JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma (2009)
Chang, Qingshan, Chen, Jianguo, Beezhold, Kevin J, Castranova, Vince, Shi, Xianglin, Chen, Fei
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with an extremely poor prognosis. The classification of HCC based on the molecular signature is not...
Zhao, Jinshun, Bowman, Linda, Zhang, Xingdong, Shi, Xianglin, Jiang, Binghua, Castranova, Vincent, ...
Abstract Background Carcinogenicity of nickel compounds has been well documented. However, the carcinogenic effect of metallic nickel is still unclear. The present study investigates metallic nickel...
Apopa, Patrick L, Qian, Yong, Shao, Rong, Guo, Nancy, Schwegler-Berry, Diane, Pacurari, Maricica, ...
Abstract Background Engineered iron nanoparticles are being explored for the development of biomedical applications and many other industry purposes. However, to date little is known concerning the...
Fan, Guangqin, Feng, Chang, Li, Yu, Wang, Chunhong, Yan, Ji, Li, Wei, ...
Background: We carried out animal experiments based on the orthogonal design L8(27) setting seven factors with two different levels of each and 10 groups of rats. The nutrients tested were tyrosine,...
Imaging, Diagnosis, Prognosis Predicting Cancer Drug Response by Proteomic Profiling (2008)
Yan Ma, Zhenyu Ding, Yong Qian, Xianglin Shi, Vince Castranova, E. James Harner, ...
Abstract Purpose: Accurate prediction of an individual patient’s drug response is an important prerequisite of personalized medicine. Recent pharmacogenomics research in chemosensitivity prediction...
5. Differential Expression of the Identified Marker Genes between Cancer and (2008)
Lan Guo, Yan Ma, Rebecca Ward, Vince Castranova, Xianglin Shi, Yong Qian
WANG, CHUNHONG, LIANG, JIANCHENG, ZHANG, CHUNLIAN, BI, YONGYI, SHI, XIANGLIN, SHI, QUN
Objective: To investigate the effect of ascorbic acid [vitamin C (VC)] on liver damage parameters in the lead-exposed mice, when given in combination with thiamine [vitamin B1 (VB1)] at different...
Apigenin inhibits tumor angiogenesis through decreasing HIF-1{alpha} and VEGF expression (2007)
Fang, Jing, Zhou, Qiong, Liu, Ling-Zhi, Xia, Chang, Hu, Xiaowen, Shi, Xianglin, ...
Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF)...
Zhou, Qiong, Liu, Ling-Zhi, Fu, Beibei, Hu, Xiaowen, Shi, Xianglin, Fang, Jing, ...
Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) are important regulators of angiogenesis. HIF-1 is composed of HIF-1α and HIF-1β subunits, and regulates VEGF...
Nucleolin links to arsenic-induced stabilization of GADD45{alpha} mRNA (2006)
Zhang, Yadong, Bhatia, Deepak, Xia, Hongfeng, Castranova, Vince, Shi, Xianglin, Chen, Fei
The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial...
Zhou, Qiong, Liu, Ling-Zhi, Fu, Beibei, Hu, Xiaowen, Shi, Xianglin, Fang, Jing, ...
Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) are important regulators of angiogenesis. HIF-1 is composed of HIF-1α and HIF-1β subunits, and regulates VEGF...
Apigenin inhibits tumor angiogenesis through decreasing HIF-1{alpha} and VEGF expression (2006)
Fang, Jing, Zhou, Qiong, Liu, Ling-Zhi, Xia, Chang, Hu, Xiaowen, Shi, Xianglin, ...
Apigenin is a nontoxic dietary flavonoid with anti-tumor properties. We recently showed that apigenin inhibited hypoxia-inducible factor 1 (HIF-1) and VEGF expression in human ovarian cancer cells...
Nucleolin links to arsenic-induced stabilization of GADD45a mRNA (2005)
Yadong Zhang, Deepak Bhatia, Hongfeng Xia, Vince Castranova, Xianglin Shi, Fei Chen
The present study shows that arsenic induces GADD45a (growth arrest and DNA damage inducible gene 45a) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial cell...
Zhang, Siyuan, Lin, Zhong-Ning, Yang, Cheng-Feng, Shi, Xianglin, Ong, Choon-Nam, Shen, Han-Ming
Parthenolide (PN) is the main sesquiterpene lactone found in fever few with potent anti-inflammatory function. The anti-cancer property of PN has been demonstrated in both in vitro cell culture and...
Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms (2004)
Won, Yen-Kim, Ong, Choon-Nam, Shi, Xianglin, Shen, Han-Ming
Parthenolide (PN) is a major sesquiterpene lactone of feverfew (Tanacetum parthanium) with known anti-inflammatory activity. However, the anticancer effects of PN have not been well studied. In the...
