Yi-Heng Hao

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations (2006)

Tu, Huiping ; JFA; CORA, Nelson, Omar, Bezprozvanny, Arseny, Wang, Zhengnan, Lee, Sheu-Fen, Hao, Yi-Heng, ...

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder. Mutations in presenilins 1 and 2 (PS1 and PS2) account for approximately 40% of familial AD (FAD) cases. FAD...

Effect of Cholesterol on the Formation of an Interdigitated Gel Phase in Lysophosphatidylcholine and Phosphatidylcholine Binary Mixtures (2001)

Lu, Jing-Ze, Hao, Yi-Heng, Chen, Jian-Wen

We previously reported that 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) forms an interdigitated gel phase in the presence of l-palmitoyl-sn-glycero-3-phosphocholine (16: 0LPC) at...

Structural Requirements for Yersinia YopJ Inhibition of MAP Kinase Pathways

Hao, Yi-Heng, Wang, Yong, Burdette, Dara, Mukherjee, Sohini, Keitany, Gladys, Goldsmith, Elizabeth, ...

MAPK signaling cascades are evolutionally conserved. The bacterial effector, YopJ, uses the unique activity of Ser/Thr acetylation to inhibit the activation of the MAPK kinase (MKK) and prevent...