Yuan-Xiang Pan

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, Chin, Dudenhausen, Elizabeth, Chen, Hong, Pan, Yuan-Xiang, Gjymishka, Altin, Kilberg, Michael S.

For animals, dietary protein is critical for the nutrition of the organism and, at the cellular level, protein nutrition translates into amino acid availability. Amino acid deprivation triggers the...

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, Stela S., Thiaville, Michelle M., Pan, Yuan-Xiang, Zhong, Can, Kilberg, Michael S.

The neutral amino acid transport activity, System A, is enhanced by amino acid limitation of mammalian cells. Of the three gene products that encode System A activity, the one that exhibits this...

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, Chin, Dudenhausen, Elizabeth, Chen, Hong, Pan, Yuan-Xiang, Gjymishka, Altin, Kilberg, Michael S.

For animals, dietary protein is critical for the nutrition of the organism and, at the cellular level, protein nutrition translates into amino acid availability. Amino acid deprivation triggers the...

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, Stela S., Thiaville, Michelle M., Pan, Yuan-Xiang, Zhong, Can, Kilberg, Michael S.

The neutral amino acid transport activity, System A, is enhanced by amino acid limitation of mammalian cells. Of the three gene products that encode System A activity, the one that exhibits this...

Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation

Pan, Yuan-Xiang, Chen, Hong, Thiaville, Michelle M., Kilberg, Michael S.

Expression of ATF3 (activating transcription factor 3) is induced by a variety of environmental stress conditions, including nutrient limitation. In the present study, we demonstrate that the...

MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells*

Thiaville, Michelle M., Pan, Yuan-Xiang, Gjymishka, Altin, Zhong, Can, Kaufman, Randal J., Kilberg, Michael S.

The mammalian amino acid response (AAR) pathway is up-regulated by protein or amino acid depletion. This pathway involves detection of uncharged tRNA by the GCN2 kinase, phosphorylation of the...