Zhang, Siyuan, Lin, Zhong-Ning, Yang, Cheng-Feng, Shi, Xianglin, Ong, Choon-Nam, Shen, Han-Ming
Parthenolide (PN) is the main sesquiterpene lactone found in feverfew with potent anti-inflammatory function. The anticancer property of PN has been demonstrated in both in vitro cell culture and in...
Taylor, Michael D., Roberts, Jenny R., Leonard, Stephen S., Shi, Xianglin, Antonini, James M.
The goals of this study were to examine acute lung damage and inflammation, as well as free radical production, caused by welding fumes of different chemical composition and solubility. Fumes were...
Taylor, Michael D., Roberts, Jenny R., Leonard, Stephen S., Shi, Xianglin, Antonini, James M.
The goals of this study were to examine acute lung damage and inflammation, as well as free radical production, caused by welding fumes of different chemical compositions and solubilities. The fumes...
Taylor, Michael D., Roberts, Jenny R., Leonard, Stephen S., Shi, Xianglin, Antonini, James M.
The goals of this study were to examine acute lung damage and inflammation, as well as free radical production, caused by welding fumes of different chemical composition and solubility. Fumes were...
Effect of Cr(VI) Exposure on Sperm Quality: Human and Animal Studies (2001)
Li, Hong, Chen, Qiongyu, Li, Shien, Yao, Wu, Li, Linghong, Shi, Xianglin, ...
The semen status of male workers occupationally exposed to hexavalent chromium(VI) was investigated. Sperm counts from exposed workers were 47.05±2.13×106/ml and those from control group...
Mechanisms of Cr(VI)-induced p53 activation: the role of phosphorylation, mdm2 and ERK (2001)
The present study investigated the molecular mechanisms of p53 activation induced by Cr(VI), using human lung epithelial A549 cells. Cr(VI) increased both protein level and transactivation ability of...
Liang, Rongti, Senturker, Sema, Shi, Xianglin, Bal, Wojciech, Dizdarogluand, Miral, Kasprzak, Kazimierz S.
Epidemiological evidence suggests that certain paternal exposures to metals may increase the risk of cancer in the progeny. This effect may be associated with promutagenic damage to the sperm DNA....
Vanadate-induced activation of activator protein-1: role of reactive oxygen species (1999)
Ding, Min, Li, Jian-Jian, Leonard, Stephen S., Ye, Jian-Ping, Shi, Xianglin, Colburn, Nancy H., ...
The present study was undertaken to test the hypothesis that the toxicity and carcinogenicity of vanadium might arise from elevation of reactive oxygen species leading to activation of the...
Ye, Jianping, Zhang, Xiaoying, Young, Howard A., Mao, Yan, Shi, Xianglin
Incubation of chronuum(VI) [Cr(VI)] with cultured Jurkat cells resulted in activation of DNA binding activity of the nuclear factor (NF)-кB. In a combination with glutathione reductase, a Cr(VI)...
Shi, Xianglin, Mao, Yan, Knapton, Alan D., Ding, Min, Rojanasakul, Yongyut, Gannett, Peter M., ...
Incubation of Cr(VI) with ascorbate generated Cr(V), Cr(IV) and ascorbate-derived carbon-centered alkyl radicals, as well as formyl radicals. H2O2 caused generation of hydroxyl radicals (·OH) and...
Datta, Arun K., Shi, Xianglin, Kasprzak, Kazimierz S.
The oxidation of 2'-deoxyguanosine (dG) to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) in free dG and the dG residues of DNA and nucleohistone with H2O2 in the presence of Ni(II) and histidyl...
PKC Phosphorylation Increases the Ability of AFAP-110 to Cross-link Actin Filaments
Qian, Yong, Baisden, Joseph M., Cherezova, Lidia, Summy, Justin M., Guappone-Koay, Anne, Shi, Xianglin, ...
The actin filament-associated protein and Src-binding partner, AFAP-110, is an adaptor protein that links signaling molecules to actin filaments. AFAP-110 binds actin filaments directly and...
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway
Chen, Fei, Zhang, Zhuo, Bower, Jacquelyn, Lu, Yongju, Leonard, Stephen S., Ding, Min, ...
Arsenite is a known human carcinogen that induces tumorigenesis through either a genotoxic or an epigenetic mechanism. In this study, the effect of arsenite on cell cycle regulation and the...
Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.
The nuclear factor kappa B (NF-kappaB) family of transcription factors controls expression of a number of early response genes associated with inflammatory responses, cell growth, cell cycle...
