study 15 patients with ANCA-associated systemic vasculitis, who were poor responders to conventional therapy, were treated with single or multiple courses of intravenous...
ANCA and associated diseases: immunodiagnostic and pathogenetic aspects.
Gross, W L, Schmitt, W H, Csernok, E
The past decade has seen an explosion of data on the new group of autoantibodies known collectively as ANCA (anti-neutrophil cytoplasmic antibodies). ANCA are specific for granule proteins of...
Influence of TPA (12-O-tetradodecanoyl-phorbol-13-acetate) on human B lymphocyte function.
Falcioni, F, Rautmann, A, Berg, P A, Gross, W L
The effect of the tumour-promoting agent TPA (12-0-tetra-dodecanoyl-phorbol-13-acetate) on the proliferation and Ig secretion response of blood and tonsil lymphocytes was investigated and compared to...
SCHULTZ, H, SCHINKE, S, WEISS, J, Cerundolo, V, GROSS, W L, GADOLA, S
Although HLA class I expression is diminished in patients with defects in the transporter associated with antigen presentation (TAP), recurrent Gram-negative bacterial lung infections are found from...
Moosig, F, Csernok, E, Wang, G, Gross, W L
T cells are most likely to play an important role in the pathogenesis of WG, and recently a predominant Th1 pattern of immune response has been demonstrated in granulomatous inflammation. Since the...
Hellmich, B, Csernok, E, Trabandt, A, Gross, W L, Ernst, M
The theoretical risk of triggering vasculitis resulting from administration of G-CSF and GM-CSF to patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), such as...
Moosig, F, Csernok, E, Kumanovics, G, Gross, W L
Since proteinase 3 (PR3)-ANCA interact with PR3 on the surface of apoptotic polymorphonuclear neutrophils (PMN) and ingestion of apoptotic PMN is known to modulate macrophage inflammatory reactions,...
Peen, E, Malone, C, Myers, C, Williams, R C, Peck, A B, Csernok, E, ...
Amphipathic variable-region heavy chain 11-mer peptides from monoclonal human IgM antiproteinase-3 antibodies were studied for peripheral blood lymphocyte stimulation in 21 patients with Wegener's...
Increased Expression Of Ctla-4 (Cd152) By T And B Lymphocytes In Wegener'S Granulomatosis
Steiner, K, Moosig, F, Csernok, E, Selleng, K, Gross, W L, Fleischer, B, ...
CTLA-4 (CD152) is a surface molecule of activated T cells with sequence homology to CD28. Both molecules bind to the same ligands, B7.1 (CD80) and B7.2 (CD86) but have antagonistic functions. While...
LAMPRECHT, P, KUMANOVICS, G, MUELLER, A, CSERNOK, E, KOMOCSI, A, TRABANDT, A, ...
Wegener’s granulomatosis (WG) is characterized by a predominance of the type 1 T-helper cell (Th1) response. We have studied monocytic cytokine expression in untreated patients and in patients who...
STOFFEL, M P, CSERNOK, E, HERZBERG, C, JOHNSTON, T, CARROLL, S F, GROSS, W L
It was our purpose to determine the immunodiagnostic value of ANCA directed against BPI in diseases known to be associated with ANCA, such as ANCA-associated vasculitides, inflammatory bowel disease...
CSERNOK, E, SZYMKOWIAK, C H, MISTRY, N, DAHA, M R, GROSS, W L, KEKOW, J
TGF-β is a multifunctional cytokine modulating the onset and course of autoimmune diseases as shown in experimental models. The aim of this study was to investigate TGF-β expression in...
Bronchoalveolar lavage cell profile in methotrexate induced pneumonitis
Schnabel, A., Richter, C., Bauerfeind, S., Gross, W. L.
BACKGROUND: Pneumonitis is a rare but potentially life threatening side effect of methotrexate treatment for rheumatoid arthritis which needs to be distinguished from interstitial lung disease due to...
Hunzelmann, N., Genth, E., Krieg, T., Lehmacher, W., Melchers, I., Meurer, M., ...
Objective. Systemic sclerosis (SSc) is a rare, heterogeneous disease, which affects different organs and therefore requires interdisciplinary diagnostic and therapeutic management. To improve the...
Lack of association of mannose binding lectin variant alleles with systemic lupus erythematosus
Momot, T, Ahmadi‐Simab, K, Gause, A, Gross, W L, Gromnica‐Ihle, E, Peter, H H, ...
Voswinkel, J, Assmann, G, Held, G, Pitann, S, Gross, W L, Holl-Ulrich, K, ...
Increased amounts of anti-neutrophil cytoplasm antibody (ANCA) directed against proteinase 3 (PR3) are a diagnostic and pathogenic hallmark of full-blown Wegener's granulomatosis (WG). Aggregates of...