Structural Organization of Trypanosoma Cruzi (2009)
Since the initial description of Trypanosoma cruzi by Carlos Chagas in 1909, several research groups have used different microscopic techniques to obtain detailed information about the various...
Toxoplasma gondii : further studies on the subpellicular network (2009)
Lemgruber, Leandro, Kloetzel, John A, De Souza, Wanderley, Vommaro, Rossiane C
The association of the pellicle with cytoskeletal elements in Toxoplasma gondii allows this parasite to maintain its mechanical integrity and makes possible its gliding motility and cell invasion....
Brazilian contribution for a better knowledge on the biology of Toxoplasmagondii (2009)
De Souza, Wanderley, DaMatta, Renato A., Attias, Márcia
Historically, scientists in Brazil has significantly contributed to the biology, cultivation and structural organization of the pathogenic protozoan Toxoplasmagondii and its interaction with host...
Cavalcanti, Danielle, Shimada, Márcia, Probst, Christian, Souto-Padrón, Thais, De Souza, Wanderley, Goldenberg, Samuel, ...
Abstract Background The kinetoplast DNA (kDNA) of trypanosomatids consists of an unusual arrangement of circular molecules catenated into a single network. The diameter of the isolated kDNA network...
Ishida, Kelly, Rodrigues, Juliany, Ribeiro, Marcos, Vila, Taíssa, De Souza, Wanderley, Urbina, Julio A, ...
Abstract Background Although Candida species are commensal microorganisms, they can cause many invasive fungal infections. In addition, antifungal resistance can contribute to failure of treatment....
Tanaka, Marcelo N, Diaz, Bruno L, De Souza, Wanderley, Morgado-Diaz, Jose A
Abstract Background The apical junctional complex (AJC) is a dynamic structure responsible to maintain epithelial cell-cell adhesions and it plays important functions such as, polarity, mechanical...
Electron microscopy of trypanosomes - A historical view (2008)
Since the discovery of the electron microscope and the development of the initial techniques for the processing of biological samples for electron microscopy, the protozoan Trypanosoma cruzi has...
Martins-Duarte, Érica S., Urbina, Julio A., De Souza, Wanderley, Vommaro, Rossiane C.
Objectives: To study the antiproliferative effects of ER119884 and E5700, two quinuclidine-based inhibitors of squalene synthase (SQS), against Toxoplasma gondii tachyzoites in epithelial cells....
Martins-Duarte, Érica S., Urbina, Julio A., De Souza, Wanderley, Vommaro, Rossiane C.
Objectives: To study the antiproliferative effects of ER119884 and E5700, two quinuclidine-based inhibitors of squalene synthase (SQS), against Toxoplasma gondii tachyzoites in epithelial cells....
Programmed cell death in Trypanosoma cruzi induced by Bothrops jararaca venom (2005)
Deolindo, Poliana, Teixeira-Ferreira, André S., Melo, Edésio J.T., Arnholdt, Andrea Cristina Veto, De Souza, Wanderley, Alves, Elias W., ...
Cells die through a programmed process or accidental death, know as apoptosis or necrosis, respectively. Bothrops jararaca is a snake whose venom inhibits the growth of Trypanosoma cruzi epimastigote...
Abstract Members of the Trypanosomatidae family comprise a large number of species that are causative agents of important diseases such as sleeping sickness, Chagas' disease and Leishmaniasis. These...
Rodrigues, Marcio L., Travassos, Luiz R., Miranda, Kildare R., Franzen, Anderson J., Rozental, Sonia, De Souza, Wanderley, ...
A major ceramide monohexoside (CMH) was purified from lipidic extracts of Cryptococcus neoformans. This molecule was analyzed by high-performance thin-layer chromatography (HPTLC), gas chromatography...
Members of the Trypanosomatidae family comprise a large number of species that are causative agents of important diseases such as sleeping sickness, Chagas' disease and Leishmaniasis. These organisms...
Lu, Hong-Gang, Zhong, Li, De Souza, Wanderley, Benchimol, Marlene, Moreno, Silvia, Docampo, Roberto
The survival of a eukaryotic protozoan as an obligate parasite in the interior of a eukaryotic host cell implies its adaptation to an environment with a very different ionic composition from that of...