Nucleolin links to arsenic-induced stabilization of GADD45α mRNA
Zhang, Yadong, Bhatia, Deepak, Xia, Hongfeng, Castranova, Vince, Shi, Xianglin, Chen, Fei
The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial...
Lin, Lin, Stringfield, Teresa M., Shi, Xianglin, Chen, Yan
RTP801 is a newly discovered stress-response gene that is induced by hypoxia and other cell stress signals. Arsenic is a heavy metal that is linked to carcinogenesis in humans. Here, we investigated...
PKC Phosphorylation Increases the Ability of AFAP-110 to Cross-link Actin Filaments
Qian, Yong, Baisden, Joseph M., Cherezova, Lidia, Summy, Justin M., Guappone-Koay, Anne, Shi, Xianglin, ...
The actin filament-associated protein and Src-binding partner, AFAP-110, is an adaptor protein that links signaling molecules to actin filaments. AFAP-110 binds actin filaments directly and...
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin–proteasome pathway
Chen, Fei, Zhang, Zhuo, Bower, Jacquelyn, Lu, Yongju, Leonard, Stephen S., Ding, Min, ...
Arsenite is a known human carcinogen that induces tumorigenesis through either a genotoxic or an epigenetic mechanism. In this study, the effect of arsenite on cell cycle regulation and the...
Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.
The nuclear factor kappa B (NF-kappaB) family of transcription factors controls expression of a number of early response genes associated with inflammatory responses, cell growth, cell cycle...
Lin, Lin, Stringfield, Teresa M., Shi, Xianglin, Chen, Yan
RTP801 is a newly discovered stress-response gene that is induced by hypoxia and other cell stress signals. Arsenic is a heavy metal that is linked to carcinogenesis in humans. Here, we investigated...
Nucleolin links to arsenic-induced stabilization of GADD45α mRNA
Zhang, Yadong, Bhatia, Deepak, Xia, Hongfeng, Castranova, Vince, Shi, Xianglin, Chen, Fei
The present study shows that arsenic induces GADD45α (growth arrest and DNA damage inducible gene 45α) mainly through post-transcriptional mechanism. Treatment of the human bronchial epithelial...
Nitric Oxide Inhibits HIV Tat-Induced NF-κB Activation
Chen, Fei, Lu, Yongju, Castranova, Vince, Rojanasakul, Yon, Miyahara, Kaoru, Shizuta, Yutaka, ...
To evaluate the roles of nitric oxide (NO) on human immunodeficiency virus (HIV) Tat-induced transactivation of HIV long terminal repeat (HIV-LTR), we examined the effect of NO in the regulation of...
New Insights into the Role of Nuclear Factor-κB in Cell Growth Regulation
Chen, Fei, Castranova, Vince, Shi, Xianglin
The nuclear factor (NF)-κB family of eukaryotic transcription factors plays an important role in the regulation of immune response, embryo and cell lineage development, cell apoptosis, cell-cycle...
Gao, Ning, Rahmani, Mohamed, Shi, Xianglin, Dent, Paul, Grant, Steven
Interactions between the endogenous estradiol metabolite 2-medroxyestradiol (2-ME) and histone deacetylase inhibitors (HDACIs) have been investigated in human leukemia cells. Coadministration of...
Cellular Pyrin Domain-Only Protein 2 Is a Candidate Regulator of Inflammasome Activation▿
Dorfleutner, Andrea, Bryan, Nicole B., Talbott, Siera J., Funya, Kristin N., Rellick, Stephanie L., Reed, John C., ...
Pyrin domain (PYD) proteins have recently emerged as important signaling molecules involved in the development of innate immunity against intracellular pathogens through activation of inflammatory...
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells
Li, Jingxia, Chen, Haobin, Tang, Moon-Shong, Shi, Xianglin, Amin, Shantu, Desai, Dhimant, ...
5-Methylchrysene has been found to be a complete carcinogen in laboratory animals. However, the tumor promotion effects of (±)-anti-5-methylchrysene-1,2-diol-3,4-epoxide (5-MCDE) remain unclear. In...
Apopa, Patrick L, Qian, Yong, Shao, Rong, Guo, Nancy Lan, Schwegler-Berry, Diane, Pacurari, Maricica, ...
Ma, Cuiling, Bower, Kimberly A., Chen, Gang, Shi, Xianglin, Ke, Zun-Ji, Luo, Jia
The Ewing's sarcoma family of tumors (ESFT) includes Ewing's sarcoma (ES), Askin's tumor of the chest wall, and peripheral primitive neuroectodermal tumor. Basic fibroblast growth factor (FGF2)...