Zhizhuang Joe Zhao

Crystal structure of human protein-tyrosine phosphatase SHP-1 (2002)

Yang, Jian, Liu, Lijun, He, Dandan, Song, Xi, Liang, Xiaoshan, Zhao, Zhizhuang Joe, ...

SHP-1 is a cytosolic protein-tyrosine phosphatase that behaves as a negative regulator in eukaryotic cellular signaling pathways. To understand its regulatory mechanism, we have determined the...

Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1 (2000)

Yang, Jian, Cheng, Zhiliang, Niu, Tian-Qi, Liang, Xiaoshan, Zhao, Zhizhuang Joe, Zhou, G. Wayne

The substrate specificity of the catalytic domain of SHP-1, an important regulator in the proliferation and development of hematopoietic cells, is critical for understanding the physiological...

Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1 (1998)

Yang, Jian, Liang, Xiaoshan, Niu, Tian-Qi, Meng, Wuyi, Zhao, Zhizhuang Joe, Zhou, G. Wayne

The crystal structures of the protein-tyrosine phosphatase SHP-1 catalytic domain and the complex it forms with the substrate analogue tungstate have been determined and refined to crystallographic R...

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells

Zhang, Ming-Zhi, Mai, Weiyi, Li, Cunxi, Cho, Sae-youll, Hao, Chuanming, Moeckel, Gilbert, ...

Mutations of the polycystic kidney and hepatic disease 1 (PKHD1) gene have been shown to cause autosomal recessive polycystic kidney disease (ARPKD), but the cellular functions of the gene product...

Identification of an Acquired JAK2 Mutation in Polycythemia Vera

Zhao, Runxiang, Xing, Shu, Li, Zhe, Fu, Xueqi, Li, Qingshan, Krantz, Sanford B., ...

Polycythemia vera (PV) is a human clonal hematological disorder. The molecular etiology of the disease has not been identified. PV hematopoietic progenitor cells exhibit hypersensitivity to growth...

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells

Zhang, Ming-Zhi, Mai, Weiyi, Li, Cunxi, Cho, Sae-youll, Hao, Chuanming, Moeckel, Gilbert, ...

Mutations of the polycystic kidney and hepatic disease 1 (PKHD1) gene have been shown to cause autosomal recessive polycystic kidney disease (ARPKD), but the cellular functions of the gene product...

JAK2V617F: prevalence in a large Chinese hospital population

Xu, Xuesong, Zhang, Qi, Luo, Jian, Xing, Shu, Li, Qingshan, Krantz, Sanford B., ...

Recently, the JAK2V617F mutation was found in patients with myeloproliferative disorders (MPDs), including most with polycythemia vera (PV). The mutant JAK2 has increased kinase activity, and it was...

Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function

Wang, Yingchun, Vachon, Eric, Zhang, Jinyi, Cherepanov, Vera, Kruger, Joshua, Li, Jun, ...

MEG2, a protein tyrosine phosphatase with a unique NH2-terminal lipid-binding domain, binds to and is modulated by the polyphosphoinositides PI(4,5)P2 and PI(3,4,5)P3. Recent data implicate MEG2 in...

Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice

Xing, Shu, Wanting, Tina Ho, Zhao, Wanming, Ma, Junfeng, Wang, Shaofeng, Xu, Xuesong, ...

The JAK2V617F mutation was found in most patients with myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. We have generated...