Chromosome Localization Changes in the Trypanosoma cruzi Nucleus
Faria, Marcella, Mortara, Renato A., Motta, Maria Cristina M., De Souza, Wanderley, Thiry, Marc, ...
Chromosome localization in the interphase nuclei of eukaryotes depends on gene replication and transcription. Little is known about chromosome localization in protozoan parasites such as...
Rozenfeld, Claudia, Martinez, Rodrigo, Figueiredo, Rodrigo T., Bozza, Marcelo T., Lima, Flávia R. S., Pires, Ana Lúcia, ...
The maintenance of a benign chronic Toxoplasma gondii infection is mainly dependent on the persistent presence of gamma interferon (IFN-γ) in the central nervous system (CNS). However,...
Peña-Diaz, Javier, Montalvetti, Andrea, Flores, Carmen-Lisset, Constán, Aurora, Hurtado-Guerrero, Ramon, De Souza, Wanderley, ...
3-Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is a key enzyme in the sterol biosynthesis pathway, but its subcellular distribution in the Trypanosomatidae family is somewhat controversial....
Novel Azasterols as Potential Agents for Treatment of Leishmaniasis and Trypanosomiasis
Lorente, Silvia Orenes, Rodrigues, Juliany C. F., Jiménez, Carmen Jiménez, Joyce-Menekse, Miranda, Rodrigues, Carlos, Croft, Simon L., ...
This paper describes the design and evaluation of novel azasterols as potential compounds for the treatment of leishmaniasis and other diseases caused by trypanosomatid parasites. Azasterols are a...
Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium
Tiuman, Tatiana Shioji, Ueda-Nakamura, Tânia, Garcia Cortez, Diógenes Aparício, Dias Filho, Benedito Prado, Morgado-Díaz, José Andrés, De Souza, Wanderley, ...
The in vitro activity of parthenolide against Leishmania amazonensis was investigated. Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract of aerial parts of Tanacetum...
Cryptic Paraflagellar Rod in Endosymbiont-Containing Kinetoplastid Protozoa
Gadelha, Catarina, Wickstead, Bill, De Souza, Wanderley, Gull, Keith
Cilia and flagella are central to many biological processes in a diverse range of organisms. The kinetoplastid protozoa are very appealing models for the study of flagellar function, particularly in...
Role for a P-type H+-ATPase in the acidification of the endocytic pathway of Trypanosoma cruzi
Vieira, Mauricio, Rohloff, Peter, Luo, Shuhong, De Souza, Wanderley, Docampo, Roberto
Previous studies in Trypanosoma cruzi, the etiologic agent of Chagas disease, have resulted in the cloning and sequencing of a pair of tandemly linked genes (TcHA1 and TcHA2) that encode P...
Rodrigues, Marcio L., Travassos, Luiz R., Miranda, Kildare R., Franzen, Anderson J., Rozental, Sonia, De Souza, Wanderley, ...
A major ceramide monohexoside (CMH) was purified from lipidic extracts of Cryptococcus neoformans. This molecule was analyzed by high-performance thin-layer chromatography (HPTLC), gas chromatography...
Members of the Trypanosomatidae family comprise a large number of species that are causative agents of important diseases such as sleeping sickness, Chagas' disease and Leishmaniasis. These organisms...
Lu, Hong-Gang, Zhong, Li, De Souza, Wanderley, Benchimol, Marlene, Moreno, Silvia, Docampo, Roberto
The survival of a eukaryotic protozoan as an obligate parasite in the interior of a eukaryotic host cell implies its adaptation to an environment with a very different ionic composition from that of...
Chromosome Localization Changes in the Trypanosoma cruzi Nucleus
Faria, Marcella, Mortara, Renato A., Motta, Maria Cristina M., De Souza, Wanderley, Thiry, Marc, ...
Chromosome localization in the interphase nuclei of eukaryotes depends on gene replication and transcription. Little is known about chromosome localization in protozoan parasites such as...
Rozenfeld, Claudia, Martinez, Rodrigo, Figueiredo, Rodrigo T., Bozza, Marcelo T., Lima, Flávia R. S., Pires, Ana Lúcia, ...
The maintenance of a benign chronic Toxoplasma gondii infection is mainly dependent on the persistent presence of gamma interferon (IFN-γ) in the central nervous system (CNS). However,...
