Laederach, Alain, Cradic, Kendall W., Brazin, Kristine N., Zamoon, Jamillah, Fulton, D. Bruce, Huang, Xin-Yun, ...
A nuclear magnetic resonance (NMR) investigation of a fragment of the nonreceptor Tec family tyrosine kinase Btk has revealed an intricate set of coupled monomer-dimer equilibria. The Btk fragment...
Identification of the binding site for Gqα on its effector Bruton’s tyrosine kinase
Heterotrimeric G proteins and tyrosine kinases are two major cellular signal transducers. Although G proteins are known to activate tyrosine kinases, the activation mechanism is not clear. Here, we...
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice
Shan, Dandan, Chen, Lin, Njardarson, Jon T., Gaul, Christoph, Ma, Xiaojing, Danishefsky, Samuel J., ...
Tumor metastasis is the most common cause of death in cancer patients. Here, we show that two, fully synthetic migrastatin analogues, core macroketone and core macrolactam, are potent inhibitors of...
Binding of Src to Na+/K+-ATPase Forms a Functional Signaling Complex
Tian, Jiang, Cai, Ting, Yuan, Zhaokan, Wang, Haojie, Liu, Lijun, Haas, Michael, ...
We have shown that ouabain activates Src, resulting in subsequent tyrosine phosphorylation of multiple effectors. Here, we tested if the Na+/K+-ATPase and Src can form a functional signaling complex....
Identification of the binding site for Gqα on its effector Bruton’s tyrosine kinase
Heterotrimeric G proteins and tyrosine kinases are two major cellular signal transducers. Although G proteins are known to activate tyrosine kinases, the activation mechanism is not clear. Here, we...
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice
Shan, Dandan, Chen, Lin, Njardarson, Jon T., Gaul, Christoph, Ma, Xiaojing, Danishefsky, Samuel J., ...
Tumor metastasis is the most common cause of death in cancer patients. Here, we show that two, fully synthetic migrastatin analogues, core macroketone and core macrolactam, are potent inhibitors of...
Binding of Src to Na+/K+-ATPase Forms a Functional Signaling Complex
Tian, Jiang, Cai, Ting, Yuan, Zhaokan, Wang, Haojie, Liu, Lijun, Haas, Michael, ...
We have shown that ouabain activates Src, resulting in subsequent tyrosine phosphorylation of multiple effectors. Here, we tested if the Na+/K+-ATPase and Src can form a functional signaling complex....
Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR
Sun, Yutong, Huang, Jianyun, Xiang, Yang, Bastepe, Murat, Jüppner, Harald, Kobilka, Brian K, ...
G-protein-coupled receptors (GPCRs) mostly signal through heterotrimeric G proteins. Increasing evidence suggests that GPCRs could function in a G-protein-independent manner. Here, we show that at...
Specific Antibodies to the External Vestibule of Voltage-gated Potassium Channels Block Current
Zhou, Ben-Yuan, Ma, Wei, Huang, Xin-Yun
Using delayed-rectifier potassium channels as examples, we have designed two specific blockers by generating specific antipeptide antibodies to epitopes in the external vestibules of two channel...
Laederach, Alain, Cradic, Kendall W., Brazin, Kristine N., Zamoon, Jamillah, Fulton, D. Bruce, Huang, Xin-Yun, ...
A nuclear magnetic resonance (NMR) investigation of a fragment of the nonreceptor Tec family tyrosine kinase Btk has revealed an intricate set of coupled monomer-dimer equilibria. The Btk fragment...
Liu, Wencheng, Vives-Bauza, Cristofol, Yamamoto, Ai, Tan, Yingcai, Li, Yanping, ...
Mutations in PTEN induced kinase 1 (PINK1), a mitochondrial Ser/Thr kinase, cause an autosomal recessive form of Parkinson's disease (PD), PARK6. Here, we report that PINK1 exists as a dimer in...
cAMP Inhibits Cell Migration by Interfering with Rac-induced Lamellipodium Formation*
Chen, Lin, Zhang, J. Jillian, Huang, Xin-Yun
Cell migration is critical for animal development and physiological as well as pathological responses. One important step during cell migration is the formation of lamellipodia at the leading edge of...