Peña-Diaz, Javier, Montalvetti, Andrea, Flores, Carmen-Lisset, Constán, Aurora, Hurtado-Guerrero, Ramon, De Souza, Wanderley, ...
3-Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is a key enzyme in the sterol biosynthesis pathway, but its subcellular distribution in the Trypanosomatidae family is somewhat controversial....
Novel Azasterols as Potential Agents for Treatment of Leishmaniasis and Trypanosomiasis
Lorente, Silvia Orenes, Rodrigues, Juliany C. F., Jiménez, Carmen Jiménez, Joyce-Menekse, Miranda, Rodrigues, Carlos, Croft, Simon L., ...
This paper describes the design and evaluation of novel azasterols as potential compounds for the treatment of leishmaniasis and other diseases caused by trypanosomatid parasites. Azasterols are a...
Antileishmanial Activity of Parthenolide, a Sesquiterpene Lactone Isolated from Tanacetum parthenium
Tiuman, Tatiana Shioji, Ueda-Nakamura, Tânia, Garcia Cortez, Diógenes Aparício, Dias Filho, Benedito Prado, Morgado-Díaz, José Andrés, De Souza, Wanderley, ...
The in vitro activity of parthenolide against Leishmania amazonensis was investigated. Parthenolide is a sesquiterpene lactone purified from the hydroalcoholic extract of aerial parts of Tanacetum...
Cryptic Paraflagellar Rod in Endosymbiont-Containing Kinetoplastid Protozoa
Gadelha, Catarina, Wickstead, Bill, De Souza, Wanderley, Gull, Keith
Cilia and flagella are central to many biological processes in a diverse range of organisms. The kinetoplastid protozoa are very appealing models for the study of flagellar function, particularly in...
Role for a P-type H+-ATPase in the acidification of the endocytic pathway of Trypanosoma cruzi
Vieira, Mauricio, Rohloff, Peter, Luo, Shuhong, De Souza, Wanderley, Docampo, Roberto
Previous studies in Trypanosoma cruzi, the etiologic agent of Chagas disease, have resulted in the cloning and sequencing of a pair of tandemly linked genes (TcHA1 and TcHA2) that encode P...
Rozenfeld, Claudia, Martinez, Rodrigo, Seabra, Sérgio, Sant’Anna, Celso, Gonçalves, J. Gabriel R., Bozza, Marcelo, ...
Interferon (IFN)-γ, the main cytokine responsible for immunological defense against Toxoplasma gondii, is essential in all infected tissues, including the central nervous system. However,...
Diniz, José Antonio Picanço, Dos Santos, Zaire Alves, Braga, Marcio Augusto Galvão, Dias, Ádila Liliane Barros, De Almeida Medeiros, Daniele Barbosa, ...
In previous reports we proposed a new genus for Rhabdoviridae and described neurotropic preference and gross neuropathology in newborn albino Swiss mice after Curionopolis and Itacaiunas infections....
Fernandes Rodrigues, Juliany Cola, Concepcion, Juan Luis, Rodrigues, Carlos, Caldera, Aura, Urbina, Julio A., De Souza, Wanderley
ER-119884 and E5700, novel arylquinuclidine derivatives developed as cholesterol-lowering agents, were potent in vitro growth inhibitors of both proliferative stages of Leishmania amazonensis, the...
Ishida, Kelly, Rodrigues, Juliany Cola Fernandes, Ribeiro, Marcos Dornelas, Vila, Taíssa Vieira Machado, De Souza, Wanderley, Urbina, Julio A, ...
Cavalcanti, Danielle Pereira, Shimada, Márcia Kiyoe, Probst, Christian Macagnan, De Souza, Wanderley, Goldenberg, Samuel, ...
Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
De Souza, Wanderley, Rodrigues, Juliany Cola Fernandes
Sterols are constituents of the cellular membranes that are essential for their normal structure and function. In mammalian cells, cholesterol is the main sterol found in the various membranes....
Schoijet, Alejandra C., Miranda, Kildare, Girard-Dias, Wendell, De Souza, Wanderley, Flawiá, Mirtha M., Torres, Héctor N., ...
Trypanosoma cruzi, the etiological agent of Chagas disease, has the ability to respond to a variety of environmental changes during its life cycle both in the insect vector and in the vertebrate...